Acute cystitis

disease

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Also known as acute cystitis (disease)cystitis, acute

Summary

Acute cystitis (MONDO:0001650) is a disease with 2 GWAS associations across 5 studies and 4 clinical trials. Top therapeutic interventions include amdinocillin, ciprofloxacin, and ibuprofen. A subtype of bacterial urinary tract infection — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

GWAS associations: 2
Clinical trials: 4

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	acute cystitis
Mondo ID	MONDO:0001650
DOID	DOID:13148
ICD-10-CM	N30.0
NCIT	C26934
SNOMED CT	68226007
UMLS	C0149523
MedGen	57429
Is cancer (heuristic)	no

Also known as: acute cystitis · acute cystitis (disease) · cystitis, acute

Data availability: 2 GWAS associations (5 studies).

Disease family

This is a subtype of bacterial urinary tract infection. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › bacterial infectious disease › bacterial urinary tract infection › acute cystitis

Subtypes (1): acute gonococcal cystitis

Genetics & variants

GWAS landscape

2 GWAS associations across 5 studies. Top hits map to 1 distinct genes (as reported by GWAS).

Top associations by p-value

rsID	p-value	Gene	Risk allele	Odds ratio
rs576277880	2e-11	RNU6-627P - FIGN	G	2.67
rs151283019	5e-08	ASTN2	?

Top studies (by case count)

Study	Lead author	Year	Cases	Controls	Title
GCST90478555	Verma A	2024	1,754	443,631	Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
GCST90651698	Liu TY	2025	515	192,000	Diversity and longitudinal records: Genetic architecture of disease associations and polygenic risk in the Taiwanese Han population.
GCST90480391	Verma A	2024	473	119,492	Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
GCST90482216	Verma A	2024	473	119,492	Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
GCST90436432	Zhou W	2018	138	379,936	Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies.

Variant details and genetic-evidence tiers

Tier distribution (top 50 variants)

Tier	Variants
Tier 1: coding	0
Tier 2: splice/UTR	0
Tier 3: regulatory	0
Tier 4: intronic/intergenic	2

MAF distribution

Bucket	Variants
common (>=0.05)	1
low_freq (0.01-0.05)	0
rare (<0.01)	1
unknown	0

Functional consequences

Consequence	Count
intron_variant	2

Top variants

rsID	Chr	Pos	Alleles	MAF	Consequence	Gene	p-value	Tier
rs576277880	2	163462671	G>C	0.001	intron_variant	RNU6-627P - FIGN	2e-11	Tier 4: intronic/intergenic
rs151283019	9	117040718	C>A,G	0.05	intron_variant	ASTN2	5e-08	Tier 4: intronic/intergenic

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 4.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	3
PHASE4	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT01849926	PHASE4	COMPLETED	Ibuprofen Versus Mecillinam for Uncomplicated Cystitis
NCT07118748	Not specified	NOT_YET_RECRUITING	Dispensing of Antibiotics in Pharmacies for Cystitis According to a Delegation Protocol, Impact of a Decision Support Tool. PHARIBO: PHarmacy and Resolved Antibiotherapy for Urinary Tract Infections
NCT01631955	Not specified	COMPLETED	Assessment of UTI Symptoms and Quality of Life According to Antibiotics Treatment in Acute Uncomplicated Cystitis
NCT03517215	Not specified	UNKNOWN	The Development and Testing of a Scaling Strategy for a Community-Based Primary Care Antimicrobial Stewardship Program

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
AMDINOCILLIN	4	1
CIPROFLOXACIN	4	1
IBUPROFEN	4	1
CHEMBL4750793	0	1

Drugs: Amdinocillin, Ciprofloxacin, Ibuprofen