Adenoid hypertrophy
diseaseOn this page
Also known as adenoidal hypertrophyenlarged adenoids
Summary
Adenoid hypertrophy (MONDO:0000740) is a disease and 21 clinical trials. Top therapeutic interventions include dextromethorphan, oxymetazoline, and mometasone furoate. A subtype of upper respiratory tract disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 21
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | adenoid hypertrophy |
| Mondo ID | MONDO:0000740 |
| DOID | DOID:0060311 |
| ICD-11 | 2068842254 |
| SNOMED CT | 111591002 |
| UMLS | C0455938 |
| MedGen | 628857 |
| MedDRA | 10001229 |
| Anatomy (UBERON) | UBERON:0001734 |
| Is cancer (heuristic) | no |
Also known as: adenoidal hypertrophy · enlarged adenoids
Disease family
This is a subtype of upper respiratory tract disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › respiratory system disorder › upper respiratory tract disorder › adenoid hypertrophy
Related subtypes (9): uvulitis, tonsillitis, acute laryngopharyngitis, nasal cavity disorder, pharyngitis, tracheal disorder, laryngeal disorder, nasopharyngeal disorder, epiglottitis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 21.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 16 |
| PHASE4 | 4 |
| PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT02205580 | PHASE4 | UNKNOWN | Continuous Intravenous Sufentanil Infusion for Postoperative Pain Management Following Tonsillectomy or Adeno-tonsillectomy in Children |
| NCT02559440 | PHASE4 | COMPLETED | Mometasone Furoate and Oxymetazoline in the Treatment of Adenoid Hypertrophy |
| NCT03243565 | PHASE4 | UNKNOWN | Effect of OM-85 on Respiratory Tract Infections and Adenoid Tissue in Children With Adenoid Hypertrophy |
| NCT03902314 | PHASE4 | COMPLETED | Lidocaine Infusion for Pain Relief in Children Scheduled for Tonsillectomy and Adenoidectomy |
| NCT03714919 | PHASE2 | COMPLETED | A Pilot Study: a Non-opioid Technique for Postoperative Adenoidectomy Pain Relief in Pediatric Patients |
| NCT06266429 | Not specified | ACTIVE_NOT_RECRUITING | Metabolomic Profiling of Racial Disparity |
| NCT06674720 | Not specified | NOT_YET_RECRUITING | It is Accepted That Adenoid Hypertrophy is Related to Otitis Media With Effusion Incidence. Better Understanding of the Correlation Between the Relative Size of AH and the Incidence of Persistent OME May Provide Evidence to Support a More Standardized Approach to the Diagnosis and Treatment of OME. |
| NCT07094581 | Not specified | RECRUITING | Evaluation of the Effect of Adenoid Hypertrophy on the Masseter Muscle in Children: A Comparative Ultrasonographic Study |
| NCT07399041 | Not specified | NOT_YET_RECRUITING | Evaluation of the Effects of Adenoidectomy and Adenotonsillectomy on Voice in Children |
| NCT07552545 | Not specified | NOT_YET_RECRUITING | Full-wrap Versus Conventional Suspension for Reducing Soft Palate Injury Rate |
| NCT03677453 | Not specified | COMPLETED | Interactive Perioperative Teaching Platform (IPTP) |
| NCT03890692 | Not specified | UNKNOWN | Methods of Assessment of Adenoid Size |
| NCT04152746 | Not specified | COMPLETED | Periostin Levels in Children With Adenoid Hypertrophy |
| NCT04256590 | Not specified | COMPLETED | Tongue Depressor-related Tongue Swelling |
| NCT04302337 | Not specified | WITHDRAWN | Conventional Curettage Adenoidectomy vs Curettage Adenoidectomy With Transoral Endoscopic Residue Ablation in Children |
| NCT04431128 | Not specified | COMPLETED | Adenoid Hypertrophy, Respiratory Complications and Correlation With Infant Feeding Position |
| NCT04646525 | Not specified | UNKNOWN | The Relationship Between Covid-19 Infection in Pediatric Patients and Secondary Lymphoid Organs |
| NCT05291312 | Not specified | UNKNOWN | EACA VS CCA in Postoperative Evaluation of Middle Ear Pressure |
| NCT05402267 | Not specified | UNKNOWN | The Effects of Exosomes in Otitis Media With Effusion |
| NCT06169384 | Not specified | UNKNOWN | Endoscopic Partial Adenoidectomy Versus Total Adenoidectomy Regarding Rate of Recurrence and Relief of Symptoms |
| NCT06841432 | Not specified | COMPLETED | Coblation Versus Suction Diathermy in Pediatric Adenoidectomy |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| DEXTROMETHORPHAN | 4 | 3 |
| OXYMETAZOLINE | 4 | 3 |
| MOMETASONE FUROATE | 4 | 1 |
| SODIUM CHLORIDE | 4 | 1 |