Adult pineoblastoma
diseaseOn this page
Also known as pineoblastomapineoblastoma of adults
Summary
Adult pineoblastoma (MONDO:0003957) is a disease and 25 clinical trials. Top therapeutic interventions include etoposide phosphate, plerixafor, and bevacizumab. A subtype of adult pineal parenchymal tumor — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 25
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | adult pineoblastoma |
| Mondo ID | MONDO:0003957 |
| DOID | DOID:6648 |
| NCIT | C8292 |
| UMLS | C0281332 |
| MedGen | 83794 |
| GARD | 0023751 |
| Is cancer (heuristic) | no |
Also known as: adult pineoblastoma · pineoblastoma · pineoblastoma of adults
Data availability: 6 cell lines.
Disease family
This is a subtype of adult pineal parenchymal tumor. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › nervous system neoplasm › neuroepithelial neoplasm › pineal parenchymal cell neoplasm › adult pineal parenchymal tumor › adult pineoblastoma
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 25.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| PHASE1 | 10 |
| Not specified | 8 |
| PHASE2 | 3 |
| PHASE1/PHASE2 | 2 |
| EARLY_PHASE1 | 2 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00179803 | PHASE2 | COMPLETED | Stem Cell Transplant for High Risk Central Nervous System (CNS) Tumors |
| NCT01217437 | PHASE2 | COMPLETED | Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors |
| NCT01977677 | PHASE1/PHASE2 | COMPLETED | Plerixafor After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed High Grade Glioma |
| NCT02095132 | PHASE1/PHASE2 | COMPLETED | Adavosertib and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid Tumors |
| NCT02596828 | PHASE2 | COMPLETED | Prospective Pilot Trial to Assess a Multimodal Molecular Targeted Therapy in Children, Adolescent and Young Adults With Relapsed or Refractory High-grade Pineoblastoma |
| NCT03500991 | PHASE1 | ACTIVE_NOT_RECRUITING | HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors |
| NCT06193759 | PHASE1 | RECRUITING | Immunotherapy for Malignant Pediatric Brain Tumors Employing Adoptive Cellular Therapy (IMPACT) |
| NCT07087002 | PHASE1 | RECRUITING | GPC2-CAR T Cell Therapy for Relapsed or Refractory Medulloblastoma in Children and Young Adults |
| NCT07390539 | PHASE1 | NOT_YET_RECRUITING | B7-H3.CD28Z.CART in CNS Neoplasms |
| NCT00110032 | PHASE1 | TERMINATED | Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Newly Diagnosed Brain Tumors |
| NCT00867178 | PHASE1 | COMPLETED | Vorinostat Combined With Isotretinoin and Chemotherapy in Treating Younger Patients With Embryonal Tumors of the Central Nervous System |
| NCT01119599 | PHASE1 | COMPLETED | RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma |
| NCT03434262 | PHASE1 | COMPLETED | SJDAWN: St. Jude Children’s Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors |
| NCT03638167 | PHASE1 | COMPLETED | EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors |
| NCT03990597 | PHASE1 | WITHDRAWN | StrataXRT in Preventing Radiation Dermatitis in Pediatric Patients Undergoing Radiation Therapy to the Brain or Spinal Cord |
| NCT06942039 | EARLY_PHASE1 | RECRUITING | Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation |
| NCT07017816 | EARLY_PHASE1 | RECRUITING | A Phase 0/1 Study of cDNA for TP53, Checkpoint Inhibition and Radiation in Children With Recurrent, Progressive or Refractory CNS Malignancies. |
| NCT03382158 | Not specified | RECRUITING | International PPB/DICER1 Registry |
| NCT00565903 | Not specified | COMPLETED | Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome |
| NCT01063114 | Not specified | COMPLETED | Proton Beam Radiotherapy for Medulloblastoma and Pineoblastoma |
| NCT01234805 | Not specified | TERMINATED | Yoga Therapy in Treating Patients With Malignant Brain Tumors |
| NCT01884194 | Not specified | COMPLETED | Morphological Analysis of the Pineal Gland in Pediatric Retinoblastoma Patients Using Magnetic Resonance Imaging |
| NCT02194452 | Not specified | WITHDRAWN | Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors |
| NCT02967380 | Not specified | TERMINATED | Gadobutrol Versus Gadopentetate Dimeglumine or Gadobenate Dimeglumine Before DCE-MRI in Diagnosing Patients With Multiple Sclerosis, Grade II-IV Glioma, or Brain Metastases |
| NCT05934630 | Not specified | TERMINATED | Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| ETOPOSIDE PHOSPHATE | 4 | 2 |
| PLERIXAFOR | 4 | 2 |
| BEVACIZUMAB | 4 | 1 |
| EDOTREOTIDE GALLIUM GA-68 | 4 | 1 |
| GADOBENATE DIMEGLUMINE | 4 | 1 |
| GADOBUTROL | 4 | 1 |
| GADOPENTETATE DIMEGLUMINE | 4 | 1 |
| ISOTRETINOIN | 4 | 1 |
| SONIDEGIB | 4 | 1 |
| ADAVOSERTIB | 2 | 1 |