Amniotic fluid embolism

Summary

Amniotic fluid embolism (MONDO:0850046) is a disease and 4 clinical trials. A subtype of pregnancy disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (United Kingdom) [Orphanet-validated]
• Clinical trials: 4

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	amniotic fluid embolism
Mondo ID	MONDO:0850046
Orphanet	617304
ICD-11	1017418792
UMLS	C0013927
MedGen	8586
GARD	0022448
Is cancer (heuristic)	no

Disease family

This is a subtype of pregnancy disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by developmental or physiological process › obstetric disorder › pregnancy disorder › amniotic fluid embolism

Related subtypes (28): funisitis, chorea gravidarum, luteoma of pregnancy, polyhydramnios, impetigo herpetiformis, gestational diabetes, placenta disorder, pemphigoid gestationis, dystocia, hyperemesis gravidarum, pruritic urticarial papules and plaques of pregnancy, familial gestational hyperthyroidism, pseudohyperaldosteronism type 2, aromatase deficiency, acute fatty liver of pregnancy, malignancy diagnosed during pregnancy, postpartum psychosis, peripartum cardiomyopathy, gestational trophoblastic neoplasm, hypertension, pregnancy-induced, chronic intervillositis of unknown etiology, pregnancy disorder with abortive outcome, postpartum amenorrhea-galactorrhea syndrome, pregnancy associated osteoporosis, twin anemia-polycythemia sequence, twin-reversed arterial perfusion sequence, selective intrauterine growth restriction, vasa previa

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 4.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	4

Top trials by phase / activity

NCT	Phase	Status	Title
NCT05791786	Not specified	RECRUITING	The Establishment of a Registry and a Biorepository of Patients With Suspected Amniotic Fluid Embolism (AFE)
NCT06991985	Not specified	NOT_YET_RECRUITING	Analysis of Factors Associated With The Occurrence of Amniotic Fluid Entry in Patients Undergoing Caesarean Section
NCT04256083	Not specified	COMPLETED	Metabolomic and Proteomic Profiles of Amniotic Fluid Embolism
NCT06254092	Not specified	UNKNOWN	Effect of Tourniquet Binding of Cervical on the Blood Volume of Amniotic Fluid in Cesarean Section