Acute necrotizing pancreatitis

Summary

Acute necrotizing pancreatitis (MONDO:0850420) is a disease and 14 clinical trials. A subtype of acute pancreatitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 14

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	acute necrotizing pancreatitis
Mondo ID	MONDO:0850420
DOID	DOID:0080998
ICD-11	2063881303
UMLS	C0267941
MedGen	75645
Is cancer (heuristic)	no

Disease family

This is a subtype of acute pancreatitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › digestive system disorder › pancreas disorder › pancreatitis › acute pancreatitis › acute necrotizing pancreatitis

Related subtypes (1): acute hemorrhagic pancreatitis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 14.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	12
PHASE4	1
PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00995098	PHASE4	COMPLETED	Early Enteral Nutrition for Severe Acute Pancreatitis
NCT07441824	PHASE3	RECRUITING	Pancreatic Enzyme Replacement in Acute Necrotizing Pancreatitis
NCT07080697	Not specified	RECRUITING	A Study to Evaluate Splenectomy on Debridement for Acute Necrotizing Pancreatitis With Pancreatic Sinistral Portal Hypertension
NCT07253350	Not specified	RECRUITING	Effectiveness of Endorotor PED® System Versus Conventional Endoscopic Techniques for the Management of Walled-off Pancreatic Necrosis in Acute Necrotizing Pancreatitis: Randomized Single-blinded Controlled Superiority Trial and Cost-utility Analysis
NCT07308600	Not specified	NOT_YET_RECRUITING	Integrating Plasma Metagenomics and Host Response for Accurate Diagnosis of Infected Pancreatic Necrosis in a Prospective Multicenter Cohort of Acute Necrotizing Pancreatitis
NCT01767233	Not specified	UNKNOWN	Prophylactic Pancreatic Duct Stenting in Acute Necrotizing Pancreatitis
NCT02641964	Not specified	COMPLETED	Risk Factors for ARDS in Patients With Acute Necrotizing Pancreatitis
NCT03234166	Not specified	COMPLETED	Acute Necrotizing Pancreatitis and Infected Pancreatic Necrosis
NCT03253861	Not specified	COMPLETED	PancRea: Risk Factors and Outcomes of Infected Pancreatic Necrosis
NCT03411629	Not specified	COMPLETED	Significance of Collections Around Colon in Patients With Acute Necrotizing Pancreatitis
NCT04479228	Not specified	UNKNOWN	Plastic Stents vs. NAGI Bi-flanged Metal Stent for Endoscopic Ultrasound Guided Drainage of Walled-off Necrosis
NCT04642794	Not specified	COMPLETED	Acute Pancreatitis and Thrombosis (PATHRO)
NCT05716633	Not specified	UNKNOWN	Tracking ENcapsulation of Pancreatic Collections in Acute Necrotizing Pancreatitis
NCT05898048	Not specified	COMPLETED	CMV Reactivation in Acute Necrotizing Pancreatitis