Acute disease
disease diseaseOn this page
Also known as acute diseasesdisease, acute
Summary
Acute disease (MONDO:0020683) is a disease (an umbrella term covering 119 Mondo subtypes) and 47 clinical trials. Top therapeutic interventions include abciximab, ascorbic acid, and ertapenem. A subtype of human disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Umbrella term: 119 Mondo subtypes
- Clinical trials: 47
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | acute disease |
| Mondo ID | MONDO:0020683 |
| MeSH | D000208 |
| SNOMED CT | 2704003 |
| UMLS | C0001314 |
| MedGen | 1738 |
| Is cancer (heuristic) | no |
Also known as: acute disease · acute diseases · disease, acute
Disease family
An umbrella term covering 119 Mondo subtypes.
Classification path: disease › human disease › acute disease
Related subtypes (3): disease by body system or component, disease by developmental or physiological process, disease by etiologic mechanism
Subtypes (119): encephalopathy, acute, infection-induced, seminal vesicle acute gonorrhea, acute diarrhea, acute hydrops keratoconus, acute pericementitis, purulent acute otitis media, acute otitis externa, acute eustachian salpingitis, acute cervicitis, acute gonococcal epididymo-orchitis, acute salpingitis, acute respiratory failure, acute conjunctivitis, acute laryngopharyngitis, acute orbital inflammation, acute dacryocystitis, acute sphenoidal sinusitis, acute proliferative glomerulonephritis, acute cystitis, acute tympanitis, acute closed-angle glaucoma, acute gonococcal prostatitis, acute poststreptococcal glomerulonephritis, acute diffuse glomerulonephritis, acute retrobulbar neuritis, acute frontal sinusitis, acute cholangitis, acute thyroiditis, acute maxillary sinusitis, acute kidney injury, acute transudative otitis media, acute myocarditis, subacute glomerulonephritis, acute pyelonephritis, acute urate nephropathy, acute stress disorder, acute inflammation of lacrimal passage, acute endometritis, acute cor pulmonale, acute intestinal ischemia, subacute delirium, acute laryngitis, acute myocardial infarction, acute ethmoiditis, acute dacryoadenitis, acute female pelvic peritonitis, acute quadriplegic myopathy, severe acute respiratory syndrome, acute hypotension, acute coronary syndrome, acute chest syndrome, acute pancreatitis, acute retinal necrosis syndrome, subacute bacterial endocarditis, necrotizing encephalomyelopathy, subacute, of Leigh, adult, acute intermittent porphyria, leukemia, acute myelocytic, with polyposis coli and colon cancer, surfactant metabolism dysfunction, pulmonary, 1, myoglobinuria, acute recurrent, autosomal recessive, acute leukemia, acute insulin response, alcohol sensitivity, acute, leukemia, acute lymphocytic, susceptibility to, 1, leukemia, acute lymphocytic, susceptibility to, 2, acute infantile liver failure-cerebellar ataxia-peripheral sensory motor neuropathy syndrome, acute transverse myelitis, subacute cutaneous lupus erythematosus, acute lung injury, subacute inflammatory demyelinating polyneuropathy, Marburg acute multiple sclerosis, acute pure sensory neuropathy, autoimmune autonomic ganglionopathy, acute sensory ataxic neuropathy, acute fatty liver of pregnancy, acute neonatal citrullinemia type I, acute endophthalmitis, acute zonal occult outer retinopathy, acute annular outer retinopathy, poliomyelitis, acute generalized exanthematous pustulosis, acute opioid poisoning, acute encephalopathy with biphasic seizures and late reduced diffusion, acute tricyclic antidepressant poisoning, acute poisoning by drugs with membrane-stabilizing effect, recurrent acute pancreatitis, bilateral acute depigmentation of the iris, idiopathic acute eosinophilic pneumonia, acute ackee fruit intoxication, acute interstitial pneumonia, acute liver failure, acute adrenal insufficiency, encephalitis, acute inflammatory demyelinating polyradiculoneuropathy, acute motor and sensory axonal neuropathy, acute motor axonal neuropathy, acute graft versus host disease, acute pharyngitis, sudden hearing loss disorder, acute bronchiolitis, acute tonsillitis, acute rheumatic heart disease, acute cholinergic dysautonomia, acute mountain sickness, acute lymphoblastic leukemia congenital sporadic aniridia, acute lichenoid pityriasis, leukoencephalopathy, acute reversible, with increased urinary alpha-ketoglutarate, acute radiation syndrome, acute bilirubin encephalopathy, acute mast cell leukemia, subacute bursitis, acute papillary necrosis, acute posterior multifocal placoid pigment epitheliopathy, acute idiopathic urticaria, acute macular neuroretinopathy, acute flaccid myelitis, acute hepatitis B virus infection, acute hepatitis C virus infection, acute fibrinous and organizing pneumonia, acute transplant rejection
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated or in trials for this disease
No drug has an approved disease-direct ChEMBL indication for this disease.
