Active tuberculosis

Summary

Active tuberculosis (MONDO:0100481) is a disease and 12 clinical trials. A subtype of tuberculosis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 12

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	active tuberculosis
Mondo ID	MONDO:0100481
UMLS	C0151332
MedGen	508753
GARD	0026239
Is cancer (heuristic)	no

Also known as: active TB

Disease family

This is a subtype of tuberculosis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › bacterial infectious disease › primary bacterial infectious disease › tuberculosis › active tuberculosis

Related subtypes (11): extrapulmonary tuberculosis, pulmonary tuberculosis, endocrine tuberculosis, tuberculoma, latent tuberculosis infection, drug-resistant tuberculosis, tuberculous encephalopathy, primary tuberculous lymphadenitis, primary bone and joint tuberculosis, multifocal tuberculosis, primary tuberculosis of the digestive system

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 12.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	12

Top trials by phase / activity

NCT	Phase	Status	Title
NCT05045391	Not specified	ACTIVE_NOT_RECRUITING	Pulmonary Aspergillosis in Tuberculosis Patients
NCT06838780	Not specified	ACTIVE_NOT_RECRUITING	Host Response to Infection by Direct Analysis of Leukocyte Single Cell-type Gene Expression/transcript Abundance, Direct LS-TA
NCT06846645	Not specified	NOT_YET_RECRUITING	Host Response to Infection by Direct Analysis of Leukocyte Single Cell-type Gene Expression/transcript Abundance, Direct LS-TA. a Prospective Study Will Evaluate the Performance of Direct LS-TA in Triage Febrile Patients Into Major Categories of Infections: Viral, Bacterial or Active Tuberculosis.
NCT01269268	Not specified	COMPLETED	Characterization and Evaluation of Diagnostic Biomarkers for Tuberculosis
NCT02042261	Not specified	COMPLETED	The Role of Therapeutic Drug Monitoring in Tuberculosis - a Pilot Study
NCT02512484	Not specified	UNKNOWN	Improving the Detection of Active Tuberculosis in Accident and Emergency Departments
NCT02639936	Not specified	COMPLETED	New Generation IGRA in Immunocompromised Individuals
NCT02898623	Not specified	TERMINATED	Serological Test for the Diagnosis of TB
NCT03271567	Not specified	COMPLETED	Nanodisk-MS Assay for the Diagnosis of Active Pulmonary and Extrapulmonary Tuberculosis in Hospitalized Patients
NCT04048018	Not specified	COMPLETED	Performance Evaluation of the VIDAS TB-IGRA Assay.
NCT05048381	Not specified	WITHDRAWN	miRNA in Sweat, a Novel Digital Biomarker for Detection of Active Tuberculosis (TB)
NCT06408129	Not specified	COMPLETED	COMPArison of Screening Strategies for Active TuBerculosis (COMPASS-TB)