Amyotrophic lateral sclerosis type 1

Summary

Amyotrophic lateral sclerosis type 1 (MONDO:0007103) is a disease caused by variants in DCTN1 and SOD1, with 9 cohort genes and 5 clinical trials.

At a glance

• Causal genes: DCTN1 (GenCC Strong), SOD1 (GenCC Strong)
• Cohort genes: 9
• ClinVar variants: 1,626
• Clinical trials: 5

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	amyotrophic lateral sclerosis type 1
Mondo ID	MONDO:0007103
MeSH	C531617
OMIM	105400
DOID	DOID:0060193
UMLS	C1862939
MedGen	400169
GARD	0024523
Is cancer (heuristic)	no

Also known as: ALS1 · amyotrophic lateral sclerosis 1 · amyotrophic lateral sclerosis 1, autosomal dominant amyotrophic lateral sclerosis 1, autosomal recessive, included · amyotrophic lateral sclerosis 1, familial · amyotrophic lateral sclerosis type 1 · amyotrophic lateral sclerosis, autosomal dominant · amyotrophic lateral sclerosis, familial · amyotrophic lateral sclerosis, sporadic · amyotrophic lateral sclerosis, sporadic, included · FALS

Data availability: 1,626 ClinVar variants · 8 GenCC gene-disease records · 94 cell lines.

Disease family

Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › spinal cord disorder › anterior horn disorder › amyotrophic lateral sclerosis › familial amyotrophic lateral sclerosis › amyotrophic lateral sclerosis type 1

Related subtypes (29): frontotemporal dementia and/or amyotrophic lateral sclerosis 1, spinocerebellar ataxia type 2, amyotrophic lateral sclerosis type 15, frontotemporal dementia and/or amyotrophic lateral sclerosis 7, amyotrophic lateral sclerosis type 4, amyotrophic lateral sclerosis type 21, amyotrophic lateral sclerosis type 3, amyotrophic lateral sclerosis type 6, amyotrophic lateral sclerosis type 7, amyotrophic lateral sclerosis type 8, amyotrophic lateral sclerosis type 9, amyotrophic lateral sclerosis type 10, amyotrophic lateral sclerosis type 11, amyotrophic lateral sclerosis type 12, frontotemporal dementia and/or amyotrophic lateral sclerosis 6, amyotrophic lateral sclerosis type 18, amyotrophic lateral sclerosis type 20, amyotrophic lateral sclerosis type 19, frontotemporal dementia and/or amyotrophic lateral sclerosis 2, amyotrophic lateral sclerosis type 22, frontotemporal dementia and/or amyotrophic lateral sclerosis 3, frontotemporal dementia and/or amyotrophic lateral sclerosis 4, juvenile amyotrophic lateral sclerosis, amyotrophic lateral sclerosis type 23, frontotemporal dementia and/or amyotrophic lateral sclerosis 8, frontotemporal dementia and/or amyotrophic lateral sclerosis 5, amyotrophic lateral sclerosis 26 with or without frontotemporal dementia, amyotrophic lateral sclerosis 27, juvenile, amyotrophic lateral sclerosis 28

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

ClinVar germline variants

600 retrieved; paginated sample, class counts are floors:

251 likely benign, 243 uncertain significance, 34 pathogenic, 27 conflicting classifications of pathogenicity, 17 likely pathogenic, 13 pathogenic/likely pathogenic, 8 benign/likely benign, 7 benign

