Adjustment disorder
diseaseOn this page
Also known as adjustment reactiondisorder, adjustmentdisorder, reactivedisorders, adjustmentdisorders, reactive
Summary
Adjustment disorder (MONDO:0003265) is a disease with 1 GWAS associations across 7 studies and 57 clinical trials. Top therapeutic interventions include propranolol, risperidone, and midomafetamine. A subtype of mental disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- GWAS associations: 1
- Clinical trials: 57
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | adjustment disorder |
| Mondo ID | MONDO:0003265 |
| MeSH | D000275 |
| DOID | DOID:507 |
| ICD-11 | 264310751 |
| NCIT | C92191 |
| SNOMED CT | 17226007 |
| UMLS | C0001546 |
| MedGen | 1338 |
| Is cancer (heuristic) | no |
Also known as: adjustment disorder · adjustment reaction · disorder, adjustment · disorder, reactive · disorders, adjustment · disorders, reactive
Data availability: 1 GWAS association (7 studies).
Disease family
This is a subtype of mental disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by developmental or physiological process › psychiatric disorder › mental disorder › adjustment disorder
Related subtypes (13): akinetopsia, cortical deafness, pain agnosia, tactile agnosia, visual agnosia, psychosexual disorder, drug-induced mental disorder, alcohol-induced mental disorder, mood disorder, psychotic disorder, developmental disorder of mental health, anxiety disorder, disruptive behavior disorder
Genetics & variants
GWAS landscape
1 GWAS associations across 7 studies. Top hits map to 1 distinct genes (as reported by GWAS).
Top associations by p-value
| rsID | p-value | Gene | Risk allele | Odds ratio |
|---|---|---|---|---|
| rs138107094 | 5e-08 | LSAMP | ? |
Top studies (by case count)
| Study | Lead author | Year | Cases | Controls | Title |
|---|---|---|---|---|---|
| GCST90481814 | Verma A | 2024 | 71,046 | 341,619 | Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. |
| GCST90481813 | Verma A | 2024 | 29,136 | 78,829 | Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. |
| GCST90481811 | Verma A | 2024 | 11,821 | 41,093 | Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. |
| GCST90481812 | Verma A | 2024 | 1,079 | 5,079 | Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. |
| GCST90651724 | Liu TY | 2025 | 552 | 143,233 | Diversity and longitudinal records: Genetic architecture of disease associations and polygenic risk in the Taiwanese Han population. |
| GCST90435878 | Zhou W | 2018 | 295 | 365,476 | Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies. |
| GCST90043718 | Jiang L | 2021 | 241 | 456,107 | A generalized linear mixed model association tool for biobank-scale data. |
Variant details and genetic-evidence tiers
Tier distribution (top 50 variants)
| Tier | Variants |
|---|---|
| Tier 1: coding | 0 |
| Tier 2: splice/UTR | 0 |
| Tier 3: regulatory | 0 |
| Tier 4: intronic/intergenic | 1 |
MAF distribution
| Bucket | Variants |
|---|---|
| common (>=0.05) | 0 |
| low_freq (0.01-0.05) | 0 |
| rare (<0.01) | 0 |
| unknown | 1 |
Functional consequences
| Consequence | Count |
|---|---|
| intergenic_variant | 1 |
Top variants
| rsID | Chr | Pos | Alleles | MAF | Consequence | Gene | p-value | Tier |
|---|---|---|---|---|---|---|---|---|
| rs138107094 | 3 | 117109505 | C>G | intergenic_variant | LSAMP | 5e-08 | Tier 4: intronic/intergenic |
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
No approved or late-stage (phase ≥3) drug is indicated for this disease; the following are in earlier-phase trials only.
Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Fasedienol.
