Acute diarrhea
disease diseaseOn this page
Also known as acute diarrheal diseasediarrhea (disease), acutediarrhea, acutediarrheal disease, acutediarrhoea (disease), acute
Summary
Acute diarrhea (MONDO:0000257) is a disease and 24 clinical trials. Top therapeutic interventions include racecadotril, zinc sulfate, and montmorillonite. A subtype of diarrheal disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 24
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | acute diarrhea |
| Mondo ID | MONDO:0000257 |
| DOID | DOID:0050140 |
| SNOMED CT | 409966000 |
| UMLS | C0740441 |
| MedGen | 677005 |
| Is cancer (heuristic) | no |
Also known as: acute diarrheal disease · diarrhea (disease), acute · diarrhea, acute · diarrheal disease, acute · diarrhoea (disease), acute
Disease family
This is a subtype of diarrheal disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › digestive system disorder › diarrheal disease › acute diarrhea
Related subtypes (6): secretory diarrhea, diarrheal disease secondary to altered bowel motility, inflammatory diarrhea, congenital diarrhea, chronic diarrheal disease, non-infectious diarrheal disease
Subtypes (1): dysentery
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 24.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 16 |
| PHASE4 | 6 |
| PHASE2 | 1 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01564290 | PHASE4 | COMPLETED | Use of Probiotic Yogurt in the Treatment of Acute Diarrhea in Children |
| NCT01571856 | PHASE4 | COMPLETED | Efficacy of Use of Zinc in the Treatment of Acute Diarrhea in Infants |
| NCT01577043 | PHASE4 | COMPLETED | Efficacy of Racecadotril in Acute Watery Diarrhea in Children |
| NCT01927094 | PHASE4 | COMPLETED | Effects of Probiotics and/or Prebiotics on the Duration of Diarrhea and Hospitalization in Children |
| NCT02704091 | PHASE4 | COMPLETED | Efficacy of Diosmectite (Smecta®) in the Symptomatic Treatment of Acute Diarrhoea in Adults |
| NCT03356327 | PHASE4 | COMPLETED | Oral Administration of Tannins and Flavonoids in Children With Acute Diarrhea |
| NCT01269892 | PHASE2 | COMPLETED | Early Administration of Lactose-free Milk in Children Presenting With Acute Diarrhea |
| NCT01376440 | PHASE1 | COMPLETED | Acceptability and Effectiveness of Household Water Treatment in Reducing Diarrhea Among Under Five Children |
| NCT00429325 | Not specified | COMPLETED | Fecal Calprotectin: Cheap Marker for Diagnosing Acute Infectious Diarrhea |
| NCT00895492 | Not specified | COMPLETED | Two-year Surveillance of Rotavirus Genotypes Causing Acute Diarrhea in Children Younger Than 5 Years Requiring Emergency Room (ER) and Hospital Admission in Chile |
| NCT00963391 | Not specified | COMPLETED | Alcohol Based Hand Sanitizers for the Prevention of Acute Diarrheal Disease and Acute Respiratory Infection in Children Under 5 Attending Childcare Centers in Bogotá, Cundinamarca and Tolima, in Colombia: a Cluster Randomized Control Trial |
| NCT01273012 | Not specified | UNKNOWN | Cost-effectiveness of Infloran (TM) in Treating Acute Childhood Diarrhea in Phramongkutklao Hospital |
| NCT01814202 | Not specified | COMPLETED | Study With Medical Nutrition Product PTM202 in Pediatric Diarrhea |
| NCT02817165 | Not specified | TERMINATED | Probiotics for the Prevention of Antibiotic-Associated Diarrhea |
| NCT02896465 | Not specified | COMPLETED | Human Milk Oligosaccharides and Childhood Diarrhoea |
| NCT03598010 | Not specified | UNKNOWN | Safety, Tolerability and Preliminary Efficacy of Lenodiar Pediatric in Diarrhea |
| NCT03684538 | Not specified | COMPLETED | Efficacy Of Probiotics vs. Zinc vs. Probiotics-Zinc Combination On Acute Diarrhea In Children |
| NCT03943654 | Not specified | COMPLETED | Improving Nighttime Access to Care and Treatment (Part 2) |
| NCT04039828 | Not specified | COMPLETED | Zinc Sulfate Acceptability |
| NCT04237181 | Not specified | COMPLETED | Results of FilmArray® Gastro-intestinal Panel and Serum Procalcitonin in Acute Colitis and Infectious Diarrhea in the ER |
| NCT04796480 | Not specified | COMPLETED | Comparison Of Outcome Of Lactose Free Formula Milk With Yogurt In Children With Acute Diarrhea |
| NCT05183789 | Not specified | UNKNOWN | IL6&8 in Malnourished Children With Acute Diarrhea |
| NCT05213325 | Not specified | UNKNOWN | Evaluation of Serum Interleukin 6 and 8 in Children With Acute Gastroenteritis |
| NCT05345028 | Not specified | COMPLETED | Boswellia Serrata Extract in Acute Diarrhea |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| RACECADOTRIL | 4 | 1 |
| ZINC SULFATE | 4 | 1 |
| MONTMORILLONITE | 3 | 1 |
| ECADOTRIL | 2 | 1 |
| CHEMBL1201279 | 0 | 2 |
Related Atlas pages
- Drugs: Racecadotril, Zinc, Montmorillonite