Ampulla of vater cancer

Summary

Ampulla of vater cancer (MONDO:0000919) is a cancer and 11 clinical trials. Top therapeutic interventions include bevacizumab, dalteparin sodium, and adh-1. A subtype of duodenum cancer — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Clinical trials: 11

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	ampulla of vater cancer
Mondo ID	MONDO:0000919
DOID	DOID:10020
ICD-10-CM	C24.1
NCIT	C3536
SNOMED CT	363417006
UMLS	C0153454
MedGen	57785
GARD	0022845
Anatomy (UBERON)	UBERON:0004913
Is cancer (heuristic)	yes

Also known as: cancer of hepatopancreatic ampulla · hepatopancreatic ampulla cancer · malignant ampulla of Vater neoplasm · malignant ampulla of Vater tumor · malignant ampulla of Vater tumour · malignant hepatopancreatic ampulla neoplasm · malignant neoplasm of ampulla of Vater · malignant neoplasm of hepatopancreatic ampulla · malignant neoplasm of the ampulla of Vater · malignant tumor of ampulla of Vater · malignant tumor of ampulla of vater · malignant tumor of the ampulla of Vater · malignant tumour of the ampulla of Vater

Disease family

This is a subtype of duodenum cancer. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › digestive system disorder › intestinal disorder › intestinal neoplasm › small intestine neoplasm › small intestine cancer › duodenum cancer › ampulla of vater cancer

Related subtypes (1): carcinoma of duodenum

Subtypes (1): carcinoma of the ampulla of vater

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 11.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	6
PHASE2	2
PHASE1	2
PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00809081	PHASE3	UNKNOWN	Early Enteral Feeding After Pylorus Preserving Pancreatoduodenectomy
NCT01208103	PHASE2	COMPLETED	Bevacizumab, Capecitabine, and Oxaliplatin in Treating Advanced Small Intestinal or Ampulla of Vater Adenocarcinoma
NCT03139487	PHASE2	UNKNOWN	A Randomized Phase II Open Label Study to Compare the Safety and Efficacy of Subcutaneous Dalteparin Versus Direct Oral Anticoagulants for Cancer-associated Venous Thromboembolism
NCT01825603	PHASE1	COMPLETED	ADH-1, Gemcitabine Hydrochloride & Cisplatin in Treating Metastatic Pancreatic or Biliary Tract Cancer
NCT02333188	PHASE1	COMPLETED	Genetic Analysis-Guided Dosing of FOLFIRABRAX in Treating Patients With Advanced Gastrointestinal Cancer
NCT07199127	Not specified	RECRUITING	Duodenal Polyposis Classification in FAP
NCT01134276	Not specified	COMPLETED	Comparison Between Internal and External Preoperative Biliary Drainage in Periampullary Cancers
NCT03150615	Not specified	COMPLETED	Enteral Nutrition After Pancreaticoduodenectomy
NCT03494023	Not specified	COMPLETED	EUS Evaluation of CBD Diameter in Malignant Obstructive Jaundice
NCT04763642	Not specified	COMPLETED	The Comparison of Miniinvasive and Open Pancreaticoduodenectomy for Cancer Pancreaticobiliary Zone
NCT05690412	Not specified	UNKNOWN	Efficacy and Safety of Endoscopic Papillectomy in the Treatment of Ampullary Neoplasms.

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
BEVACIZUMAB	4	1
DALTEPARIN SODIUM	4	1
ADH-1	1	1