Adult teratoma
diseaseOn this page
Also known as teratomateratoma of adults
Summary
Adult teratoma (MONDO:0003516) is a disease and 20 clinical trials. Top therapeutic interventions include cisplatin, bleomycin sulfate, and 2-mercaptoethanesulfonic acid. A subtype of teratoma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 20
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | adult teratoma |
| Mondo ID | MONDO:0003516 |
| DOID | DOID:5565 |
| NCIT | C9013 |
| UMLS | C1368898 |
| MedGen | 277966 |
| GARD | 0023543 |
| Is cancer (heuristic) | no |
Also known as: adult teratoma · teratoma · teratoma of adults
Data availability: 1 cell line.
Disease family
This is a subtype of teratoma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › germ cell tumor › nongerminomatous germ cell tumor › teratoma › adult teratoma
Related subtypes (12): cystic teratoma, central nervous system teratoma, gastric teratoma, malignant teratoma, fallopian tube teratoma, mature teratoma, mediastinum teratoma, gonadal teratoma, teratoma with malignant transformation, nasopharyngeal teratoma, immature teratoma, sacrococcygeal teratoma
Subtypes (2): adult central nervous system teratoma, adult cystic teratoma
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 20.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| PHASE2 | 9 |
| Not specified | 7 |
| PHASE3 | 2 |
| PHASE2/PHASE3 | 1 |
| PHASE1/PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT02375204 | PHASE3 | ACTIVE_NOT_RECRUITING | Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients with Relapsed or Refractory Germ Cell Tumors |
| NCT00003643 | PHASE2/PHASE3 | UNKNOWN | Combination Chemotherapy in Treating Men With Germ Cell Cancer |
| NCT00104676 | PHASE3 | COMPLETED | Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors |
| NCT00002931 | PHASE2 | COMPLETED | Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer |
| NCT00301782 | PHASE2 | COMPLETED | Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors |
| NCT00423852 | PHASE1/PHASE2 | COMPLETED | Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin |
| NCT00432094 | PHASE2 | COMPLETED | Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors |
| NCT00453232 | PHASE2 | COMPLETED | Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors |
| NCT00453310 | PHASE2 | COMPLETED | Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment |
| NCT00470366 | PHASE2 | COMPLETED | Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors |
| NCT01037790 | PHASE2 | COMPLETED | Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer |
| NCT01808534 | PHASE2 | TERMINATED | Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors |
| NCT02300987 | PHASE2 | COMPLETED | A Randomized, Blinded, Placebo-controlled, Phase II Trial of LEE011 in Patients With Relapsed, Refractory, Incurable Teratoma With Recent Progression |
| NCT05564026 | Not specified | RECRUITING | Molecular Epidemiology of Pediatric Germ Cell Tumors |
| NCT06421805 | Not specified | RECRUITING | Establishing Prospective Mediastinal Tumor Database of PUMCH |
| NCT07199699 | Not specified | NOT_YET_RECRUITING | Subxiphoid VATS for Giant Mediastinal Teratoma |
| NCT00687778 | Not specified | UNKNOWN | 11C-Acetate PET/CT Non-FDG-Avid Tumors |
| NCT00836121 | Not specified | COMPLETED | Anterior Mediastinum Teratoma: A Case Report |
| NCT05179850 | Not specified | UNKNOWN | Computer Aided Diagnostic Tool on Computed Tomography Images for Diagnosis of Retroperitoneal Tumor in Children |
| NCT05187923 | Not specified | UNKNOWN | Computer Aided Tool for Diagnosis of Neck Masses in Children |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| CISPLATIN | 4 | 6 |
| BLEOMYCIN SULFATE | 4 | 4 |
| 2-MERCAPTOETHANESULFONIC ACID | 4 | 2 |
| ETOPOSIDE PHOSPHATE | 4 | 2 |
| IFOSFAMIDE | 4 | 2 |
| ETOPOSIDE | 4 | 1 |
| FILGRASTIM | 4 | 1 |
| OXALIPLATIN | 4 | 1 |
| PACLITAXEL | 4 | 1 |
| PALBOCICLIB | 4 | 1 |
| RIBOCICLIB | 4 | 1 |
| SUNITINIB MALATE | 4 | 1 |
| THIOTEPA | 4 | 1 |
| PALIFOSFAMIDE | 3 | 1 |
| CHEMBL48 | 0 | 1 |
| CHEMBL3109278 | 0 | 1 |