Alcohol abuse

Summary

Alcohol abuse (MONDO:0002046) is a disease and 822 clinical trials. Top therapeutic interventions include naltrexone, acamprosate, and prazosin. A subtype of substance abuse — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 822

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	alcohol abuse
Mondo ID	MONDO:0002046
MeSH	D000437
DOID	DOID:1574
ICD-10-CM	F10.1
SNOMED CT	15167005
UMLS	C0085762
MedGen	39339
Is cancer (heuristic)	no

Also known as: abuse, alcohol · addiction, alcohol · alcohol abuse · alcohol addiction · alcohol dependence · alcoholic intoxication, chronic · alcoholism · chronic alcoholic intoxication · dependence, alcohol · intoxication, chronic alcoholic

Disease family

This is a subtype of substance abuse. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by developmental or physiological process › psychiatric disorder › substance-related disorder › substance abuse › alcohol abuse

Related subtypes (7): opioid abuse, antidepressant type abuse, hallucinogen abuse, amphetamine abuse, cocaine abuse, barbiturate abuse, phencyclidine abuse

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

5 approved, 21 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Acamprosate	Approved (phase 4)
Chlordiazepoxide	Approved (phase 4)
Disulfiram	Approved (phase 4)
Nalmefene	Approved (phase 4)
Naltrexone	Approved (phase 4)
Alcohol	Phase 3 (in late-stage trials)
Aripiprazole	Phase 3 (in late-stage trials)
Baclofen	Phase 3 (in late-stage trials)
Calcium Carbonate	Phase 3 (in late-stage trials)
Desipramine	Phase 3 (in late-stage trials)
Gabapentin	Phase 3 (in late-stage trials)
Hydrocortisone	Phase 3 (in late-stage trials)
Ketamine	Phase 3 (in late-stage trials)
Lemborexant	Phase 3 (in late-stage trials)
Levetiracetam	Phase 3 (in late-stage trials)
Lithium Carbonate	Phase 3 (in late-stage trials)
Olanzapine	Phase 3 (in late-stage trials)
Ondansetron	Phase 3 (in late-stage trials)
Oxytocin	Phase 3 (in late-stage trials)
Paroxetine	Phase 3 (in late-stage trials)
Prazosin	Phase 3 (in late-stage trials)
Sodium Chloride	Phase 3 (in late-stage trials)
Topiramate	Phase 3 (in late-stage trials)
Valproic Acid	Phase 3 (in late-stage trials)
Varenicline	Phase 3 (in late-stage trials)
Zonisamide	Phase 3 (in late-stage trials)

Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Acetylcysteine, Apomorphine, Apremilast, Aprepitant, Arbaclofen Placarbil, Atomoxetine, Brexpiprazole, Bupropion, Cannabidiol, Citalopram, Citicoline, Cyproheptadine, Diphenhydramine, Doxazosin, Duloxetine, Exenatide, Fenofibrate, Fenofibric Acid, Flumazenil, Gabapentin Enacarbil, Gemfibrozil, Guanfacine, Ibudilast, Lacosamide, Lamotrigine, Lorazepam, Maltodextrin, Mecamylamine, Memantine, Mifepristone, Mirtazapine, Modafinil, Pioglitazone, Pitolisant, Pregabalin, Pregnenolone Succinate, Psilocybin, Quetiapine, Samidorphan, Semaglutide, Sertraline, Suvorexant, Tolcapone, Tradipitant, Trazodone, Vigabatrin, Yohimbine.

Clinical trials & evidence

Clinical trials

Clinical trials: 822.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	415
PHASE2	147
PHASE4	102
PHASE3	66
PHASE1	44
PHASE2/PHASE3	22
PHASE1/PHASE2	17
EARLY_PHASE1	9

