Acute inflammatory demyelinating polyradiculoneuropathy
disease diseaseOn this page
Also known as acute idiopathic demyelinating polyneuropathyacute inflammatory demyelinating polyradiculopathyacute inflammatory polyneuropathyAIDPGBS, acute inflammatory demyelinating polyradiculoneuropathic formGuillain-Barre syndrome, acute inflammatory demyelinating polyradiculoneuropathic formGuillain-Barré syndrome, acute inflammatory demyelinating polyradiculoneuropathic form
Summary
Acute inflammatory demyelinating polyradiculoneuropathy (MONDO:0020347) is a disease and 3 clinical trials. A subtype of Guillain-Barre syndrome — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: 1-9 / 100 000 (Europe) [Orphanet-validated]
- Phenotypes (HPO): 13
- Clinical trials: 3
Clinical features
Epidemiology
Prevalence records
1 prevalence record(s), Orphanet:
| Type | Class | Value | Geography | Validation |
|---|---|---|---|---|
| Point prevalence | 1-9 / 100 000 | 3.1 | Europe | Validated |
Signs & symptoms
Clinical features (HPO)
13 HPO clinical features (Orphanet curated; top 13 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0007131 | Acute demyelinating polyneuropathy | Obligate (100%) |
| HP:0001265 | Hyporeflexia | Frequent (30-79%) |
| HP:0001290 | Generalized hypotonia | Frequent (30-79%) |
| HP:0001954 | Recurrent fever | Frequent (30-79%) |
| HP:0002307 | Drooling | Frequent (30-79%) |
| HP:0002317 | Unsteady gait | Frequent (30-79%) |
| HP:0003445 | EMG: neuropathic changes | Frequent (30-79%) |
| HP:0005335 | Sleepy facial expression | Frequent (30-79%) |
| HP:0009053 | Distal lower limb muscle weakness | Frequent (30-79%) |
| HP:0012534 | Dysesthesia | Frequent (30-79%) |
| HP:0031162 | Impaired oropharyngeal swallow response | Frequent (30-79%) |
| HP:0003383 | Onion bulb formation | Occasional (5-29%) |
| HP:0002066 | Gait ataxia | Excluded (0%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | acute inflammatory demyelinating polyradiculoneuropathy |
| Mondo ID | MONDO:0020347 |
| Orphanet | 98916 |
| ICD-11 | 1196874419 |
| NCIT | C116926 |
| UMLS | C4551910 |
| MedGen | 1648220 |
| GARD | 0016873 |
| Is cancer (heuristic) | no |
Also known as: acute idiopathic demyelinating polyneuropathy · acute inflammatory demyelinating polyradiculopathy · acute inflammatory polyneuropathy · AIDP · GBS, acute inflammatory demyelinating polyradiculoneuropathic form · Guillain-Barre syndrome, acute inflammatory demyelinating polyradiculoneuropathic form · Guillain-Barré syndrome, acute inflammatory demyelinating polyradiculoneuropathic form
Disease family
This is a subtype of Guillain-Barre syndrome. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › nervous system disorder › autoimmune disorder of the nervous system › autoimmune disorder of peripheral nervous system › Guillain-Barre syndrome › acute inflammatory demyelinating polyradiculoneuropathy
Related subtypes (10): Guillain-Barre syndrome, familial, pharyngeal-cervical-brachial variant of Guillain-Barre syndrome, paraparetic variant of Guillain-Barre syndrome, acute pure sensory neuropathy, autoimmune autonomic ganglionopathy, acute sensory ataxic neuropathy, facial diplegia with paresthesias, acute motor and sensory axonal neuropathy, acute motor axonal neuropathy, polyneuropathy, inflammatory demyelinating, chronic
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 3.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 3 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT07333196 | Not specified | NOT_YET_RECRUITING | Tongji NADs Cohort |
| NCT01469858 | Not specified | UNKNOWN | Perception and Multisensory Integration in Neurological Patients Using fMRI |
| NCT02722070 | Not specified | UNKNOWN | Processing Integration in Neurological Patients Using fMRI |
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.