Acute asthma
disease diseaseOn this page
Summary
Acute asthma (MONDO:0850283) is a disease and 20 clinical trials. Top therapeutic interventions include albuterol, budesonide, and ipratropium bromide. A subtype of asthma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 20
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | acute asthma |
| Mondo ID | MONDO:0850283 |
| DOID | DOID:0080810 |
| UMLS | C0349790 |
| MedGen | 578946 |
| Is cancer (heuristic) | no |
Disease family
This is a subtype of asthma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › respiratory system disorder › lower respiratory tract disorder › bronchial disorder › asthma › acute asthma
Related subtypes (7): cough variant asthma, intrinsic asthma, status asthmaticus, allergic asthma, childhood onset asthma, occupational asthma, chronic asthma
Subtypes (1): near-fatal asthma
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 20.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| PHASE4 | 9 |
| Not specified | 7 |
| PHASE3 | 2 |
| PHASE2 | 1 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT07402707 | PHASE4 | RECRUITING | Dosing of Steroids for Acute Asthma Given in the Emergency Department - a Pilot Randomised Feasibility Trial of Dexamethasone in Children |
| NCT00393367 | PHASE4 | COMPLETED | Budesonide Inhalation Suspension for Acute Asthma in Children |
| NCT00733317 | PHASE4 | COMPLETED | Budesonide for Emergency Treatment of Acute Wheezing in Children |
| NCT00733473 | PHASE4 | COMPLETED | Nebulized Budesonide for Children Who Are Hospitalized for Acute Wheezing |
| NCT00819637 | PHASE4 | TERMINATED | A Pilot Study to Determine the Most Effective Dose of Arformoterol for Treating Acute Asthmatic Patients |
| NCT01304901 | PHASE4 | COMPLETED | Effect of Addition of Single Dose of Oral Montelukast to Standard Treatment in Acute Asthma in Preschool Children. |
| NCT01403467 | PHASE4 | COMPLETED | Impact of Continuous Positive Airway Pressure on the Treatment of Acute Asthma Exacerbation |
| NCT03369119 | PHASE4 | COMPLETED | Effect of Addition Oral Montelukast to Standard Treatment in Acute Asthma in Hospitalized Preschool Children |
| NCT03698630 | PHASE4 | COMPLETED | Single Dose Oral Dexamethasone Versus Multi-dose Prednisolone in the Treatment of Acute Exacerbations of Asthma in Children |
| NCT00990847 | PHASE3 | COMPLETED | Nebulized Procaterol Versus Nebule Salbutamol for the Treatment of Moderate Acute Asthma |
| NCT01868113 | PHASE3 | COMPLETED | Inhaled Corticosteroids in U-5 Children With Acute Respiratory Infection in Uganda: A Randomised Trial |
| NCT01429415 | PHASE2 | COMPLETED | Magnesium Nebulization Utilization in Management of Pediatric Asthma |
| NCT04016220 | PHASE1 | UNKNOWN | Nebulized Budesonide Combined With Systemic Corticosteroid in Acute Severe Asthma |
| NCT07582211 | Not specified | NOT_YET_RECRUITING | Bilevel Positive Airway Pressure (BPAP) for Severe Asthma |
| NCT00922350 | Not specified | COMPLETED | Heliox and Posture in Patients With Asthma |
| NCT01016444 | Not specified | COMPLETED | Acute Asthma Responsiveness and B2 Adrenergic Receptors Polymorphisms |
| NCT01079000 | Not specified | COMPLETED | Emergency Department (ED)-Directed Interventions to Improve Asthma Outcomes |
| NCT01196377 | Not specified | COMPLETED | Optimal Albuterol Regimens for Acute Asthma Exacerbations: DBRCT Pilot Study |
| NCT01695031 | Not specified | COMPLETED | Feasibility of an ED Initiated Online Asthma Management Program for Urban Teens |
| NCT06005337 | Not specified | COMPLETED | Supporting Parents to Choose Wisely |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| ALBUTEROL | 4 | 1 |
| BUDESONIDE | 4 | 1 |
| IPRATROPIUM BROMIDE | 4 | 1 |
| LEVOSALBUTAMOL | 4 | 1 |
| PREDNISOLONE | 4 | 1 |
| PREDNISOLONE SODIUM PHOSPHATE | 4 | 1 |
| PREDNISONE | 4 | 1 |
| SODIUM CHLORIDE | 4 | 1 |
| MAGNESIUM | 3 | 1 |
| PROCATEROL | 3 | 1 |
| CHEMBL1237108 | 0 | 1 |
| CHEMBL15720 | 0 | 1 |
| CHEMBL1908368 | 0 | 1 |
| CHEMBL249466 | 0 | 1 |