2 drugs in clinical trials for this disease (phase 2–3, investigational): efficacy not established — a trial record, not an indication.
| Drug | Highest phase |
|---|---|
| Abciximab | Phase 3 |
| Bivalirudin | Phase 3 |
Clinical trials & evidence
Clinical trials
Clinical trials: 47.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 40 |
| PHASE4 | 2 |
| PHASE3 | 2 |
| PHASE2 | 2 |
| PHASE2/PHASE3 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00097734 | PHASE4 | UNKNOWN | Study to Evaluate the Duration of Treatment With Ertapenem in Acute Attacks of Sigmoid Diverticulitis |
| NCT01050478 | PHASE4 | COMPLETED | IMPACT: A Study to Explore the Efficacy and Safety of Paliperidone ER in Patients With Acute Agitation |
| NCT06949228 | PHASE2/PHASE3 | RECRUITING | Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy (ALLY) II Trial |
| NCT00073372 | PHASE3 | TERMINATED | A Study of Effectiveness and Safety of Abciximab in Patients With Acute Ischemic Stroke (AbESTT-II) |
| NCT00093158 | PHASE3 | COMPLETED | Comparison of Angiomax Versus Heparin in Acute Coronary Syndromes (ACS) |
| NCT00607997 | PHASE2 | COMPLETED | Study of Voreloxin (Vosaroxin) in Older Patients With Untreated Acute Myeloid Leukemia |
| NCT00715962 | PHASE2 | COMPLETED | Efficacy and Safety of a Hospital Walking Program for Older Adults |
| NCT04420832 | Not specified | ACTIVE_NOT_RECRUITING | Acute Achilles Tendon Rupture - Choice of Treatment Based on Ultrasound Findings |
| NCT04615065 | Not specified | RECRUITING | Acutelines: a Large Data-/Biobank of Acute and Emergency Medicine |
| NCT05913700 | Not specified | ACTIVE_NOT_RECRUITING | Effect of Respiratory Virus Infection on EmeRgencY Admission Study (EVERY Study) |
| NCT06315842 | Not specified | NOT_YET_RECRUITING | Levels of Diagnostic and Therapeutic Intervention in Hospitalized Patients |
| NCT06655337 | Not specified | RECRUITING | Efficiency of the Medidux Smartphone App for Demission Management in Patients Medicated in Acute Admission Unit (AAU) |
| NCT06901167 | Not specified | RECRUITING | Evaluation of a Residential In-Reach Program in Regional and Rural Australia |
| NCT06983847 | Not specified | RECRUITING | A Long-term Observational Study to Describe the Use of Vitamin-C Injektopas® 7.5 g in Patients With Vitamin C Deficiency |
| NCT07007156 | Not specified | RECRUITING | Is a Positive NECPAL in ICU Patients Associated With Higher Mortality |
| NCT07278648 | Not specified | NOT_YET_RECRUITING | High-risk Antithrombotic Drugs at Discharge and Consultation for Hemorrhagic or Thromboembolic Events in the Emergency Department |
| NCT07472335 | Not specified | NOT_YET_RECRUITING | Home-based Acute Care for Older Persons Initiated by the Emergency Medical and Ambulance Services - a Retrospective Observation of Effects on Healthcare Utilisation and Mortality |
| NCT00186342 | Not specified | COMPLETED | Sibling and Unrelated Donor Hematopoietic Cell Transplant in Hematologic Malignancies |
