Acute otitis externa

Summary

Acute otitis externa (MONDO:0001051) is a disease and 12 clinical trials. Top therapeutic interventions include ciprofloxacin, dexamethasone, and finafloxacin. A subtype of otitis externa — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 12

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	acute otitis externa
Mondo ID	MONDO:0001051
DOID	DOID:10518
SNOMED CT	30250000
UMLS	C0149948
MedGen	508459
Is cancer (heuristic)	no

Also known as: acute otitis externa · acute swimmers’ ear · otitis externa, acute

Disease family

This is a subtype of otitis externa. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › auditory system disorder › external ear disorder › otitis externa › acute otitis externa

Related subtypes (3): otomycosis, malignant otitis externa, perichondritis of auricle

Subtypes (2): acute infection of pinna, acute perichondritis of pinna

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 12.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE3	9
PHASE2	2
Not specified	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00750633	PHASE3	COMPLETED	A Phase III Study of an Otic Formulation in Acute Otitis Externa
NCT00945802	PHASE3	TERMINATED	FST-201 In The Treatment of Acute Otitis Externa
NCT00961675	PHASE3	COMPLETED	FST-201 in the Treatment of Acute Otitis Externa
NCT01535560	PHASE3	COMPLETED	Safety and Efficacy Evaluation of Topical AL-60371 Otic Suspension, 0.3% in the Treatment of Acute Otitis Externa
NCT01535599	PHASE3	COMPLETED	Safety and Efficacy Evaluation of Topical AL-60371 Otic Suspension, 0.3% in the Treatment of Acute Otitis Externa
NCT02216071	PHASE3	COMPLETED	Comparative Efficacy and Safety of Ciprofloxacin 0.3% and Dexamethasone 0.1% in Acute Otitis Externa
NCT02801370	PHASE3	COMPLETED	Phase 3 Study of OTO-201 in Acute Otitis Externa
NCT03196973	PHASE3	COMPLETED	Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Acute Otitis Externa
NCT04636957	PHASE3	UNKNOWN	A Phase III Study of Ciprofloxacin Plus Fluocinolone in Acute Otitis Externa (AOE)
NCT01447017	PHASE2	COMPLETED	A Study of DPK-060 to Investigate Clinical Safety and Efficacy in Patients With Acute External Otitis
NCT01584271	PHASE2	UNKNOWN	Study of Ear Comfort Ear Drops to Treat AOE Cases Compared to DexOtic & Otidin(R)
NCT02918773	Not specified	COMPLETED	Pediatric Emergency Department Smartphone Otoscope Study (PED-Oto)

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
CIPROFLOXACIN	4	3
DEXAMETHASONE	4	2
FINAFLOXACIN	4	2
VEHICLE	0	2