Clinical trials & evidence
Clinical trials
Clinical trials: 57.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 42 |
| PHASE2 | 7 |
| PHASE1 | 3 |
| PHASE3 | 2 |
| PHASE4 | 1 |
| PHASE2/PHASE3 | 1 |
| PHASE1/PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT06843044 | PHASE4 | RECRUITING | Efficacy and Safety of Ranquilon in Patients With Anxiety Disorders Due to Neurasthenia and Adjustment Disorders |
| NCT00399698 | PHASE3 | COMPLETED | Study to Determine Whether There Are Any Cognitive or Motor Effects From Taking the Medicine Risperidone. |
| NCT03151681 | PHASE2/PHASE3 | COMPLETED | The Trauma of Betrayal: Treating Adjustment Disorder With Reconsolidation Blockade Under Propranolol |
| NCT05586789 | PHASE3 | COMPLETED | A Study of the Efficacy and Safety of Ranquilon Tablets in Patients With Anxiety in Neurasthenia and Adjustment Disorders |
| NCT05455996 | PHASE2 | NOT_YET_RECRUITING | MDMA-Assisted Therapy for Stress Disorders in Healthcare Workers and First Responders |
| NCT05584826 | PHASE2 | RECRUITING | MDMA-assisted Therapy for Adjustment Disorder (AD) in Dyads of Patients With Cancer and a Concerned Significant Other |
| NCT07002034 | PHASE2 | RECRUITING | RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses |
| NCT07072728 | PHASE2 | RECRUITING | Psilocybin-Assisted Psychotherapy in Cancer Patients With Adjustment Disorder |
| NCT00883519 | PHASE1/PHASE2 | COMPLETED | The Efficacy of Parent Involvement in the Treatment of Adolescent Depression |
| NCT02822443 | PHASE2 | COMPLETED | Improve: Integrating Emotion Focused Components Into Psychological Therapy |
| NCT03152175 | PHASE2 | UNKNOWN | Posttraumatic Stress Disorders in Police, Correctional Service Officers, and 911 Operators |
| NCT04982211 | PHASE2 | UNKNOWN | Comparing Standard vs. Modified Reconsolidation Blockade for the Treatment of Psychological Trauma |
| NCT00619411 | PHASE1 | COMPLETED | Interpersonal Psychotherapy for Depressed Adolescents and Parents |
| NCT01039857 | PHASE1 | TERMINATED | Does an Integrative Neuro-psychotherapy Program Foster the Adjustment in Depressed Stroke Patients? A Randomized Controlled Study. |
| NCT01612104 | PHASE1 | COMPLETED | Psychological First Aid With Children in a High Risk Group - a Repeated Single Case Design |
| NCT04049890 | Not specified | RECRUITING | Development and Validation of Family Adjustment Inventory |
| NCT04900064 | Not specified | RECRUITING | Evaluation of Primary Care Behavioral Health (PCBH) With the Addition of Self-help CBT - A Randomized Multicenter Trial |
| NCT05963308 | Not specified | RECRUITING | Promoting Sustainable Return to Work Among Employees on Sick Leave Due to a Mental Health Condition: Evaluation of the HealthyMinds Online Group Intervention |
| NCT06433271 | Not specified | RECRUITING | Transdiagnostic Behavior Therapy Vs TAU for Adjustment Disorder Following Traumatic Event Exposure |
| NCT06885554 | Not specified | RECRUITING | Adjustment Disorders in the US Military: Disease Trajectories and ADNM-20-Mil Validation |
| NCT07221409 | Not specified | RECRUITING | Virtual Reality Intervention to Improve Psychological Symptom Burden for Cancer Patients Undergoing Treatment |
| NCT00153959 | Not specified | COMPLETED | Psychiatric Day Hospital Treatment |
| NCT00555503 | Not specified | COMPLETED | Registry of Mastectomy for Breast Cancer Risk Reduction |
| NCT01062880 | Not specified | UNKNOWN | Neuropattern - Assessment of a Translational Diagnostic Tool for Depression, Adjustment- and Somatoform-disorders |
| NCT01141933 | Not specified | UNKNOWN | Creating Meaning Following Cancer: An Intervention to Improve Existential and Global Quality of Life |
| NCT01234961 | Not specified | COMPLETED | Outcome Study of the ReDO Intervention for Women With Stress-related Disorders |
| NCT01805583 | Not specified | COMPLETED | Return to Work: Promoting Health and Productivity in Workers With Common Mental Disorders |
| NCT02291068 | Not specified | UNKNOWN | Psychological Flexibility and Effectiveness of Psychotherapy |
| NCT02452411 | Not specified | COMPLETED | Efficacy of Two Ways of Applying Homework Assignments in the Treatment of Adjustment Disorders |
| NCT02540317 | Not specified | COMPLETED | Internet-based Cognitive Behavior Therapy for Stress Disorders: a Randomized Trial |
| NCT02621775 | Not specified | COMPLETED | Effectiveness of Two Stress Management Programs in Adaptation Disorder With Anxiety (ADA) |
| NCT02885519 | Not specified | COMPLETED | Integrated Mental Health Care and Vocational Rehabilitation to Individuals on Sick Leave Due to Stress Disorders |
| NCT02905071 | Not specified | COMPLETED | Validation of a Scale of Well-being at Work |
| NCT02972203 | Not specified | COMPLETED | MINDFUL-PC: Integrating Mindfulness Into the Patient-Centered Medical Home |
| NCT03022760 | Not specified | COMPLETED | Return to Work Among Patients With Stress Related Mental Disorders - An Intervention in the Swedish Primary Care |
| NCT03265600 | Not specified | COMPLETED | Integrating Mindfulness Into the Patient-Centered Medical Home (Phase 2) |
| NCT03346395 | Not specified | COMPLETED | A Problem Solving Based Intervention for Facilitating Return-to-work Among People Suffering From Common Mental Disorders |
| NCT03358056 | Not specified | UNKNOWN | Effects of Mindfulness Based Cognitive Therapy on Emotional Processing |
| NCT03360136 | Not specified | COMPLETED | Open Clinical Trial of CBT-based Multiprofessional Rehabilitation for Exhaustion Disorder |
| NCT03379155 | Not specified | COMPLETED | Internet-based Self-help for Negative Life Events |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| PROPRANOLOL | 4 | 3 |
| RISPERIDONE | 4 | 1 |
| MIDOMAFETAMINE | 3 | 2 |
| FABOMOTIZOLE | 3 | 1 |
| DEXPROPRANOLOL | 2 | 1 |
Related Atlas pages
- Drugs: Propranolol, Risperidone, Midomafetamine, Fabomotizole