Acute myeloid leukemia and myelodysplastic syndromes related to radiation

Summary

Acute myeloid leukemia and myelodysplastic syndromes related to radiation (MONDO:0015608) is a cancer. A subtype of therapy related acute myeloid leukemia and myelodysplastic syndrome — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Prevalence: 1-9 / 1 000 000 (Worldwide) [Orphanet-validated]

Clinical features

Epidemiology

Prevalence records

1 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Annual incidence	1-9 / 1 000 000	0.3	Worldwide	Validated

Identifiers

Disease identifiers

Field	Value
Canonical name	acute myeloid leukemia and myelodysplastic syndromes related to radiation
Mondo ID	MONDO:0015608
Orphanet	164726
UMLS	C4707660
MedGen	1637827
GARD	0020057
Is cancer (heuristic)	yes

Also known as: AML and myelodysplastic syndromes related to radiation

Disease family

This is a subtype of therapy related acute myeloid leukemia and myelodysplastic syndrome. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › hematopoietic and lymphoid system neoplasm › hematopoietic and lymphoid cell neoplasm › leukemia › myeloid leukemia › acute myeloid leukemia › therapy related acute myeloid leukemia and myelodysplastic syndrome › acute myeloid leukemia and myelodysplastic syndromes related to radiation

Related subtypes (2): acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent, acute myeloid leukemia and myelodysplastic syndromes related to topoisomerase type 2 inhibitor

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.