ClinVar	Variant (HGVS)	Gene	Classification	Review
1458171	NM_004082.5(DCTN1):c.175G>C (p.Gly59Arg)	DCTN1	Pathogenic	criteria provided, single submitter
1929273	NM_004082.5(DCTN1):c.626dup (p.Leu210fs)	DCTN1	Pathogenic	criteria provided, single submitter
1018905	NM_000454.5(SOD1):c.143T>C (p.Val48Ala)	SOD1	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
1030809	NM_000454.5(SOD1):c.230A>T (p.Asp77Val)	SOD1	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
1066874	NM_000454.5(SOD1):c.304G>C (p.Asp102His)	SOD1	Pathogenic	criteria provided, single submitter
1067619	NM_000454.5(SOD1):c.374A>T (p.Asp125Val)	SOD1	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
1072003	NM_000454.5(SOD1):c.281G>A (p.Gly94Asp)	SOD1	Pathogenic	criteria provided, multiple submitters, no conflicts
1163753	NM_000454.5(SOD1):c.413C>T (p.Thr138Ile)	SOD1	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
1191297	NM_000454.5(SOD1):c.269C>T (p.Ala90Val)	SOD1	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
1212596	NM_000454.5(SOD1):c.374A>G (p.Asp125Gly)	SOD1	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
1455194	NM_000454.5(SOD1):c.449T>C (p.Ile150Thr)	SOD1	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
14752	NM_000454.5(SOD1):c.112G>A (p.Gly38Arg)	SOD1	Pathogenic	criteria provided, multiple submitters, no conflicts
14753	NM_000454.5(SOD1):c.115C>G (p.Leu39Val)	SOD1	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
14754	NM_000454.5(SOD1):c.124G>A (p.Gly42Ser)	SOD1	Pathogenic	criteria provided, multiple submitters, no conflicts
14755	NM_000454.5(SOD1):c.125G>A (p.Gly42Asp)	SOD1	Pathogenic	criteria provided, multiple submitters, no conflicts
14756	NM_000454.5(SOD1):c.131A>G (p.His44Arg)	SOD1	Pathogenic	criteria provided, multiple submitters, no conflicts
14757	NM_000454.5(SOD1):c.319C>G (p.Leu107Val)	SOD1	Pathogenic	criteria provided, multiple submitters, no conflicts
14758	NM_000454.5(SOD1):c.256G>C (p.Gly86Arg)	SOD1	Pathogenic	criteria provided, multiple submitters, no conflicts
14759	NM_000454.5(SOD1):c.280G>T (p.Gly94Cys)	SOD1	Pathogenic	criteria provided, single submitter
14760	NM_000454.5(SOD1):c.281G>C (p.Gly94Ala)	SOD1	Pathogenic	criteria provided, single submitter
14761	NM_000454.5(SOD1):c.302A>G (p.Glu101Gly)	SOD1	Pathogenic	criteria provided, multiple submitters, no conflicts
14762	NM_000454.5(SOD1):c.338T>C (p.Ile113Thr)	SOD1	Pathogenic	criteria provided, single submitter
14764	NM_000454.5(SOD1):c.140A>G (p.His47Arg)	SOD1	Pathogenic	criteria provided, multiple submitters, no conflicts
14765	NM_000454.5(SOD1):c.13G>A (p.Ala5Thr)	SOD1	Pathogenic	criteria provided, multiple submitters, no conflicts
14768	NM_000454.5(SOD1):c.434T>C (p.Leu145Ser)	SOD1	Pathogenic	criteria provided, multiple submitters, no conflicts
14769	NM_000454.5(SOD1):c.436G>A (p.Ala146Thr)	SOD1	Pathogenic	criteria provided, single submitter
14770	NM_000454.5(SOD1):c.358-10T>G	SOD1	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts
14771	NM_000454.5(SOD1):c.20G>T (p.Cys7Phe)	SOD1	Pathogenic	no assertion criteria provided
14772	NM_000454.5(SOD1):c.455T>C (p.Ile152Thr)	SOD1	Pathogenic	no assertion criteria provided
14773	NM_000454.5(SOD1):c.64G>A (p.Glu22Lys)	SOD1	Pathogenic	no assertion criteria provided

Genes & proteins

Mendelian disease overlap and somatic drivers

GenCC: 22 · Orphanet: 8 · OMIM-shared: 0 · Dual-evidence (GWAS+Mendelian): 0

GenCC gene–disease validity (cohort genes)

the Disease column is the GenCC-asserted condition — a cohort gene’s strongest validity may be for a related predisposition syndrome.

