AIDS related complex

Summary

AIDS related complex (MONDO:0005639) is a disease and 3 clinical trials. Top therapeutic interventions include didanosine, zidovudine, and interferon gamma-1a. A subtype of HIV infectious disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 3

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	AIDS related complex
Mondo ID	MONDO:0005639
EFO	EFO:0007137
MeSH	D000386
UMLS	C0001857
MedGen	1793
Is cancer (heuristic)	no

Disease family

This is a subtype of HIV infectious disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › reproductive system disorder › sexually transmitted disease › viral sexually transmitted disease › HIV infectious disease › AIDS related complex

Related subtypes (4): central nervous system AIDS arteritis, HIV wasting syndrome, AIDS, congenital human immunodeficiency virus

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

0 approved, 2 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Didanosine	Phase 3 (in late-stage trials)
Zidovudine	Phase 3 (in late-stage trials)

Clinical trials & evidence

Clinical trials

Clinical trials: 3.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE3	1
PHASE2	1
Not specified	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00001267	PHASE3	COMPLETED	A Randomized Pilot Study for the Treatment of AIDS or AIDS Related Complex With an Alternating or Simultaneous Combination Regimen of AZT and 2’,3’-Dideoxyinosine
NCT00201123	PHASE2	COMPLETED	Effects of Interferon-Gamma on Cavitary Pulmonary Tuberculosis in the Lungs
NCT00005273	Not specified	COMPLETED	Pulmonary Complications of HIV Infection Study (PACS)

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
DIDANOSINE	4	1
ZIDOVUDINE	4	1
INTERFERON GAMMA-1A	3	1
CHEMBL26318	0	1