ACTH-producing pituitary gland neoplasm

Summary

ACTH-producing pituitary gland neoplasm (MONDO:0045058) is a cancer and 2 clinical trials. A subtype of pituitary tumor — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Clinical trials: 2

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	ACTH-producing pituitary gland neoplasm
Mondo ID	MONDO:0045058
NCIT	C7909
UMLS	C0278862
MedGen	82997
GARD	0025940
Anatomy (UBERON)	UBERON:0000007
Is cancer (heuristic)	yes

Also known as: ACTH producing pituitary gland neoplasm · ACTH-producing pituitary gland neoplasm · ACTH-producing pituitary neoplasm · ACTH-producing pituitary tumor · ACTH-producing pituitary tumour · ACTH-secreting tumor of pituitary · ACTH-secreting tumor of the pituitary · ACTH-secreting tumour of pituitary · ACTH-secreting tumour of the pituitary · adrenocorticotropin producing pituitary gland tumor · adrenocorticotropin producing pituitary gland tumour · adrenocorticotropin secreting neoplasm of pituitary · adrenocorticotropin secreting neoplasm of the pituitary · adrenocorticotropin secreting pituitary gland tumor · adrenocorticotropin secreting pituitary gland tumour · adrenocorticotropin secreting tumor of pituitary · adrenocorticotropin secreting tumor of the pituitary · adrenocorticotropin secreting tumour of pituitary · adrenocorticotropin secreting tumour of the pituitary · corticotropin secreting pituitary gland neoplasm (+3 more)

Disease family

This is a subtype of pituitary tumor. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › endocrine gland neoplasm › pituitary tumor › ACTH-producing pituitary gland neoplasm

Related subtypes (8): pituitary cancer, posterior pituitary gland neoplasm, prolactin producing pituitary tumor, non-functioning pituitary gland neoplasm, functioning pituitary gland neoplasm, pituitary gland adenoma, growth hormone-producing pituitary gland neoplasm, benign neoplasm of pituitary gland

Subtypes (2): ACTH-producing pituitary gland adenoma, ACTH-producing pituitary gland carcinoma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 2.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE2	1
Not specified	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT02749227	PHASE2	TERMINATED	Pasireotide LAR Therapy of Silent Corticotroph Pituitary Tumors
NCT07463625	Not specified	RECRUITING	Evaluation of Positron Emission Tomography (PET) With [18F]FET for the Detection of ACTH-Secreting Corticotroph Pituitary Neuroendocrine Tumors.