Acute bronchiolitis
diseaseOn this page
Also known as acute capillary bronchiolitisCapillary pneumonia
Summary
Acute bronchiolitis (MONDO:0020680) is a disease and 23 clinical trials. Top therapeutic interventions include montelukast, sodium chloride, and albuterol. A subtype of bronchiolitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 23
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | acute bronchiolitis |
| Mondo ID | MONDO:0020680 |
| ICD-10-CM | J21 |
| ICD-11 | 1310075986 |
| NCIT | C39659 |
| SNOMED CT | 5505005 |
| UMLS | C0001311 |
| MedGen | 113 |
| Is cancer (heuristic) | no |
Also known as: acute bronchiolitis · acute capillary bronchiolitis · Capillary pneumonia
Disease family
This is a subtype of bronchiolitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › respiratory system disorder › lower respiratory tract disorder › lung disorder › bronchiolitis › acute bronchiolitis
Related subtypes (5): bronchiolitis obliterans syndrome, toxic bronchiolitis, respiratory syncytial virus bronchiolitis, postinfectious bronchiolitis obliterans, Mac-Leod-Swyer-James-Syndrome
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 23.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 13 |
| PHASE4 | 5 |
| PHASE3 | 3 |
| PHASE2/PHASE3 | 1 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01660867 | PHASE4 | WITHDRAWN | Nebulized 3% Hypertonic Saline in the Treatment of Acute Bronchiolitis in the Emergency Department |
| NCT01871857 | PHASE4 | COMPLETED | 7% Hypertonic Saline for Acute Bronchiolitis |
| NCT03880903 | PHASE4 | UNKNOWN | Hypertonic Saline Inhalation in Acute Bronchiolitis |
| NCT04613180 | PHASE4 | UNKNOWN | Evaluation of the Effectiveness of Montelukast in Children With Recurrent Obstructive Bronchitis |
| NCT06441162 | PHASE4 | TERMINATED | Efficacy Of Combined Nebulized Hypertonic Saline and Chest Percussion Therapy in Acute Viral Bronchiolitis |
| NCT01469845 | PHASE3 | COMPLETED | The SABRE Trial of Hypertonic Saline in Acute Bronchiolitis |
| NCT01875757 | PHASE3 | COMPLETED | Effect of Supplementation With Vitamin D on the Acute Bronchitis Prevention During the First Year of Life |
| NCT03171142 | PHASE3 | COMPLETED | Effect of Heliox on RSV Bronchiolitis |
| NCT06558461 | PHASE2/PHASE3 | COMPLETED | Nebulised 3% Hypertonic Saline in Infants With Acute Bronchiolitis |
| NCT06139029 | EARLY_PHASE1 | COMPLETED | Comparison of 3% Normal Saline Nebulization Versus Steroid Nebulization in the Treatment of Bronchiolitis |
| NCT06321133 | Not specified | RECRUITING | High Flow Nasal Cannula Weaning in Acute Bronchiolitis |
| NCT06636955 | Not specified | RECRUITING | Viral Epidemiology of Bronchiolitis After Nirsevimab Implementation and Respiratory Evolution in Infants |
| NCT07138625 | Not specified | NOT_YET_RECRUITING | Nebulized 3% Hypertonic Saline Versus Normal Saline in Managing Children With Acute Bronchiolitis: A Randomized Controlled Trial |
| NCT07359287 | Not specified | RECRUITING | Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary Care |
| NCT07505420 | Not specified | NOT_YET_RECRUITING | Risk Factors and Severity of Bronchiolitis in Hospitalized Children at Assiut University Hospital |
| NCT02029040 | Not specified | COMPLETED | Nebulized 3% Hypertonic Saline in the Treatment of Acute Bronchiolitis |
| NCT02093715 | Not specified | UNKNOWN | FeNO and Cytokines in Respiratory Syncytial Virus (RSV) and Non RSV Bronchiolitis in Relation to Future Asthma |
| NCT02962505 | Not specified | COMPLETED | Continuous Regional Analysis Device for Neonate Lung |
| NCT02984046 | Not specified | UNKNOWN | Acute Bronchiolitis and Severity Markers: Interest in Protein CC16 |
| NCT03753802 | Not specified | UNKNOWN | Evaluation of the Effects of Respiratory Physiotherapy in Infants With Moderate Acute Bronchiolitis |
| NCT03915197 | Not specified | UNKNOWN | Acute Bronchiolitis in Infants and Allergic Asthma |
| NCT04245202 | Not specified | COMPLETED | Comparison of High Flow Nasal Cannula and Standard Face Mask Oxygen Therapy in Children With Bronchiolitis |
| NCT04748159 | Not specified | COMPLETED | Effects of Prone Positioning on Vital Parameters in Infants With Acute Bronchiolitis |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| MONTELUKAST | 4 | 3 |
| SODIUM CHLORIDE | 4 | 3 |
| ALBUTEROL | 4 | 1 |
| BETAMETHASONE | 4 | 1 |
| DEXAMETHASONE | 4 | 1 |
| EPINEPHRINE | 4 | 1 |
| RACEPINEPHRINE | 2 | 1 |
| CHEMBL5430305 | 0 | 1 |
| CHEMBL1230914 | 0 | 1 |
| AIR, MEDICAL | -1 | 1 |