Acute necrotizing encephalitis

Summary

Acute necrotizing encephalitis (MONDO:0003336) is a disease and 2 clinical trials. A subtype of viral encephalitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 2

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	acute necrotizing encephalitis
Mondo ID	MONDO:0003336
DOID	DOID:5222
NCIT	C35383
SNOMED CT	111897007
UMLS	C0338418
MedGen	83264
GARD	0013233
Is cancer (heuristic)	no

Also known as: acute necrotizing encephalitis · acute necrotizing encephalopathy · ANE

Disease family

This is a subtype of viral encephalitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › encephalomyelitis › encephalitis › infectious encephalitis › viral encephalitis › acute necrotizing encephalitis

Related subtypes (11): Powassan encephalitis, acute hemorrhagic encephalitis, Colorado tick fever, eastern equine encephalitis, subacute sclerosing panencephalitis, herpes simplex encephalitis, tick-borne encephalitis, encephalitis lethargica, mosquito-borne viral encephalitis, HHV-6 encephalitis, borna virus encephalitis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 2.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT05853159	Not specified	UNKNOWN	Clinical and Radiological Prognostic Factors of Acute Necrotizing Encephalopathy in Sohag University Hospital
NCT06731790	Not specified	COMPLETED	Role of the Nuclear Pore Component RANBP2 in Inflammatory Responses to Viral Infections