Adenosquamous carcinoma

Summary

Adenosquamous carcinoma (MONDO:0006074) is a cancer (an umbrella term covering 15 Mondo subtypes) and 8 clinical trials. Top therapeutic interventions include fludarabine phosphate. A subtype of squamous cell carcinoma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Umbrella term: 15 Mondo subtypes
• Clinical trials: 8

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	adenosquamous carcinoma
Mondo ID	MONDO:0006074
EFO	EFO:1000073
MeSH	D018196
DOID	DOID:4830
ICD-11	1793155313
NCIT	C3727
SNOMED CT	403902008
UMLS	C0206623
MedGen	104901
Is cancer (heuristic)	yes

Also known as: adenosquamous carcinoma · adenosquamous carcinoma (morphologic abnormality) · carcinoma, adenosquamous, malignant · mixed adenocarcinoma and epidermoid carcinoma · mixed adenocarcinoma and epidermoid cell carcinoma · mixed adenocarcinoma and squamous carcinoma · mixed adenocarcinoma and squamous cell carcinoma

Disease family

This is a subtype of squamous cell carcinoma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › epithelial neoplasm › squamous cell neoplasm › squamous cell carcinoma › adenosquamous carcinoma

Related subtypes (38): bone squamous cell carcinoma, prostate squamous cell carcinoma, trachea squamous cell carcinoma, scrotum squamous cell carcinoma, skin squamous cell carcinoma, bladder squamous cell carcinoma, urethra squamous cell carcinoma, papillary squamous carcinoma, basaloid squamous cell carcinoma, pseudoglandular squamous cell carcinoma, thymus squamous cell carcinoma, ovarian squamous cell carcinoma, renal pelvis squamous cell carcinoma, ureter squamous cell carcinoma, fallopian tube squamous cell carcinoma, squamous carcinoma in situ, keratinizing squamous cell carcinoma, squamous cell lung carcinoma, esophageal squamous cell carcinoma, squamous cell breast carcinoma, cervical squamous cell carcinoma, colorectal squamous cell carcinoma, endometrial squamous cell carcinoma, gallbladder squamous cell carcinoma, gastric squamous cell carcinoma, thyroid gland squamous cell carcinoma, vaginal squamous cell carcinoma, head and neck squamous cell carcinoma, squamous cell carcinoma of the corpus uteri, squamous cell carcinoma of penis, squamous cell carcinoma of the small intestine, squamous cell carcinoma of pancreas, squamous cell carcinoma of liver and intrahepatic biliary tract, human papillomavirus-related squamous cell carcinoma, sarcomatoid squamous cell carcinoma, vulvar squamous cell carcinoma, metastatic squamous cell carcinoma, pure squamous carcinoma of the urothelial tract

Subtypes (15): adenosquamous breast carcinoma, esophageal adenosquamous carcinoma, thymic adenosquamous carcinoma, Bartholin gland adenosquamous carcinoma, endometrial adenosquamous carcinoma, adenosquamous prostate carcinoma, adenosquamous lung carcinoma, pancreatic adenosquamous carcinoma, gastric adenosquamous carcinoma, cervical adenosquamous carcinoma, colorectal adenosquamous carcinoma, gallbladder adenosquamous carcinoma, salivary gland adenosquamous carcinoma, liver adenosquamous carcinoma, skin adenosquamous carcinoma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 8.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE3	3
PHASE2	2
Not specified	2
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT05581121	PHASE3	RECRUITING	PARa-aOrtic LymphAdenectomy in Locally Advanced Cervical Cancer
NCT01363466	PHASE3	TERMINATED	Evaluation of Hysterectomy After Chemoradiation Therapy for Stage IB2/II Cervical Cancer
NCT01365156	PHASE3	COMPLETED	Extraperitoneal Para-aortic Lymph Node Dissection (EPLND) for Cervix
NCT02133196	PHASE2	RECRUITING	T Cell Receptor Immunotherapy for Patients With Metastatic Non-Small Cell Lung Cancer
NCT05988918	PHASE2	ACTIVE_NOT_RECRUITING	Multicenter Trial of ESK981 in Patients With Select Solid Tumors
NCT03215810	PHASE1	COMPLETED	Nivolumab and Tumor Infiltrating Lymphocytes (TIL) in Advanced Non-Small Cell Lung Cancer
NCT00895349	Not specified	COMPLETED	Impact of Positron Emission Tomography (PET) Imaging in Women With Locally Advanced Cervical Cancer (PET LACE Trial)
NCT05337163	Not specified	COMPLETED	A Multicenter Clinical Trial of Sputum DNA Testing for Lung Cancer in China

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
FLUDARABINE PHOSPHATE	4	2