Acute respiratory failure

Summary

Acute respiratory failure (MONDO:0001208) is a disease and 284 clinical trials. Top therapeutic interventions include dexmedetomidine, etomidate, and nitrous acid. A subtype of acute disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 284

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	acute respiratory failure
Mondo ID	MONDO:0001208
ICD-10-CM	J96.0
ICD-11	875272781
NCIT	C27043
SNOMED CT	65710008
UMLS	C0264490
MedGen	75540
Is cancer (heuristic)	no

Also known as: acute respiratory failure · respiratory failure, acute

Disease family

This is a subtype of acute disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › acute disease › acute respiratory failure

Related subtypes (118): encephalopathy, acute, infection-induced, seminal vesicle acute gonorrhea, acute diarrhea, acute hydrops keratoconus, acute pericementitis, purulent acute otitis media, acute otitis externa, acute eustachian salpingitis, acute cervicitis, acute gonococcal epididymo-orchitis, acute salpingitis, acute conjunctivitis, acute laryngopharyngitis, acute orbital inflammation, acute dacryocystitis, acute sphenoidal sinusitis, acute proliferative glomerulonephritis, acute cystitis, acute tympanitis, acute closed-angle glaucoma, acute gonococcal prostatitis, acute poststreptococcal glomerulonephritis, acute diffuse glomerulonephritis, acute retrobulbar neuritis, acute frontal sinusitis, acute cholangitis, acute thyroiditis, acute maxillary sinusitis, acute kidney injury, acute transudative otitis media, acute myocarditis, subacute glomerulonephritis, acute pyelonephritis, acute urate nephropathy, acute stress disorder, acute inflammation of lacrimal passage, acute endometritis, acute cor pulmonale, acute intestinal ischemia, subacute delirium, acute laryngitis, acute myocardial infarction, acute ethmoiditis, acute dacryoadenitis, acute female pelvic peritonitis, acute quadriplegic myopathy, severe acute respiratory syndrome, acute hypotension, acute coronary syndrome, acute chest syndrome, acute pancreatitis, acute retinal necrosis syndrome, subacute bacterial endocarditis, necrotizing encephalomyelopathy, subacute, of Leigh, adult, acute intermittent porphyria, leukemia, acute myelocytic, with polyposis coli and colon cancer, surfactant metabolism dysfunction, pulmonary, 1, myoglobinuria, acute recurrent, autosomal recessive, acute leukemia, acute insulin response, alcohol sensitivity, acute, leukemia, acute lymphocytic, susceptibility to, 1, leukemia, acute lymphocytic, susceptibility to, 2, acute infantile liver failure-cerebellar ataxia-peripheral sensory motor neuropathy syndrome, acute transverse myelitis, subacute cutaneous lupus erythematosus, acute lung injury, subacute inflammatory demyelinating polyneuropathy, Marburg acute multiple sclerosis, acute pure sensory neuropathy, autoimmune autonomic ganglionopathy, acute sensory ataxic neuropathy, acute fatty liver of pregnancy, acute neonatal citrullinemia type I, acute endophthalmitis, acute zonal occult outer retinopathy, acute annular outer retinopathy, poliomyelitis, acute generalized exanthematous pustulosis, acute opioid poisoning, acute encephalopathy with biphasic seizures and late reduced diffusion, acute tricyclic antidepressant poisoning, acute poisoning by drugs with membrane-stabilizing effect, recurrent acute pancreatitis, bilateral acute depigmentation of the iris, idiopathic acute eosinophilic pneumonia, acute ackee fruit intoxication, acute interstitial pneumonia, acute liver failure, acute adrenal insufficiency, encephalitis, acute inflammatory demyelinating polyradiculoneuropathy, acute motor and sensory axonal neuropathy, acute motor axonal neuropathy, acute graft versus host disease, acute pharyngitis, sudden hearing loss disorder, acute bronchiolitis, acute tonsillitis, acute rheumatic heart disease, acute cholinergic dysautonomia, acute mountain sickness, acute lymphoblastic leukemia congenital sporadic aniridia, acute lichenoid pityriasis, leukoencephalopathy, acute reversible, with increased urinary alpha-ketoglutarate, acute radiation syndrome, acute bilirubin encephalopathy, acute mast cell leukemia, subacute bursitis, acute papillary necrosis, acute posterior multifocal placoid pigment epitheliopathy, acute idiopathic urticaria, acute macular neuroretinopathy, acute flaccid myelitis, acute hepatitis B virus infection, acute hepatitis C virus infection, acute fibrinous and organizing pneumonia, acute transplant rejection