| NCT00461201 | Not specified | UNKNOWN | Nurse vs General Practitioner Care for Patients Requesting Same Day Consultations in Primary Care |
| NCT00563654 | Not specified | TERMINATED | Randomized Trial Comparing Alfuzosin GITS 10 mg Daily With Placebo for Trial Without Catheter in Acute Urinary Retention With Long Term Follow up |
| NCT01108172 | Not specified | UNKNOWN | A Virtual Ward to Reduce Readmissions After Hospital Discharge |
| NCT01278199 | Not specified | COMPLETED | Bronchial Artery Embolization and Medical Measures in Non Severe Acute Hemoptysis of Mild-moderate Abundance |
| NCT01506180 | Not specified | COMPLETED | In-Hospital Comprehensive Geriatric Assessment in Aged Acute Medical Patients |
| NCT02422901 | Not specified | UNKNOWN | A Long-term Study to Describe the Use of PASCORBIN® 7.5 g in Patients With Vitamin C Deficiency |
| NCT02474277 | Not specified | COMPLETED | How Well Does the 30-Second Chair Stand Test Predict Rehabilitation Needs in Acutely Admitted Elderly Patients |
| NCT02533869 | Not specified | COMPLETED | The Optimization of a Low-dose Computed Tomography Protocol in Patients With Suspected Uncomplicated Acute Appendicitis |
| NCT02568475 | Not specified | COMPLETED | Involving Nursing Home Residents and Their Families in Acute Care Transfer Decisions |
| NCT02688244 | Not specified | UNKNOWN | Irrigation Versus Suction in Complicated Acute Appendicitis |
| NCT02800122 | Not specified | UNKNOWN | PAthwAy of Dyspneic patIent in Emergency (PArADIsE) |
| NCT02912624 | Not specified | COMPLETED | Simple Intensive Care Studies I (SICS-I) |
| NCT02915640 | Not specified | COMPLETED | Use of a Mobile Remote Device to Optimize Pediatric Inter-facility Transportation: A Feasibility Study |
| NCT02917213 | Not specified | COMPLETED | Imaging Silent Brain Infarct And Thrombosis in Acute Myocardial Infarction |
| NCT03175692 | Not specified | UNKNOWN | Rapid Genetic Diagnosis Employing Next Generation Sequencing for Critical Illness in Infants and Children |
| NCT03553069 | Not specified | COMPLETED | Simple Observational Critical Care Studies |
| NCT03607084 | Not specified | COMPLETED | School-based Health Programs on Children’s Wellbeing in Lusaka, Zambia |
| NCT03832257 | Not specified | COMPLETED | Improving Safety of Transitions to Skilled Nursing Care Using Videoconferencing |
| NCT03892850 | Not specified | UNKNOWN | Effectiveness and Safety of the Nursing Prescription in Acute Health Problems of Low Complexity |
| NCT03982589 | Not specified | COMPLETED | Telomere Length in Relation to Acute Stress Response in Critical Care Patients |
| NCT04326387 | Not specified | UNKNOWN | Evaluation of Novel Diagnostic Tests for COVID-19 |
| NCT04519086 | Not specified | SUSPENDED | The Optimization of a Low-dose CT Protocol in Patients With Suspected Uncomplicated Acute Appendicitis and BMI >30 |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| ABCIXIMAB | 4 | 1 |
| ASCORBIC ACID | 4 | 1 |
| ERTAPENEM | 4 | 1 |
| FIBRINOGEN I 125 | 4 | 1 |
| TENECTEPLASE | 4 | 1 |
| BENZODIAZEPINE | 3 | 1 |
| VOSAROXIN | 3 | 1 |