Top trials by phase / activity

NCT	Phase	Status	Title
NCT05028062	PHASE4	RECRUITING	Naltrexone in AUD Reward Drinkers
NCT00000437	PHASE4	COMPLETED	Tobacco Dependence in Alcoholism Treatment (Nicotine Patch/Naltrexone)
NCT00000438	PHASE4	COMPLETED	Naltrexone Treatment for Alcoholism
NCT00000441	PHASE4	COMPLETED	Drug Therapy for Alcohol Detoxification
NCT00000442	PHASE4	COMPLETED	Naltrexone for Relapse Prevention
NCT00000444	PHASE4	COMPLETED	Timing of Smoking Intervention in Alcohol Treatment (Nicotine Patch)
NCT00000445	PHASE4	COMPLETED	Use of Naltrexone in a Clinical Setting
NCT00000447	PHASE4	COMPLETED	Behavioral/Drug Therapy for Alcohol-Nicotine Dependence (Naltrexone/Nicotine Patch)
NCT00000448	PHASE4	COMPLETED	Naltrexone Treatment for Alcoholic Women
NCT00000449	PHASE4	COMPLETED	Behavior and Naltrexone Treatment for Alcoholics
NCT00000450	PHASE4	COMPLETED	Naltrexone Maintenance Treatment of Alcoholism
NCT00000452	PHASE4	COMPLETED	Naltrexone Treatment of Alcohol Dependence
NCT00000454	PHASE4	COMPLETED	Smoking Cessation in Alcoholism Treatment
NCT00000455	PHASE4	COMPLETED	Naltrexone for Early Problem Drinkers
NCT00000456	PHASE4	COMPLETED	Behavioral Therapy Plus Naltrexone for Alcoholism
NCT00004551	PHASE4	COMPLETED	Behavioral Counseling for Alcohol Dependent Smokers (Nicotine Patch)
NCT00004554	PHASE4	COMPLETED	Sertraline for Alcohol Dependence and Depression
NCT00006203	PHASE4	COMPLETED	Naltrexone, Craving, and Drinking
NCT00006204	PHASE4	COMPLETED	Drug Treatment for Depressed Alcoholics (Naltrexone/Fluoxetine)
NCT00006449	PHASE4	COMPLETED	Post-Treatment Effects of Naltrexone
NCT00006489	PHASE4	COMPLETED	Treatment for Alcoholism and Post-Traumatic Stress Disorder (Naltrexone)
NCT00018824	PHASE4	COMPLETED	Treating Alcohol Use In Older Adults With Depression
NCT00044434	PHASE4	COMPLETED	Bupropion as a Smoking Cessation Aid in Alcoholics
NCT00064844	PHASE4	COMPLETED	Combination Nicotine Replacement for Alcoholic Smokers
NCT00082199	PHASE4	COMPLETED	Study of Aripiprazole in Subjects With Alcoholism
NCT00115037	PHASE4	COMPLETED	Managing Alcoholism in People Who Do Not Respond to Naltrexone
NCT00120601	PHASE4	UNKNOWN	Trial for the Treatment of Alcohol Dependence
NCT00130923	PHASE4	COMPLETED	Risperidone Long-acting Versus Oral Risperidone in Patients With Schizophrenia and Alcohol Use Disorder
NCT00145847	PHASE4	COMPLETED	Naltrexone Treatment of Alcohol Abuse in Schizophrenia
NCT00148031	PHASE4	COMPLETED	Improving Hepatitis C Treatment in Injection Drug Users
NCT00156715	PHASE4	COMPLETED	Efficacy of Quetiapine in the Treatment of Patients With Schizophrenia and a Comorbid Substance Use Disorder
NCT00159107	PHASE4	COMPLETED	Integrative Therapy in Alcoholism
NCT00167687	PHASE4	COMPLETED	Prazosin Alcohol Dependence IVR Study
NCT00169026	PHASE4	TERMINATED	Alcoholism and Schizophrenia: Effects of Clozapine
NCT00223249	PHASE4	COMPLETED	Quetiapine in Patients With Bipolar and Alcohol Abuse/Dependence
NCT00223275	PHASE4	COMPLETED	Naltrexone for Bipolar Disorder and Alcohol Dependence
NCT00226109	PHASE4	SUSPENDED	Clinical Trial Studying the Effects of Spironolactone on Heart and Skeletal Muscle Function in Chronic Alcoholics
NCT00246441	PHASE4	COMPLETED	Paroxetine for Comorbid Social Anxiety Disorder and Alcoholism
NCT00249379	PHASE4	TERMINATED	Study of Acamprosate to Prevent Alcohol Relapse in Criminal Justice Supervisees
NCT00261872	PHASE4	COMPLETED	Treatment of Patients With Alcoholism and Attention Deficit Disorder

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
NALTREXONE	4	158
ACAMPROSATE	4	22
PRAZOSIN	4	21
NALMEFENE	4	13
BACLOFEN	4	12
QUETIAPINE	4	11
FLUOXETINE	4	9
VALPROIC ACID	4	8
TOPIRAMATE	4	7
BUPROPION	4	6
DOXAZOSIN	4	6
MECAMYLAMINE	4	6
ONDANSETRON	4	6
VARENICLINE	4	6
ZONISAMIDE	4	6
ALCOHOL	4	4
DISULFIRAM	4	4
DUTASTERIDE	4	4
PAROXETINE	4	4
LORAZEPAM	4	3
APREPITANT	4	2
DESIPRAMINE	4	2
ESCITALOPRAM	4	2
LAMOTRIGINE	4	2
LEVETIRACETAM	4	2
MIRTAZAPINE	4	2
NIACIN	4	2
SERTRALINE	4	2
ACETYLCYSTEINE	4	1
APOMORPHINE	4	1