Subtypes (3): neonatal respiratory failure, acute respiratory distress syndrome, pulmonary edema

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 284.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	244
PHASE2	11
PHASE3	10
PHASE4	9
PHASE2/PHASE3	6
PHASE1/PHASE2	3
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06881927	PHASE4	NOT_YET_RECRUITING	Eduction in ImmunoSuppressive Regimen Among Kidney Transplant Recipients Patients Admitted to the Intensive Care Unit for Septic Shock and/or Acute Respiratory Failure
NCT00600639	PHASE4	TERMINATED	Non-Invasive Mechanical Ventilation in Elderly Patients
NCT00925860	PHASE4	COMPLETED	Non-Positive Pressure Ventilation in Hypoxemic Patients
NCT01280019	PHASE4	UNKNOWN	FRC Guided Therapy in Acute Respiratory Failure
NCT01572337	PHASE4	COMPLETED	Early Non-invasive Ventilation Outside the Intensive Care Unit
NCT02958150	PHASE4	UNKNOWN	Dexmedetomidine Versus Standard Clinical Practice During Non Invasive Mechanical Ventilation
NCT03026777	PHASE4	COMPLETED	Preventing Cardiovascular collaPse With Administration of Fluid Resuscitation Before Endotracheal Intubation
NCT03787732	PHASE4	COMPLETED	Preventing Cardiovascular Collapse With Administration of Fluid Resuscitation During Induction and Intubation
NCT05277896	PHASE4	COMPLETED	Randomized Trial of Sedative Choice for Intubation
NCT06815679	PHASE2/PHASE3	NOT_YET_RECRUITING	Physiological Effects of Nebulized Salbutamol in Acute Respiratory Failure Patients on HFNC
NCT00000562	PHASE3	COMPLETED	Extracorporeal Support for Respiratory Insufficiency (ECMO)
NCT00248443	PHASE3	COMPLETED	Réa-MiniMax: Severe Acute Respiratory Failure in Hematology and Cancer Patients Without Bronchoalveolar Lavage
NCT00252616	PHASE2/PHASE3	COMPLETED	Timing of Target Enteral Feeding in the Mechanically Ventilated Patient
NCT01206166	PHASE3	TERMINATED	Trial of Supplemental Parenteral Nutrition in Under and Over Weight Critically Ill Patients (TOP-UP)
NCT01242150	PHASE3	COMPLETED	Noninvasive Continuous Positive Airway Pressure (NCPAP) in Children
NCT01320384	PHASE2/PHASE3	COMPLETED	Clinical Effect of the Association of Noninvasive Ventilation and High Flow Nasal Oxygen Therapy in Resuscitation of Patients With Acute Lung Injury (FLORALI Study)
NCT01580956	PHASE3	COMPLETED	VARIABLE-PSV Study
NCT01713309	PHASE2/PHASE3	COMPLETED	Heparin Binding Protein in Patients With Acute Respiratory Failure Treated With GCSF (Filgrastim)
NCT01966861	PHASE3	UNKNOWN	Weaning From Mechanical Ventilation Guided by Lung Ultrasound (Brazilian WEANLUS)
NCT02421614	PHASE2/PHASE3	COMPLETED	Enteral Feeding Composition and Acute Respiratory Failure
NCT02424773	PHASE3	COMPLETED	Oxygen Therapy During Acute Respiratory Failure in Immuno-compromised Patients
