Acute mountain sickness

Summary

Acute mountain sickness (MONDO:0021811) is a disease and 76 clinical trials. Top therapeutic interventions include acetazolamide, prochlorperazine, and theophylline anhydrous. A subtype of altitude sickness — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 76

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	acute mountain sickness
Mondo ID	MONDO:0021811
SNOMED CT	78590007
UMLS	C0238284
MedGen	536790
Is cancer (heuristic)	no

Also known as: acute mountain sickness · altitude anoxia · altitude sickness · high altitude cerebral edema · high altitude cerebral oedema · high altitude pulmonary edema · high altitude pulmonary oedema · Mountain sickness

Disease family

This is a subtype of altitude sickness. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › respiratory system disorder › altitude sickness › acute mountain sickness

Related subtypes (1): chronic mountain sickness

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 76.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	40
PHASE4	13
PHASE3	7
PHASE1	6
PHASE2	4
PHASE1/PHASE2	3
PHASE2/PHASE3	2
EARLY_PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT07118462	PHASE4	RECRUITING	HighCycle Study: Acetazolamide, High Altitude and Plasma Volume
NCT00627965	PHASE4	COMPLETED	Randomized, Controlled Trial of Regular Sildenafil Citrate in the Prevention of Altitude Illness
NCT01418157	PHASE4	COMPLETED	A Trial of Acetazolamide Versus Placebo in Preventing Mountain Sickness During Rapid Ascent
NCT01665781	PHASE4	COMPLETED	Erythropoietin in the Prevention of Acute Mountain Sickness
NCT02024386	PHASE4	COMPLETED	Efficacy Study of Riociguat and Its Effects on Exercise Performance and Pulmonary Artery Pressure at High Altitude
NCT02463357	PHASE4	COMPLETED	Three New Ideas to Protect Special Forces From the Stress of High Altitude
NCT02760121	PHASE4	COMPLETED	AZ, MZ, and the Pulmonary System Response to Hypoxia
NCT03490916	PHASE4	TERMINATED	Effect of Acetazolamide on Subclinical High-Altitude Pulmonary Edema Detected by Lung Ultrasonography
NCT03561675	PHASE4	COMPLETED	Effect of Acetazolamide on Acute Mountain Sickness in Lowlanders Older Than 40 Years
NCT05023941	PHASE4	COMPLETED	Optimization Strategy for the Prevention of AMS by RIPC Combined With Acetazolamide
NCT05734716	PHASE4	COMPLETED	Colorado-Oregon Altitude Study
NCT06310642	PHASE4	COMPLETED	Efficacy of Prophylactic Treatment of Oral Prochlorperazine for Acute Mountain Sickness
NCT06499727	PHASE4	COMPLETED	HighCycle Study: Effect of Acetazolamide on Acute Mountain Sickness in Women Compared to Men
NCT06531161	PHASE2/PHASE3	NOT_YET_RECRUITING	EleVation carE: a Randomized Controlled Trial on the Prevention of Acute Mountain Sickness With Suxiao Jiuxin Pill
NCT00664001	PHASE3	COMPLETED	Anti-Oxidant Supplementation for the Prevention of Acute Mountain Sickness
NCT01171794	PHASE3	COMPLETED	Prevention of Altitude Illness With Non-steroidal Anti-inflammatory Study (PAINS)
NCT01902758	PHASE2/PHASE3	COMPLETED	Drug Combination on Exercise Performance at High Altitude
NCT02604173	PHASE3	COMPLETED	Altitude Sickness Prevention and Efficacy of Comparative Treatments
NCT02941510	PHASE3	WITHDRAWN	Inhaled Budesonide for Altitude Illness Prevention
NCT04913389	PHASE3	UNKNOWN	Acetazolamide to Prevent Impending Altitude-illness in Patients With COPD
NCT04915365	PHASE3	UNKNOWN	Effect of Acetazolamide on Right Heart Function at Rest in Lowlanders With COPD Traveling to High Altitude
NCT04993729	PHASE3	COMPLETED	Safety and Efficacy of T89 in the Prevention and Treatment of Adults With Acute Mountain Sickness (AMS)
NCT00274430	PHASE1/PHASE2	COMPLETED	Prevention of High Altitude Pulmonary Edema
NCT01187108	PHASE1/PHASE2	COMPLETED	Study of Cobalt’s Role in Excessive Erythrocytosis Among High Altitude Dwellers in Cerro de Pasco, Peru
NCT01536288	PHASE2	COMPLETED	Can Rhodiola Crenulata Intake Improve Oxygen Saturation and Decrease the Incidence of Acute Mountain Sickness
NCT01682551	PHASE2	UNKNOWN	Evaluation of the Prevention and Treatment Effects of Chinese Medicine on High Altitude Illness
NCT03270787	PHASE1/PHASE2	COMPLETED	Study of Compound Danshen Dripping Pills to Treat Acute Mountain Sickness
NCT03552263	PHASE2	COMPLETED	Safety and Efficacy of T89 in Prevention and Treatment of Adults With Acute Mountain Sickness (AMS)
NCT06450899	PHASE2	COMPLETED	Prochlorperazine Maleate Versus Placebo for the Prophylaxis of Acute Mountain Sickness
NCT01587027	PHASE1	COMPLETED	Safety Evaluation of Aminophylline and Methazolamide
NCT02811016	PHASE1	COMPLETED	Inhaled Budesonide and Acute Mountain Sickness
NCT03154645	PHASE1	COMPLETED	Altitude Sickness Prevention With Ibuprofen Relative to Acetazolamide and Treatment Efficacy
NCT03341676	PHASE1	COMPLETED	Spectroscopic and Diffusion Weighted Analysis of the Effects of Dexamethasone on High Altitude Cerebral Oedema (HACE)
NCT03424226	PHASE1	COMPLETED	Sickness Evaluation at Altitude With Acetazolamide at Relative Dosages
NCT03828474	PHASE1	COMPLETED	Sickness Evaluation at Altitude With Acetazolamide at Relative Doses
NCT07517068	EARLY_PHASE1	ACTIVE_NOT_RECRUITING	The Role of Acetazolamide in Mitigating Inflammation and Innate Immune Activation at High Altitude
NCT06129825	Not specified	ACTIVE_NOT_RECRUITING	Pharmacologic Induction of Tolerance for Hypoxia & Hypothermia
NCT06499714	Not specified	RECRUITING	HighCycle Study: Effect of High Altitude on Acute Mountain Sickness in Women Related to Their Menstrual Cycle Phase
NCT07126834	Not specified	ACTIVE_NOT_RECRUITING	Voluntary Isocapnic Hyperpnea in Hypoxia to Mitigate Acute Mountain Sickness
NCT07148674	Not specified	NOT_YET_RECRUITING	Efficacy of Positive Expiratory Pressure on Acute Mountain Sickness

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
ACETAZOLAMIDE	4	11
PROCHLORPERAZINE	4	4
THEOPHYLLINE ANHYDROUS	4	4
METHAZOLAMIDE	4	3
SILDENAFIL	4	3
NIFEDIPINE	4	2
AMBRISENTAN	4	1
DIPHENHYDRAMINE	4	1
IRON SUCROSE	4	1
NITROUS ACID	4	1
RIOCIGUAT	4	1
QUERCETIN	3	1
CHEMBL4792718	0	1
CHEMBL5439651	0	1
CHEMBL302753	0	1