Adenoma
diseaseOn this page
Also known as acinar cell adenomaacinar cell adenoma (morphologic abnormality)adenoma, benign
Summary
Adenoma (MONDO:0004972) is a cancer (an umbrella term covering 31 Mondo subtypes) and 103 clinical trials. Top therapeutic interventions include indocyanine green acid form, cabergoline, and calcium carbonate. A subtype of epithelial neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Umbrella term: 31 Mondo subtypes
- Clinical trials: 103
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | adenoma |
| Mondo ID | MONDO:0004972 |
| EFO | EFO:0000232 |
| MeSH | D000236 |
| DOID | DOID:657 |
| NCIT | C2855 |
| SNOMED CT | 443416007 |
| UMLS | C0001430 |
| MedGen | 125 |
| Anatomy (UBERON) | UBERON:0002530 |
| Is cancer (heuristic) | yes |
Also known as: acinar cell adenoma · acinar cell adenoma (morphologic abnormality) · adenoma · adenoma, benign
Disease family
An umbrella term covering 31 Mondo subtypes.
Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › epithelial neoplasm › adenoma
Related subtypes (23): ovarian epithelial tumor, myoepithelial tumor, endometrioid tumor, squamous cell neoplasm, pancreatic delta cell neuroendocrine tumor, thyroid hyalinizing trabecular adenoma, Wolffian adnexal tumor, carcinoma, cystic, mucinous, and serous neoplasm, thymic epithelial neoplasm, epithelial tumor of anal canal, growth hormone-producing pituitary gland neoplasm, basal cell neoplasm, sympathetic paraganglioma, papillary epithelial neoplasm, epithelial skin neoplasm, glandular cell neoplasm, intraepithelial neoplasia, epithelial neoplasm of rectum, epithelial tumor of colon, mesonephric neoplasm, benign epithelial neoplasm, transitional cell neoplasm
Subtypes (31): villous adenoma, breast adenoma, minor vestibular glands adenoma, cystadenoma, sebaceous adenoma, renal adenoma, prostatic adenoma, papillary adenoma, Bartholin gland adenoma, mixed cell adenoma, lung adenoma, middle ear adenoma, oncocytic adenoma, clear cell adenoma, lipoadenoma, water-clear cell adenoma, vaginal adenoma, microcystic adenoma, rete testis adenoma, adrenal cortex adenoma, follicular thyroid adenoma, ovarian adenoma benign, digestive system adenoma, mixed somatotroph-lactotroph pituitary gland adenoma, pituitary gland adenoma, parathyroid gland adenoma, hepatocellular adenoma, adenoma of pancreas, sweat gland adenoma, tubular adenoma, tubulovillous adenoma
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
1 approved, 1 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.
| Drug | Development status |
|---|---|
| Corticorelin Ovine Triflutate | Approved (phase 4) |
| Fentanyl | Phase 3 (in late-stage trials) |
Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Bevacizumab, Pasireotide, Tamoxifen, Temsirolimus.
Clinical trials & evidence
Clinical trials
Clinical trials: 103.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 93 |
| PHASE3 | 3 |
| PHASE4 | 2 |
| PHASE2/PHASE3 | 2 |
| PHASE1 | 2 |
| PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT02032784 | PHASE4 | TERMINATED | Prophylactic Octreotide to Prevent Post Duodenal EMR and Ampullectomy Bleeding |
| NCT06169735 | PHASE4 | TERMINATED | Does Fluorescence With or Without Indocyanine Green Improve Parathyroid Identification and Preservation |
| NCT02288962 | PHASE3 | ACTIVE_NOT_RECRUITING | Dopamine Agonist Treatment of Non-functioning Pituitary Adenomas |
| NCT00153816 | PHASE2/PHASE3 | COMPLETED | Vitamin D/Calcium Polyp Prevention Study |
| NCT00272324 | PHASE2/PHASE3 | COMPLETED | Aspirin/Folate Prevention of Large Bowel Polyps |
| NCT00339625 | PHASE3 | COMPLETED | Polyp Prevention Trial |
| NCT01370928 | PHASE3 | COMPLETED | Colonoscopy Screening Using a Novel Slim Colonoscope - a Randomized Controlled Trial |
| NCT00018551 | PHASE2 | COMPLETED | Chemoprevention With Folic Acid |
| NCT06398418 | PHASE1 | RECRUITING | R-5780-01 In Combination With PD-1 Checkpoint Inhibitors (Checkpoint Protein on Immune Cells Called T Cells) in Patients With Solid Tumors |
