Acute transverse myelitis

Summary

Acute transverse myelitis (MONDO:0015342) is a disease and 1 clinical trial. A subtype of myelitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: 1-9 / 100 000 (United States) [Orphanet-validated]
• Phenotypes (HPO): 53
• Clinical trials: 1

Clinical features

Epidemiology

Prevalence records

3 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Annual incidence	1-9 / 100 000	4.72	Worldwide	Validated
Annual incidence	1-9 / 100 000	8.6	United States	Validated
Point prevalence	1-9 / 100 000	7.9	United States	Validated

Signs & symptoms

Clinical features (HPO)

53 HPO clinical features (Orphanet curated; top 50 by frequency):

HPO ID	Term	Frequency
HP:0001324	Muscle weakness	Frequent (30-79%)
HP:0002071	Abnormality of extrapyramidal motor function	Frequent (30-79%)
HP:0002922	Increased CSF protein concentration	Frequent (30-79%)
HP:0003474	Somatic sensory dysfunction	Frequent (30-79%)
HP:0012229	CSF pleocytosis	Frequent (30-79%)
HP:0012332	Abnormal autonomic nervous system physiology	Frequent (30-79%)
HP:5000013	Anti-GFAP antibody	Frequent (30-79%)
HP:0000016	Urinary retention	Occasional (5-29%)
HP:0000020	Urinary incontinence	Occasional (5-29%)
HP:0000822	Hypertension	Occasional (5-29%)
HP:0001257	Spasticity	Occasional (5-29%)
HP:0001278	Orthostatic hypotension	Occasional (5-29%)
HP:0001287	Meningitis	Occasional (5-29%)
HP:0001288	Gait disturbance	Occasional (5-29%)
HP:0001347	Hyperreflexia	Occasional (5-29%)
HP:0001945	Fever	Occasional (5-29%)
HP:0002019	Constipation	Occasional (5-29%)
HP:0002138	Subarachnoid hemorrhage	Occasional (5-29%)
HP:0002385	Paraparesis	Occasional (5-29%)
HP:0002493	Upper motor neuron dysfunction	Occasional (5-29%)
HP:0002495	Impaired vibratory sensation	Occasional (5-29%)
HP:0002578	Gastroparesis	Occasional (5-29%)
HP:0002590	Paralytic ileus	Occasional (5-29%)
HP:0002721	Immunodeficiency	Occasional (5-29%)
HP:0002725	Systemic lupus erythematosus	Occasional (5-29%)
HP:0002839	Urinary bladder sphincter dysfunction	Occasional (5-29%)
HP:0002960	Autoimmunity	Occasional (5-29%)
HP:0003401	Paresthesia	Occasional (5-29%)
HP:0003418	Back pain	Occasional (5-29%)
HP:0003484	Upper limb muscle weakness	Occasional (5-29%)
HP:0003487	Babinski sign	Occasional (5-29%)
HP:0004370	Abnormality of temperature regulation	Occasional (5-29%)
HP:0005341	Autonomic bladder dysfunction	Occasional (5-29%)
HP:0007305	CNS demyelination	Occasional (5-29%)
HP:0009053	Distal lower limb muscle weakness	Occasional (5-29%)
HP:0010547	Muscle flaccidity	Occasional (5-29%)
HP:0010550	Paraplegia	Occasional (5-29%)
HP:0010831	Impaired proprioception	Occasional (5-29%)
HP:0010835	Dissociated sensory loss	Occasional (5-29%)
HP:0011967	Decreased circulating copper concentration	Occasional (5-29%)
HP:0011972	Hypoglycorrhachia	Occasional (5-29%)
HP:0012378	Fatigue	Occasional (5-29%)
HP:0012534	Dysesthesia	Occasional (5-29%)
HP:0025615	Abscess	Occasional (5-29%)
HP:0031179	Nuchal rigidity	Occasional (5-29%)
HP:0031691	Severe viral infection	Occasional (5-29%)
HP:0031700	Invasive parasitic infection	Occasional (5-29%)
HP:0031845	Abnormal libido	Occasional (5-29%)
HP:0032271	Extrapulmonary tuberculosis	Occasional (5-29%)
HP:0032283	Disseminated nontuberculous mycobacterial infection	Occasional (5-29%)

Identifiers

Disease identifiers

Field	Value
Canonical name	acute transverse myelitis
Mondo ID	MONDO:0015342
MeSH	D009188
Orphanet	139417
NCIT	C128378
SNOMED CT	47000000
UMLS	C0270627
MedGen	82847
GARD	0019913
Is cancer (heuristic)	no

Disease family

This is a subtype of myelitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › spinal cord disorder › myelitis › acute transverse myelitis

Related subtypes (3): poliomyelitis, transverse myelitis, acute flaccid myelitis

Subtypes (2): idiopathic acute transverse myelitis, acute transverse myelitis with anti-MOG antibodies

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 1.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00004645	PHASE3	UNKNOWN	Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone