Adult brainstem glioma

Summary

Adult brainstem glioma (MONDO:0003153) is a cancer and 27 clinical trials. Top therapeutic interventions include bevacizumab, edotreotide gallium ga-68, and fluorodopa f 18. A subtype of brain stem glioma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Clinical trials: 27

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	adult brainstem glioma
Mondo ID	MONDO:0003153
DOID	DOID:4813
NCIT	C9091
UMLS	C0278873
MedGen	124526
GARD	0023387
Is cancer (heuristic)	yes

Also known as: adult brain stem glioma · adult brainstem glioma · adult brainstem neuroglial neoplasm · adult brainstem neuroglial tumor · adult brainstem neuroglial tumour · brain stem glioma · brain stem glioma of adults · glioma of adult brain stem · glioma of the adult brain stem

Disease family

This is a subtype of brain stem glioma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: cancer or benign tumor › neoplastic disease or syndrome › neoplasm › cancer › nervous system cancer › central nervous system cancer › brain cancer › infratentorial cancer › brainstem cancer › brain stem glioma › adult brainstem glioma

Related subtypes (4): brain stem astrocytic neoplasm, brain stem ependymoma, childhood brain stem glioma, brain stem glioblastoma

Subtypes (3): adult brainstem gliosarcoma, adult brainstem mixed glioma, adult brainstem astrocytoma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 27.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE1	11
PHASE2	5
Not specified	4
PHASE1/PHASE2	3
PHASE3	2
PHASE2/PHASE3	1
EARLY_PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT02864888	PHASE3	NOT_YET_RECRUITING	Effect of Antineoplaston Therapy on the QT/QTc Interval In Subjects With Diffuse, Intrinsic, Brainstem Glioma
NCT02887040	PHASE3	NOT_YET_RECRUITING	Study of Antineoplaston Therapy + Radiation vs. Radiation Only in Diffuse, Intrinsic, Brainstem Glioma
NCT01236560	PHASE2/PHASE3	COMPLETED	Vorinostat, Temozolomide, or Bevacizumab in Combination With Radiation Therapy Followed by Bevacizumab and Temozolomide in Young Patients With Newly Diagnosed High-Grade Glioma
NCT00840047	PHASE2	ACTIVE_NOT_RECRUITING	Methionine PET/CT Studies In Patients With Cancer
NCT00003459	PHASE2	COMPLETED	Antineoplaston Therapy in Treating Patients With Brain Stem Glioma
NCT00492089	PHASE2	COMPLETED	Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer
NCT01024907	PHASE1/PHASE2	COMPLETED	Proton Beam Radiation Therapy in Treating Patients With Low Grade Gliomas
NCT01095094	PHASE2	TERMINATED	Ritonavir and Lopinavir in Treating Patients With Progressive or Recurrent High-Grade Glioma
NCT01514201	PHASE1/PHASE2	COMPLETED	Veliparib, Radiation Therapy, and Temozolomide in Treating Younger Patients With Newly Diagnosed Diffuse Pontine Gliomas
NCT01884740	PHASE1/PHASE2	TERMINATED	Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22
NCT03932981	PHASE2	UNKNOWN	First-line Chemotherapy With Temozolomide Alone for Non-enhancing Adult Brainstem Gliomas, With a Diffuse Subtype and Showing Clinical and/or Radiological Infiltrative Pattern of Progression
NCT00019578	PHASE1	COMPLETED	Stereotactic Radiosurgery in Treating Patients With Brain Tumors
NCT00030498	PHASE1	COMPLETED	Erlotinib in Treating Patients With Solid Tumors and Liver or Kidney Dysfunction
NCT00110032	PHASE1	TERMINATED	Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Newly Diagnosed Brain Tumors
NCT00576641	PHASE1	COMPLETED	Immunotherapy for Patients With Brain Stem Glioma and Glioblastoma
NCT01082926	PHASE1	COMPLETED	Phase I Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Intratumoral Infusions of GRm13Z40-2, An Allogeneic CD8+ Cytolitic T-Cell Line Genetically Modified to Express the IL 13-Zetakine and HyTK and to be Resistant to Glucocorticoids, in Combination With Interleukin-2
NCT01119599	PHASE1	COMPLETED	RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma
NCT01131234	PHASE1	COMPLETED	Gamma-Secretase Inhibitor RO4929097 and Cediranib Maleate in Treating Patients With Advanced Solid Tumors
NCT01269411	PHASE1	TERMINATED	RO4929097 in Treating Patients With Recurrent Invasive Gliomas
NCT01502917	PHASE1	COMPLETED	Convection-Enhanced Delivery of 124I-Omburtamab for Patients With Non-Progressive Diffuse Pontine Gliomas Previously Treated With External Beam Radiation Therapy
NCT02186509	PHASE1	COMPLETED	Alisertib and Fractionated Stereotactic Radiosurgery in Treating Patients With Recurrent High Grade Gliomas
NCT03396575	PHASE1	TERMINATED	Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I)
NCT01165632	EARLY_PHASE1	COMPLETED	Fluorine F 18 Fluorodopa-Labeled PET Scan in Planning Surgery and Radiation Therapy in Treating Patients With Newly Diagnosed High- or Low-Grade Malignant Glioma
NCT01234805	Not specified	TERMINATED	Yoga Therapy in Treating Patients With Malignant Brain Tumors
NCT02175745	Not specified	TERMINATED	18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or Recurrent Gliomas
NCT02194452	Not specified	WITHDRAWN	Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors
NCT02967380	Not specified	TERMINATED	Gadobutrol Versus Gadopentetate Dimeglumine or Gadobenate Dimeglumine Before DCE-MRI in Diagnosing Patients With Multiple Sclerosis, Grade II-IV Glioma, or Brain Metastases

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
BEVACIZUMAB	4	3
EDOTREOTIDE GALLIUM GA-68	4	1
FLUORODOPA F 18	4	1
GADOBENATE DIMEGLUMINE	4	1
GADOBUTROL	4	1
GADOPENTETATE DIMEGLUMINE	4	1
TEMOZOLOMIDE	4	1
VORINOSTAT	4	1
ANTINEOPLASTON A10	3	2
VELIPARIB	3	2
ALISERTIB	3	1
CEDIRANIB MALEATE	3	1
METHIONINE	3	1
CHEMBL4228794	0	1
CHEMBL4248195	0	1
CHEMBL1234268	0	1
RACEMETHIONINE	-1	1