Active peptic ulcer disease

Summary

Active peptic ulcer disease (MONDO:0004242) is a disease and 2 clinical trials. Top therapeutic interventions include misoprostol and misoprostol acid. A subtype of peptic ulcer disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 2

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	active peptic ulcer disease
Mondo ID	MONDO:0004242
MeSH	D010438
DOID	DOID:749
SNOMED CT	64121000, 74474003
Is cancer (heuristic)	no

Disease family

This is a subtype of peptic ulcer disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › digestive system disorder › peptic ulcer disease › active peptic ulcer disease

Related subtypes (5): gastric ulcer, gastrojejunal ulcer, peptic ulcer perforation, duodenal ulcer, peptic esophagitis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 2.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE4	1
Not specified	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT03675672	PHASE4	RECRUITING	Prevention of Recurrent Ulcer Bleeding in Patients With Idiopathic Gastroduodenal Ulcer
NCT02020603	Not specified	COMPLETED	Efficacy of Hemostasis by Soft Coagulation Using Endoscopic Hemostatic Forceps for Acute Peptic Ulcer Bleeding

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
MISOPROSTOL	4	1
CHEMBL4064157	0	1
MISOPROSTOL ACID	-1	1