Acute cholangitis

disease

On this page

Also known as cholangitis, acute

Summary

Acute cholangitis (MONDO:0001930) is a disease and 11 clinical trials. Top therapeutic interventions include water. A subtype of cholangitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

Clinical trials: 11

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	acute cholangitis
Mondo ID	MONDO:0001930
DOID	DOID:14271
NCIT	C35334
SNOMED CT	6215006
UMLS	C0267917
MedGen	82764
Is cancer (heuristic)	no

Also known as: acute cholangitis · cholangitis, acute

Disease family

This is a subtype of cholangitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › digestive system disorder › hepatobiliary disorder › biliary tract disorder › bile duct disorder › non-neoplastic bile duct disorder › cholangitis › acute cholangitis

Subtypes (1): acute cholecystitis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 11.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	9
PHASE2	1
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT07407491	PHASE2	RECRUITING	Comparative Efficacy Of Intraductal Antibiotic During ERCP In Acute Cholangitis
NCT02070627	PHASE1	COMPLETED	Near Infrared Fluorescence Cholangiography (NIRF-C) During Cholecystectomy – Use in Acute Cholecystitis Sub-Study
NCT02601417	Not specified	ACTIVE_NOT_RECRUITING	The Necessity of Bile Cultures in Patients With Acute Cholangitis
NCT06011941	Not specified	NOT_YET_RECRUITING	Modified Laparoscopic Transcystic Biliary Drainage in the Management of Cholecystocholedocholithiasis
NCT07379749	Not specified	NOT_YET_RECRUITING	Impact of Positive Bile Cultures on Plastic Biliary Stent Exchange
NCT01706068	Not specified	UNKNOWN	Transient ECG Changes in Patients With Acute Biliary Disease
NCT03422042	Not specified	COMPLETED	Short Duration Versus Fourteen Days Antibiotic in Common Bile Duct Cholangitis
NCT04173286	Not specified	UNKNOWN	Is Short Antibiotherapy Duration After Drainage Suitable for Patients Admitted in Intensive Care Medicine With a Severe Acute Cholangitis?
NCT04922528	Not specified	UNKNOWN	Visualization of the Extrahepatic biliaRy Tree Trial
NCT05920954	Not specified	COMPLETED	Urgent (<24 Hours) Versus Early (24 to 48 Hours) ERCP for Patients With Mild and Moderate Acute Cholangitis
NCT07064980	Not specified	COMPLETED	ERCP Versus PTBD for Severe Acute Cholangitis Caused by Bile Duct Stones

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
WATER	4	1

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.