Advanced heart failure
disease diseaseOn this page
Summary
Advanced heart failure (MONDO:0005257) is a disease and 27 clinical trials. Top therapeutic interventions include levosimendan. A subtype of symptomatic heart failure — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 27
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | advanced heart failure |
| Mondo ID | MONDO:0005257 |
| EFO | EFO:0003149 |
| Is cancer (heuristic) | no |
Disease family
Classification path: disease › human disease › disease by body system or component › cardiovascular disorder › heart disorder › heart failure › symptomatic heart failure › advanced heart failure
Related subtypes (2): mild heart failure, moderate heart failure
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 27.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 24 |
| PHASE4 | 3 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT07081035 | PHASE4 | NOT_YET_RECRUITING | Trial of Low-intensity Anticoagulation to Reduce GI or Other Bleeding Complications With Equivalent Therapeutic Efficacy in HeartMate 3 LVAD Patients |
| NCT00988806 | PHASE4 | UNKNOWN | Long-Term Intermittent Administration of Levosimendan in Patients With Advanced Heart Failure |
| NCT05284955 | PHASE4 | UNKNOWN | Screening for Advanced Heart Failure IN Stable outPatientS - The SAINTS Study (SAINTS B) |
| NCT04475393 | Not specified | ACTIVE_NOT_RECRUITING | Carmat Total Artificial Heart as a Bridge to Transplant in Patients With Advanced Heart Failure |
| NCT05271214 | Not specified | RECRUITING | Conservative Management of Left Ventricular Assist Device Candidates |
| NCT06228209 | Not specified | ENROLLING_BY_INVITATION | Tier - Palliative Care For Patients With Advanced Heart Failure or Cancer |
| NCT06823583 | Not specified | RECRUITING | Multi-Site Feasibility Testing of the Ventricular Assist Device Anticipatory Guidance Tool |
| NCT06907017 | Not specified | RECRUITING | CorWave LVAS FIH Study |
| NCT07051356 | Not specified | NOT_YET_RECRUITING | Wearables and Artificial Intelligence in Advanced Heart Failure Care |
| NCT07233876 | Not specified | NOT_YET_RECRUITING | DuoCor 2 DOMINATE Study |
| NCT07391956 | Not specified | NOT_YET_RECRUITING | Tier Palliative Care For Patients With Advanced Heart Failure or Cancer |
| NCT07445932 | Not specified | NOT_YET_RECRUITING | Palliative Care Intervention to Improve Health Related Quality of Life for Patients on Long-Term LVAD Support |
| NCT07497308 | Not specified | RECRUITING | GDF-15 and Early Outcomes After LVAD Implantation |
| NCT07611188 | Not specified | NOT_YET_RECRUITING | REACTION-VAD Trial: Remote Exercise Training Via Telemedicine in Patients With Long-Term Ventricular Assist Devices |
| NCT00572286 | Not specified | WITHDRAWN | Non-invasive Evaluation of Heart Transplant Rejection- Pilot Study |
| NCT00690157 | Not specified | COMPLETED | Registry of Patients Referred for Heart Transplantation |
| NCT01210573 | Not specified | COMPLETED | Prospective Observation of Exercise Parameters in Advanced Heart Failure |
| NCT01626404 | Not specified | COMPLETED | Screening for Advanced Heart Failure Treatment (SEE-HF) |
| NCT01643551 | Not specified | COMPLETED | Neuron Specific Enolase in Ventricular Assist Device Recipients |
| NCT02962973 | Not specified | SUSPENDED | European Clinical Evaluation of the Carmat Total Artificial Heart |
| NCT03526627 | Not specified | UNKNOWN | Advanced Care Management in Patients With Advanced Heart Failure |
| NCT03874312 | Not specified | UNKNOWN | Ultrasound-assessed Internal Jugular Vein Distensibility in Advanced Chronic Heart Failure (US-IJVD in CHF) |
| NCT03919136 | Not specified | UNKNOWN | Wrist Worn Blood Pressure Measurement |
| NCT04423562 | Not specified | UNKNOWN | PROgnostic Value of Exercise Capacity Measured as Peak Oxygen Uptake (pVO2) in Recipients of Left Ventricular Assist Devices |
| NCT04703855 | Not specified | TERMINATED | Hong Kong and Taiwan HM3 PMS |
| NCT04915924 | Not specified | COMPLETED | Post Market Surveillance of the HeartMate 3 Left Ventricular Assist System in Korea |
| NCT06259045 | Not specified | UNKNOWN | Cardiac Cachexia in Advanced Heart Failure |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| LEVOSIMENDAN | 3 | 1 |
Related Atlas pages
- Drugs: Levosimendan