Adrenal gland neoplasm
diseaseOn this page
Also known as adrenal gland neoplasm (disease)adrenal gland tumoradrenal gland tumouradrenal neoplasmadrenal neoplasmsadrenal tumoradrenal tumouradrenal/paraganglial tumourADRENAL_GLANDneoplasm of adrenal glandneoplasm of the adrenal glandtumor of adrenal glandtumor of the adrenal glandtumour of adrenal glandtumour of the adrenal gland
Summary
Adrenal gland neoplasm (MONDO:0021227) is a cancer (an umbrella term covering 8 Mondo subtypes) and 42 clinical trials. Top therapeutic interventions include floxuridine, lutetium oxodotreotide lu-177, and pertuzumab. A subtype of endocrine gland neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Umbrella term: 8 Mondo subtypes
- Clinical trials: 42
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | adrenal gland neoplasm |
| Mondo ID | MONDO:0021227 |
| EFO | EFO:0003850 |
| Orphanet | 100091 |
| NCIT | C2859 |
| UMLS | C0001624 |
| MedGen | 1352 |
| GARD | 0019765 |
| Anatomy (UBERON) | UBERON:0002369 |
| Is cancer (heuristic) | yes |
Also known as: adrenal gland neoplasm (disease) · adrenal gland tumor · adrenal gland tumour · adrenal neoplasm · adrenal neoplasms · adrenal tumor · adrenal tumour · adrenal/paraganglial tumour · ADRENAL_GLAND · neoplasm of adrenal gland · neoplasm of the adrenal gland · tumor of adrenal gland · tumor of the adrenal gland · tumour of adrenal gland · tumour of the adrenal gland
Disease family
This is a subtype of endocrine gland neoplasm. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › endocrine gland neoplasm › adrenal gland neoplasm
Related subtypes (13): benign endocrine neoplasm, thymus neoplasm, granulosa cell tumor, thyroid tumor, pituitary tumor, familial tumoral calcinosis, neuroendocrine neoplasm, malignant endocrine neoplasm, non-functioning endocrine neoplasm, functioning endocrine neoplasm, pineal body neoplasm, tumor of parathyroid gland, liver and intrahepatic bile duct neoplasm
Subtypes (8): adrenal gland cancer, multiple endocrine neoplasia type 1, Cushing disease due to pituitary adenoma, pituitary dermoid and epidermoid cysts, adrenal medulla neoplasm, benign neoplasm of adrenal gland, pheochromocytoma-paraganglioma, adrenal cortex neoplasm
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 42.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 28 |
| PHASE2 | 4 |
| PHASE4 | 2 |
| PHASE2/PHASE3 | 2 |
| PHASE1/PHASE2 | 2 |
| PHASE1 | 2 |
| PHASE3 | 1 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01959711 | PHASE4 | COMPLETED | Randomized Clinical Trial of Posterior Retroperitoneoscopic Adrenalectomy Versus Lateral Laparoscopic Adrenalectomy |
| NCT06576336 | PHASE4 | COMPLETED | A Randomized Clinical Trial About Use of 3D Laparoscopy Versus 2D Laparoscopy in Adrenal Surgery |
| NCT06100367 | PHASE2/PHASE3 | ACTIVE_NOT_RECRUITING | 11C-Metomidate PET/CT for Endocrine Hypertension and Characterisation of Adrenal Tumours |
| NCT00037843 | PHASE3 | COMPLETED | Iodine I-131 Iodocholesterol, Its Use in Adrenal Screening |
| NCT00997594 | PHASE2/PHASE3 | COMPLETED | Changes in Adrenal Hormones During Adrenal Radiofrequency Ablation |
| NCT05286814 | PHASE2 | RECRUITING | PDS01ADC in Combination With Hepatic Artery Infusion Pump (HAIP) and Systemic Therapy for Subjects With Metastatic Colorectal Cancer, Intrahepatic Cholangiocarcinoma, or Metastatic Adrenocortical Carcinoma |
| NCT06607692 | PHASE1/PHASE2 | RECRUITING | Study in Children and Adolescents of 177Lu-DOTATATE (Lutathera®) Combined With the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed). |
| NCT06638931 | PHASE2 | RECRUITING | Agnostic Therapy in Rare Solid Tumors |
| NCT00454103 | PHASE1/PHASE2 | COMPLETED | Evaluation of 123I-Iodometomidate for Adrenal Scintigraphy |
