Acute apical periodontitis

Summary

Acute apical periodontitis (MONDO:0001338) is a disease and 5 clinical trials. A subtype of acute pericementitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 5

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	acute apical periodontitis
Mondo ID	MONDO:0001338
DOID	DOID:11693
ICD-10-CM	K04.4
SNOMED CT	718053009
UMLS	C4084770
MedGen	901807
Is cancer (heuristic)	no

Also known as: acute apical periodontitis of pulpal origin

Disease family

This is a subtype of acute pericementitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › periodontal disorder › periodontitis › acute pericementitis › acute apical periodontitis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 5.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	5

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06734559	Not specified	ACTIVE_NOT_RECRUITING	Assessment of Masseter Muscle With Ultrasonography
NCT07192289	Not specified	NOT_YET_RECRUITING	Using Platelet-rich Fibrin in Regenerative Endodontic Treatment in Mature Permanent Teeth
NCT03553641	Not specified	COMPLETED	The Effect of Central Sensitization on Assessment Capacity of Patients
NCT06653608	Not specified	COMPLETED	Clinical Efficacy of Novel Jasminum-based Calcium Hydroxide Medicament
NCT06853028	Not specified	COMPLETED	The Role of Root Canal Treatment in Alleviating Endodontic Pain-Induced Asymmetry and Restoring Muscle Balance