NCT04193878	PHASE3	TERMINATED	ARrest RESpiraTory Failure From PNEUMONIA
NCT04327505	PHASE2/PHASE3	TERMINATED	Safety and Efficacy of Hyperbaric Oxygen for ARDS in Patients With COVID-19
NCT04680884	PHASE3	UNKNOWN	Empirical Steroids and/or Antifungals in Immunocompromised Patients With Acute Respiratory Failure From Undetermined Etiology: a Multicenter Double-blind Randomized Controlled Trial
NCT04706507	PHASE3	TERMINATED	Ganciclovir to Prevent Reactivation of Cytomegalovirus in Patients With Acute Respiratory Failure and Sepsis
NCT05540834	PHASE2	RECRUITING	Viscoelastic Testing Guided Tissue Plasminogen Activator Treatment in Acute Respiratory Failure
NCT06319274	PHASE2	RECRUITING	Infusion of Prostacyclin vs Placebo for 72-hours in Mechanically Ventilated Patients With Acute Respiratory Failure
NCT07293078	PHASE1/PHASE2	NOT_YET_RECRUITING	Point-of-Care AI Assistance and Critical Care Outcomes: A Randomized Trial
NCT07357935	PHASE1/PHASE2	NOT_YET_RECRUITING	Early Inflammatory-Immune Stratification and Precision Glucocorticoid Intervention in Acute Respiratory Failure Induced by Community-Acquired Pneumonia
NCT00167622	PHASE2	COMPLETED	Early Mechanical Ventilation for Guillain Barré Syndrome
NCT00871624	PHASE2	COMPLETED	Efficacy and Safety of Dexmedetomidine During Non-Invasive Positive Pressure Ventilation
NCT01606852	PHASE1/PHASE2	COMPLETED	Testing the Feasibility of Patient Controlled Sedation for Ventilated ICU Patients
NCT03021902	PHASE2	COMPLETED	Nutrition and Exercise in Critical Illness
NCT04315558	PHASE2	COMPLETED	Revefenacin in Acute Respiratory Insufficiency in COPD
NCT04358133	PHASE2	COMPLETED	Low Dose Morphine to Relieve Dyspnea in Acute Respiratory Failure (OPIDYS)
NCT04397497	PHASE2	UNKNOWN	Mavrilimumab in Severe COVID-19 Pneumonia and Hyper-inflammation (COMBAT-19)
NCT04401527	PHASE2	WITHDRAWN	Treatment of Lung Injury From COVID-19 Infection With Intravenous Sodium Nitrite
NCT04611425	PHASE2	COMPLETED	REmimazolam Infusion in the Context of Hypnotic Shortage in the Critical Care Unit During the Pandemic of COVID-19: REHSCU Study
NCT05092152	PHASE2	COMPLETED	Propofol Versus Ketamine for Rapid Sequence Intubation in Critically Ill Patients
NCT03621475	PHASE1	COMPLETED	Novel Arm Restraint in the Intensive Care Unit

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
DEXMEDETOMIDINE	4	3
ETOMIDATE	4	2
NITROUS ACID	4	2
OXYGEN	4	2
THIAMINE ION	4	2
ALTEPLASE	4	1
ARFORMOTEROL	4	1
BIVALIRUDIN	4	1
ESKETAMINE	4	1
FORMOTEROL	4	1
ILOPROST	4	1
IPRATROPIUM BROMIDE	4	1
NICARDIPINE	4	1
REMIMAZOLAM	4	1
SODIUM NITROPRUSSIDE	4	1
MAVRILIMUMAB	2	1
CHEMBL1237108	0	1
CHEMBL1908368	0	1
S-ETOMIDATE	-1	2