ACTH-producing pituitary gland adenoma
disease diseaseOn this page
Also known as ACTH producing pituitary gland adenomaACTH secreting adenoma of pituitaryACTH secreting adenoma of the pituitaryACTH-producing pituitary adenomaACTH-secreting adenoma of pituitaryACTH-secreting adenoma of pituitary glandACTH-secreting adenoma of the pituitaryACTH-secreting adenoma of the pituitary glandACTHomaadrenocorticotropin producing adenoma of pituitaryadrenocorticotropin producing adenoma of pituitary glandadrenocorticotropin producing adenoma of the pituitaryadrenocorticotropin producing adenoma of the pituitary glandadrenocorticotropin producing pituitary adenomaadrenocorticotropin producing pituitary gland adenomaadrenocorticotropin secreting adenoma of pituitaryadrenocorticotropin secreting adenoma of pituitary glandadrenocorticotropin secreting adenoma of the pituitaryadrenocorticotropin secreting adenoma of the pituitary gland
Summary
ACTH-producing pituitary gland adenoma (MONDO:0006068) is a cancer and 3 clinical trials. Top therapeutic interventions include cabergoline. A subtype of pituitary gland adenoma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Clinical trials: 3
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | ACTH-producing pituitary gland adenoma |
| Mondo ID | MONDO:0006068 |
| EFO | EFO:1000066 |
| NCIT | C7462 |
| UMLS | C1306214 |
| MedGen | 266291 |
| GARD | 0024280 |
| Anatomy (UBERON) | UBERON:0000007 |
| Is cancer (heuristic) | yes |
Also known as: ACTH producing pituitary gland adenoma · ACTH secreting adenoma of pituitary · ACTH secreting adenoma of the pituitary · ACTH-producing pituitary adenoma · ACTH-producing pituitary gland adenoma · ACTH-secreting adenoma of pituitary · ACTH-secreting adenoma of pituitary gland · ACTH-secreting adenoma of the pituitary · ACTH-secreting adenoma of the pituitary gland · ACTHoma · adrenocorticotropin producing adenoma of pituitary · adrenocorticotropin producing adenoma of pituitary gland · adrenocorticotropin producing adenoma of the pituitary · adrenocorticotropin producing adenoma of the pituitary gland · adrenocorticotropin producing pituitary adenoma · adrenocorticotropin producing pituitary gland adenoma · adrenocorticotropin secreting adenoma of pituitary · adrenocorticotropin secreting adenoma of pituitary gland · adrenocorticotropin secreting adenoma of the pituitary · adrenocorticotropin secreting adenoma of the pituitary gland (+11 more)
Disease family
This is a subtype of pituitary gland adenoma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › epithelial neoplasm › adenoma › pituitary gland adenoma › ACTH-producing pituitary gland adenoma
Related subtypes (8): functioning pituitary gland adenoma, pituitary gland mixed eosinophil-basophil adenoma, growth hormone-producing pituitary gland adenoma, pituitary gland acidophil adenoma, pituitary gland basophil adenoma, chromophobe adenoma, familial isolated pituitary adenoma, non-functioning pituitary adenoma
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 3.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 2 |
| PHASE3 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00889525 | PHASE3 | COMPLETED | Study of Cabergoline in Treatment of Corticotroph Pituitary Tumor |
| NCT06701838 | Not specified | NOT_YET_RECRUITING | Osilodrostat Therapy and 11C-methionine PET to Improve Corticotroph Adenoma Detection |
| NCT04121988 | Not specified | TERMINATED | Diagnostic Yield of Deep Learning Based Denoising MRI in Cushing’s Disease |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| CABERGOLINE | 4 | 1 |
| CHEMBL4593105 | 0 | 1 |
| CHEMBL5192470 | 0 | 1 |
Related Atlas pages
- Drugs: Cabergoline