Adiposis dolorosa
diseaseOn this page
Also known as Adiposalgiaadipose tissue rheumatismDercum diseaseDercum's Diseaselipomatosis dolorosaNeurolipomatosis
Summary
Adiposis dolorosa (MONDO:0007070) is a disease and 5 clinical trials. Top therapeutic interventions include utenpanium chloride. A subtype of integumentary system benign neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: Unknown (Worldwide)
- Phenotypes (HPO): 40
- Clinical trials: 5
Clinical features
Signs & symptoms
Clinical features (HPO)
40 HPO clinical features (Orphanet curated; top 40 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0000709 | Psychosis | Very frequent (80-99%) |
| HP:0000716 | Depression | Very frequent (80-99%) |
| HP:0000739 | Anxiety | Very frequent (80-99%) |
| HP:0001482 | Subcutaneous nodule | Very frequent (80-99%) |
| HP:0001513 | Obesity | Very frequent (80-99%) |
| HP:0002829 | Arthralgia | Very frequent (80-99%) |
| HP:0012378 | Fatigue | Very frequent (80-99%) |
| HP:0001031 | Subcutaneous lipoma | Frequent (30-79%) |
| HP:0002027 | Abdominal pain | Frequent (30-79%) |
| HP:0002215 | Sparse axillary hair | Frequent (30-79%) |
| HP:0002225 | Sparse pubic hair | Frequent (30-79%) |
| HP:0003119 | Abnormal circulating lipid concentration | Frequent (30-79%) |
| HP:0003270 | Abdominal distention | Frequent (30-79%) |
| HP:0003565 | Elevated erythrocyte sedimentation rate | Frequent (30-79%) |
| HP:0007596 | Painful subcutaneous lipomas | Frequent (30-79%) |
| HP:0011227 | Elevated circulating C-reactive protein concentration | Frequent (30-79%) |
| HP:0012532 | Chronic pain | Frequent (30-79%) |
| HP:0025406 | Asthenia | Frequent (30-79%) |
| HP:0025502 | Overweight | Frequent (30-79%) |
| HP:0031905 | Increased total hemolytic complement activity | Frequent (30-79%) |
| HP:0000217 | Xerostomia | Occasional (5-29%) |
| HP:0000819 | Diabetes mellitus | Occasional (5-29%) |
| HP:0000821 | Hypothyroidism | Occasional (5-29%) |
| HP:0000822 | Hypertension | Occasional (5-29%) |
| HP:0000958 | Dry skin | Occasional (5-29%) |
| HP:0000978 | Bruising susceptibility | Occasional (5-29%) |
| HP:0001250 | Seizure | Occasional (5-29%) |
| HP:0001369 | Arthritis | Occasional (5-29%) |
| HP:0001581 | Recurrent skin infections | Occasional (5-29%) |
| HP:0002014 | Diarrhea | Occasional (5-29%) |
| HP:0002019 | Constipation | Occasional (5-29%) |
| HP:0002315 | Headache | Occasional (5-29%) |
| HP:0002354 | Memory impairment | Occasional (5-29%) |
| HP:0002360 | Sleep abnormality | Occasional (5-29%) |
| HP:0002376 | Developmental regression | Occasional (5-29%) |
| HP:0002960 | Autoimmunity | Occasional (5-29%) |
| HP:0003401 | Paresthesia | Occasional (5-29%) |
| HP:0009830 | Peripheral neuropathy | Occasional (5-29%) |
| HP:0034265 | Mastalgia | Occasional (5-29%) |
| HP:0100585 | Telangiectasia of the skin | Occasional (5-29%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | adiposis dolorosa |
| Mondo ID | MONDO:0007070 |
| EFO | EFO:1000667 |
| MeSH | D000274 |
| OMIM | 103200 |
| Orphanet | 36397 |
| DOID | DOID:3928 |
| NCIT | C84540 |
| SNOMED CT | 71404003 |
| UMLS | C0001529 |
| MedGen | 1757 |
| GARD | 0005750 |
| MedDRA | 10001294 |
| NORD | 1046 |
| Is cancer (heuristic) | no |
Also known as: Adiposalgia · adipose tissue rheumatism · adiposis dolorosa · Dercum disease · Dercum’s Disease · Dercum’s disease · lipomatosis dolorosa · Neurolipomatosis
Disease family
Classification path: disease › human disease › disease by body system or component › integumentary system disorder › integumentary system benign neoplasm › adiposis dolorosa
Related subtypes (7): Bartholin gland benign neoplasm, hemangioma of subcutaneous tissue, multiple symmetric lipomatosis, familial multiple lipomatosis, intraductal breast papilloma, adenoma of nipple, benign neoplasm of skin
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
No approved or late-stage (phase ≥3) drug is indicated for this disease; the following are in earlier-phase trials only.
Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Sodium Chloride.
Clinical trials & evidence
Clinical trials
Clinical trials: 5.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| PHASE2 | 3 |
| Not specified | 2 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT06303570 | PHASE2 | ACTIVE_NOT_RECRUITING | A Study to Evaluate the Efficacy and Safety of CBL-514 Compared to Placebo in Participants With Dercum’s Disease Lipomas |
| NCT03492840 | PHASE2 | COMPLETED | Treatment of Women With Lipedema Involving Substantial Fat Knee of Women and Men With Nodular Dercum’s Disease |
| NCT05387733 | PHASE2 | COMPLETED | A Study to Evaluate the Efficacy and Safety of CBL-514 in Participants With Dercum’s Disease Lipomas |
| NCT00833599 | Not specified | ENROLLING_BY_INVITATION | Imaging Lymphatic Function in Normal Subjects and in Persons With Lymphatic Disorders |
| NCT02838277 | Not specified | UNKNOWN | Insight Into Subcutaneous Adipose Tissue Disorders |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| UTENPANIUM CHLORIDE | 2 | 1 |
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.