| NCT00947167 | PHASE2 | TERMINATED | A Phase II Study of Pertuzumab and Erlotinib for Metastatic or Unresectable Neuroendocrine Tumors |
| NCT02001051 | PHASE2 | TERMINATED | Study of Adrenalectomy Versus Observation for Subclinical Hypercortisolism |
| NCT06910657 | PHASE1 | RECRUITING | IDOV-Immune for Advanced Solid Tumors |
| NCT00591643 | PHASE1 | COMPLETED | Adrenal Scans With Radioiodine-Labeled Norcholesterol (NP-59) |
| NCT04804163 | EARLY_PHASE1 | COMPLETED | Research on the Effectiveness and Safety of Remote Control of Domestic Surgical Robot System for Urinary Surgery |
| NCT00669266 | Not specified | RECRUITING | Adrenal Tumors - Pathogenesis and Therapy |
| NCT01005654 | Not specified | RECRUITING | Prospective Comprehensive Molecular Analysis of Endocrine Neoplasms |
| NCT03374215 | Not specified | RECRUITING | Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks |
| NCT04127552 | Not specified | RECRUITING | Impact of Adrenal IncidenTalomas and Possible Autonomous Cortisol Secretion on Cardiovascular and Metabolic Alterations |
| NCT04905706 | Not specified | RECRUITING | 3D Laparoscopic Adrenalectomies for Adrenal Tumors |
| NCT06050057 | Not specified | RECRUITING | Surgical Treatment of Adrenal Diseases- Laparoscopic vs. Robotic-assisted Adrenalectomy |
| NCT06520111 | Not specified | RECRUITING | CRISAL Study:Cancer Risk In Secreting Adrenal Lesions |
| NCT06870396 | Not specified | ENROLLING_BY_INVITATION | National Study of Adrenal Tumours |
| NCT07182175 | Not specified | ENROLLING_BY_INVITATION | Comparative Study of Perioperative Cardiac Injury in Patients With Functional Adrenal Tumors |
| NCT00005927 | Not specified | COMPLETED | Study of Adrenal Gland Tumors |
| NCT00713115 | Not specified | UNKNOWN | Prospective Randonmized Comparison of Needlescopic Versus Conventional Laparoscopic Adrenalectomy |
| NCT00894335 | Not specified | UNKNOWN | Anesthesia Management of Retroperitoneal Adrenalectomies |
| NCT01284829 | Not specified | COMPLETED | Performance of 18F-Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) in the Diagnosis of Indeterminate Adrenal Tumors on Conventional Imaging: A French Prospective Multicentric Study |
| NCT01348698 | Not specified | TERMINATED | Evaluation of Molecular Markers in Adrenal Tumors |
| NCT01465425 | Not specified | UNKNOWN | Extracolonic Findings on Computed Tomography (CT) Colonography |
| NCT02672020 | Not specified | COMPLETED | Towards an Easy-to-use Adrenal Cancer/Tumor Identity Card |
| NCT03327142 | Not specified | COMPLETED | EUS-guided FNA in the Study of the Adrenal Gland |
| NCT03469102 | Not specified | COMPLETED | 18FDG PET Textural Indices in Adrenal Lesion |
| NCT03739918 | Not specified | COMPLETED | Rare Cystic Benign Adrenal Incidentalomas |
| NCT03830593 | Not specified | COMPLETED | Laparoscopic Adrenalectomy for Large Adrenal Tumors. |
| NCT03986593 | Not specified | TERMINATED | Cryoablation of Bone Metastases From Endocrine Tumors |
| NCT04071561 | Not specified | COMPLETED | Prevention of Conversion in Posterior Retroperitoneal Adrenalectomy by Measuring Preoperative Anatomical Conditions |
| NCT04432532 | Not specified | WITHDRAWN | Neuroendocrine and Adrenal Tumors |
| NCT04570176 | Not specified | COMPLETED | Efficacy and Safety of Clinical Telesurgery Using Chinese Independently Developed Surgical Robot System |
| NCT05739812 | Not specified | UNKNOWN | The Efficacy and Safety of Chinese Domestic Surgical Robot System in Urological Telesurgery |
| NCT05888753 | Not specified | COMPLETED | Textbook Outcome in Adrenal Neoplasms |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| FLOXURIDINE | 4 | 1 |
| LUTETIUM OXODOTREOTIDE LU-177 | 4 | 1 |
| PERTUZUMAB | 4 | 1 |
| IODOCHOLESTEROL I 131 | 2 | 1 |
| ZENIDOLOL | 2 | 1 |
| IODOMETOMIDATE I-123, R- | 1 | 1 |