Acute myocarditis

disease

On this page

Also known as myocarditis, acute

Summary

Acute myocarditis (MONDO:0002815) is a disease and 10 clinical trials. Top therapeutic interventions include anakinra and colchicine. A subtype of myocarditis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

Clinical trials: 10

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	acute myocarditis
Mondo ID	MONDO:0002815
DOID	DOID:3951
NCIT	C35206
SNOMED CT	46701001
UMLS	C0155686
MedGen	102339
GARD	0023253
Is cancer (heuristic)	no

Also known as: myocarditis, acute

Disease family

This is a subtype of myocarditis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › muscle tissue disorder › cardiomyopathy › intrinsic cardiomyopathy › myocarditis › acute myocarditis

Subtypes (2): toxic myocarditis, giant cell myocarditis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 10.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE3	4
Not specified	3
PHASE2/PHASE3	1
PHASE2	1
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT05855746	PHASE3	RECRUITING	Colchicine Versus Placebo in Acute Myocarditis Patients
NCT05974462	PHASE3	RECRUITING	MYTHS-MR Trial (MYocarditis THerapy With Steroids in Patients With Mildly Reduced Ejection Fraction)
NCT06522100	PHASE3	NOT_YET_RECRUITING	Corticoid Therapy in Acute Myocarditis
NCT03018834	PHASE2/PHASE3	COMPLETED	Anakinra Versus Placebo for the Treatment of Acute MyocarditIS
NCT06478667	PHASE3	COMPLETED	The Role of Levosimendan as Inotropic Agent in Acute Aluminum Phosphide-induced Cardiotoxicity
NCT05180240	PHASE2	COMPLETED	Impact of CardiolRx on Myocardial Recovery in Patients With Acute Myocarditis
NCT07481136	PHASE1	NOT_YET_RECRUITING	64Cu-GRIP B in Patients With Acute Myocarditis
NCT02187263	Not specified	UNKNOWN	German Centre for Cardiovascular Research Cardiomyopathy Register
NCT04206163	Not specified	COMPLETED	Somatostatin Receptor Imaging in Acute Myocarditis and Cardiac Sarcoidosis
NCT04375748	Not specified	COMPLETED	Hospital Registry of Acute Myocarditis: Evolution of the Proportion of Positive SARS-COV-2 (COVID19) Cases

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
ANAKINRA	4	1
COLCHICINE	4	1
CHEMBL5220618	0	1

Drugs: Anakinra, Colchicine