Adult central nervous system germ cell tumor

disease

On this page

Also known as adult central nervous system germ cell neoplasmadult CNS germ cell neoplasmadult CNS germ cell tumoradult CNS germ cell tumourcentral nervous system adult germ cell tumourcentral nervous system germ cell tumorcentral nervous system germ cell tumor of adultscentral nervous system germ cell tumourcentral nervous system germ cell tumour of adultsgerm cell neoplasm of adult central nervous systemgerm cell neoplasm of adult CNSgerm cell neoplasm of the adult central nervous systemgerm cell neoplasm of the adult CNSgerm cell tumor of adult central nervous systemgerm cell tumor of adult CNSgerm cell tumor of the adult central nervous systemgerm cell tumor of the adult CNSgerm cell tumour of adult central nervous systemgerm cell tumour of adult CNS

Summary

Adult central nervous system germ cell tumor (MONDO:0003405) is a cancer (an umbrella term covering 5 Mondo subtypes) and 8 clinical trials. Top therapeutic interventions include bevacizumab, palbociclib, and palifosfamide. A subtype of central nervous system germ cell tumor — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

Classification: Cancer
Umbrella term: 5 Mondo subtypes
Clinical trials: 8

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	adult central nervous system germ cell tumor
Mondo ID	MONDO:0003405
DOID	DOID:5349
NCIT	C6285
UMLS	C0280796
MedGen	128893
GARD	0023505
Is cancer (heuristic)	yes

Also known as: adult central nervous system germ cell neoplasm · adult central nervous system germ cell tumor · adult CNS germ cell neoplasm · adult CNS germ cell tumor · adult CNS germ cell tumour · central nervous system adult germ cell tumour · central nervous system germ cell tumor · central nervous system germ cell tumor of adults · central nervous system germ cell tumour · central nervous system germ cell tumour of adults · germ cell neoplasm of adult central nervous system · germ cell neoplasm of adult CNS · germ cell neoplasm of the adult central nervous system · germ cell neoplasm of the adult CNS · germ cell tumor of adult central nervous system · germ cell tumor of adult CNS · germ cell tumor of the adult central nervous system · germ cell tumor of the adult CNS · germ cell tumour of adult central nervous system · germ cell tumour of adult CNS (+1 more)

Disease family

This is a subtype of central nervous system germ cell tumor. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › central nervous system neoplasm › central nervous system germ cell tumor › adult central nervous system germ cell tumor

Related subtypes (5): malignant pineal area germ cell neoplasm, central nervous system germinoma, childhood central nervous system germ cell tumor, mixed germ cell tumor of central nervous system, central nervous system nongerminomatous germ cell tumor

Subtypes (5): adult central nervous system teratoma, adult central nervous system choriocarcinoma, adult central nervous system embryonal carcinoma, adult central nervous system germinoma, adult central nervous system mixed germ cell tumor

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 8.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE1	4
PHASE2	3
Not specified	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00492089	PHASE2	COMPLETED	Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer
NCT01037790	PHASE2	COMPLETED	Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer
NCT01808534	PHASE2	TERMINATED	Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors
NCT00019578	PHASE1	COMPLETED	Stereotactic Radiosurgery in Treating Patients With Brain Tumors
NCT00110032	PHASE1	TERMINATED	Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Newly Diagnosed Brain Tumors
NCT00638898	PHASE1	COMPLETED	Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor
NCT04521946	PHASE1	WITHDRAWN	Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain Cancer
NCT01049230	Not specified	ACTIVE_NOT_RECRUITING	Proton Beam Radiation Therapy for Central Nervous System (CNS) Germ Cell Tumors

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
BEVACIZUMAB	4	1
PALBOCICLIB	4	1
PALIFOSFAMIDE	3	1

Drugs: Bevacizumab, Palbociclib, Palifosfamide