| NCT07582003 | PHASE1 | NOT_YET_RECRUITING | A Phase I Trial of S-Adenosylmethionine (SAMe) for Chemoprevention of Colorectal Adenomas |
| NCT00119912 | Not specified | ACTIVE_NOT_RECRUITING | NORCCAP: Norwegian Colorectal Cancer Prevention Trial |
| NCT04648462 | Not specified | RECRUITING | Proton Therapy Research Infrastructure- ProTRAIT- Neuro-oncology |
| NCT05144152 | Not specified | RECRUITING | Diagnostic Accuracy of M3 in Predicting Colorectal Advanced Adenoma Recurrence (M3-AA) |
| NCT05362344 | Not specified | ACTIVE_NOT_RECRUITING | Colorectal Cancer Screening in Cystic Fibrosis |
| NCT05551052 | Not specified | ACTIVE_NOT_RECRUITING | CRC Detection Reliable Assessment With Blood |
| NCT05592886 | Not specified | RECRUITING | A Novel Oral Synbiotic Formula in Reducing Advanced Adenoma Recurrence and Colorectal Neoplasia-related Bacterial Gene Markers |
| NCT05912764 | Not specified | RECRUITING | Evaluation of Early Home Return in Patients With Enucleation of Prostate Adenoma |
| NCT06220617 | Not specified | RECRUITING | Multi-omics Study for Early Detection of Colorectal Cancer (MOED-CRC) |
| NCT06515977 | Not specified | NOT_YET_RECRUITING | Texture and Colour Enhancement Imaging in Improving Detection and Miss Rate of Premalignant Lesions |
| NCT07090291 | Not specified | RECRUITING | China Colorectal Cancer Screening Trial 1 (C-Cost1) |
| NCT07090304 | Not specified | NOT_YET_RECRUITING | China Colorectal Cancer Screening Trial 2 (C-Cost2) |
| NCT07142902 | Not specified | NOT_YET_RECRUITING | Gastroduodenal Full Thickness Resection Device Registry - gdFTRD® Registry |
| NCT07198945 | Not specified | NOT_YET_RECRUITING | Six Versus Twelve Month Index Follow-up After Large Colon Polyp Resection |
| NCT07307547 | Not specified | NOT_YET_RECRUITING | Efficacy of AI-Assisted Colonoscopy for Screening Colorectal Neoplasia (AI-COLOSCREEN) |
| NCT07470827 | Not specified | ACTIVE_NOT_RECRUITING | Evaluation of ‘WAYMED Endo CL CS’ for Automated Detection and Diagnosis of Colorectal Adenoma and Non-Adenoma Lesions |
| NCT00245492 | Not specified | COMPLETED | Chromocolonoscopy for the Detection of Flat Adenomas in Routine Colorectal Cancer Screening. |
| NCT00279357 | Not specified | UNKNOWN | Randomised Trial of NBI for Adenoma Detection |
| NCT00518349 | Not specified | COMPLETED | Colonoscope Passive Bending Function |
| NCT00633620 | Not specified | COMPLETED | Narrow Band Versus Conventional Endoscopic Imaging for Screening Colonoscopy |
| NCT00859625 | Not specified | COMPLETED | The Impact of Active Nurse Participation on Adenoma Detection During Routine Colonoscopy |
| NCT01043523 | Not specified | COMPLETED | Liver MRI With Primovist/Eovist in Pediatric Subjects Who Are Suspected or Have Focal Liver Lesions. |
| NCT01190501 | Not specified | COMPLETED | Arterial Stiffness Index as a Predictor of Surgically Correctable Primary Aldosteronism |
| NCT01211132 | Not specified | UNKNOWN | Cap Assisted Colonoscopy for the Detection of Colon Polyps |
| NCT01366079 | Not specified | COMPLETED | Dynamic Position Change in Colonic Adenoma Detection |
| NCT01485133 | Not specified | COMPLETED | Water Method Colonoscopy in Patients With Prior Surgery |
| NCT01546220 | Not specified | WITHDRAWN | Water Method in Elder Patients With Unsedated Colonoscopy |
| NCT01546246 | Not specified | WITHDRAWN | Water Method in Patients With Incomplete Colonoscopy |
| NCT01546259 | Not specified | WITHDRAWN | Water Method in Low-body Mass Index (BMI) Female Patients With Unsedated Colonoscopy |
| NCT01552200 | Not specified | COMPLETED | Performance Evaluation of the NaviAid™ G-Eye System |
| NCT01584817 | Not specified | COMPLETED | A Repeated Instruction by Telephone on the Day Before Colonoscopy to Patients Undergoing Colonoscopy |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| INDOCYANINE GREEN ACID FORM | 4 | 2 |
| CABERGOLINE | 4 | 1 |
| CALCIUM CARBONATE | 4 | 1 |
| FOLIC ACID | 4 | 1 |
| OCTREOTIDE | 4 | 1 |
| ADEMETIONINE | 3 | 1 |
| CHEMBL3350037 | 0 | 1 |
| CHEMBL4593105 | 0 | 1 |
| CHEMBL5192470 | 0 | 1 |
| CHEMBL1235831 | 0 | 1 |