Acquired hypertrichosis lanuginosa

Summary

Acquired hypertrichosis lanuginosa (MONDO:0016380) is a disease. A subtype of hypertrichosis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: <1 / 1 000 000 (Worldwide) [Orphanet-validated]
• Phenotypes (HPO): 18

Clinical features

Epidemiology

Prevalence records

2 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Cases/families		60	Worldwide	Validated
Point prevalence	<1 / 1 000 000		Worldwide	Validated

Signs & symptoms

Clinical features (HPO)

18 HPO clinical features (Orphanet curated; top 18 by frequency):

HPO ID	Term	Frequency
HP:0000492	Abnormal eyelid morphology	Very frequent (80-99%)
HP:0000534	Abnormal eyebrow morphology	Very frequent (80-99%)
HP:0002213	Fine hair	Very frequent (80-99%)
HP:0002230	Generalized hirsutism	Very frequent (80-99%)
HP:0002664	Neoplasm	Very frequent (80-99%)
HP:0005599	Hypopigmentation of hair	Very frequent (80-99%)
HP:0000158	Macroglossia	Frequent (30-79%)
HP:0000206	Glossitis	Frequent (30-79%)
HP:0000956	Acanthosis nigricans	Occasional (5-29%)
HP:0001072	Thickened skin	Occasional (5-29%)
HP:0001824	Weight loss	Occasional (5-29%)
HP:0002028	Chronic diarrhea	Occasional (5-29%)
HP:0002716	Lymphadenopathy	Occasional (5-29%)
HP:0004396	Poor appetite	Occasional (5-29%)
HP:0008064	Ichthyosis	Occasional (5-29%)
HP:0100013	Neoplasm of the breast	Occasional (5-29%)
HP:0100606	Neoplasm of the respiratory system	Occasional (5-29%)
HP:0100615	Ovarian neoplasm	Occasional (5-29%)

Identifiers

Disease identifiers

Field	Value
Canonical name	acquired hypertrichosis lanuginosa
Mondo ID	MONDO:0016380
Orphanet	2221
ICD-10-CM	L68.1
ICD-11	1885858920
SNOMED CT	25967007
UMLS	C0343072
MedGen	87468
GARD	0002864
Is cancer (heuristic)	no

Also known as: hypertrichosis lanuginosa, acquired

Disease family

This is a subtype of hypertrichosis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › integumentary system disorder › disorder of pilosebaceous unit › hypertrichosis › acquired hypertrichosis lanuginosa

Related subtypes (10): hypertrichosis of eyelid, gingival fibromatosis-hypertrichosis syndrome, hypertrichosis cubiti-short stature syndrome, cataract-hypertrichosis-intellectual disability syndrome, cervical hypertrichosis-peripheral neuropathy syndrome, Rabson-Mendenhall syndrome, isolated anterior cervical hypertrichosis, hypertrichosis lanuginosa congenita, autosomal dominant preaxial polydactyly-upperback hypertrichosis syndrome, hypertrichosis-acromegaloid facial appearance syndrome

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.