Acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent

Summary

Acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent (MONDO:0015164) is a cancer. A subtype of therapy related acute myeloid leukemia and myelodysplastic syndrome — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent
Mondo ID	MONDO:0015164
Orphanet	102379
ICD-11	1401970160
NCIT	C27913
UMLS	C1332234
MedGen	233970
GARD	0019835
Is cancer (heuristic)	yes

Also known as: AML and myelodysplastic syndromes related to alkylating agent

Disease family

This is a subtype of therapy related acute myeloid leukemia and myelodysplastic syndrome. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › hematopoietic and lymphoid system neoplasm › hematopoietic and lymphoid cell neoplasm › leukemia › myeloid leukemia › acute myeloid leukemia › therapy related acute myeloid leukemia and myelodysplastic syndrome › acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent

Related subtypes (2): acute myeloid leukemia and myelodysplastic syndromes related to topoisomerase type 2 inhibitor, acute myeloid leukemia and myelodysplastic syndromes related to radiation

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.