Gene	Classification	Inheritance	Disease	Records
DCTN1	Strong	Autosomal dominant	amyotrophic lateral sclerosis type 1	12
SOD1	Strong	Autosomal dominant	amyotrophic lateral sclerosis type 1	6
PRPH	Moderate	Autosomal dominant	amyotrophic lateral sclerosis type 1	4

Orphanet rare-disease linkage (cohort genes)

Gene	Orphanet ID	Rare disease
SOD1	Orphanet:803	Amyotrophic lateral sclerosis
DCTN1	Orphanet:139589	Distal hereditary motor neuropathy type 7
DCTN1	Orphanet:178509	Perry syndrome
DCTN1	Orphanet:803	Amyotrophic lateral sclerosis
PRPH	Orphanet:803	Amyotrophic lateral sclerosis
SCAF4	Orphanet:528084	Non-specific syndromic intellectual disability
UNC13A	Orphanet:803	Amyotrophic lateral sclerosis
NEFH	Orphanet:803	Amyotrophic lateral sclerosis

Cohort genes → proteins

9 cohort genes, 7 distinct canonical proteins.

Evidence partition

Subset	Genes
multi_evidence	9

Cohort genes (full)

Symbol	HGNC	Ensembl	UniProt	Name	Evidence
SOD1	HGNC:11179	ENSG00000142168	P00441	Superoxide dismutase [Cu-Zn]	gencc,clinvar
DCTN1	HGNC:2711	ENSG00000204843	Q14203	Dynactin subunit 1	gencc,clinvar
PRPH	HGNC:9461	ENSG00000135406	P41219	Peripherin	gencc,clinvar
SCAF4	HGNC:19304	ENSG00000156304	O95104	SR-related and CTD-associated factor 4	clinvar
UNC13A	HGNC:23150	ENSG00000130477	Q9UPW8	Protein unc-13 homolog A	clinvar
TROAP-AS1	HGNC:55453	ENSG00000258334		TROAP and PRPH antisense RNA 1	clinvar
SOD1-DT	HGNC:55683	ENSG00000234509		SOD1 divergent transcript	clinvar
NEFH	HGNC:7737	ENSG00000100285	P12036	Neurofilament heavy polypeptide	clinvar
ATP5PO	HGNC:850	ENSG00000241837	P48047	ATP synthase peripheral stalk subunit OSCP, mitochondrial	clinvar

Cohort function summary

Lead sentence per gene, UniProt-curated.

Symbol	Protein name	Function (lead sentence)
SOD1	Superoxide dismutase [Cu-Zn]	Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
DCTN1	Dynactin subunit 1	Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
PRPH	Peripherin	Class-III neuronal intermediate filament protein.
SCAF4	SR-related and CTD-associated factor 4	Anti-terminator protein required to prevent early mRNA termination during transcription.
UNC13A	Protein unc-13 homolog A	Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway.
NEFH	Neurofilament heavy polypeptide	Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber.
ATP5PO	ATP synthase peripheral stalk subunit OSCP, mitochondrial	Subunit OSCP, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of…

Protein-family classification

Druggable: 1 · Difficult: 0 · Unknown: 8 · Druggable fraction: 0.11

Family distribution

Cohort families vs a genome-wide background (hypergeometric, BH-FDR; fold = observed/expected). Counts kept; sorted by enrichment, so the catch-all Other/Unknown bucket no longer leads.

Family	Genes	Fold	FDR
Other/Unknown	8	1.6×	0.085
Enzyme (other)	1	1.3×	0.543

Per-gene assignment

Symbol	Family	Druggable?	EC	InterPro (top 3)
SOD1	Enzyme (other)	yes	1.15.1.1	SOD_Cu_Zn_dom, SOD_Cu/Zn_BS, SOD_Cu/Zn_/chaperone
DCTN1	Other/Unknown	no		CAP-Gly_domain, Dynactin, CAP-Gly_dom_sf
PRPH	Other/Unknown	no		Keratin_I, Intermed_filament_DNA-bd, IF_conserved
SCAF4	Other/Unknown	no		RRM_dom, CID_dom, ENTH_VHS
UNC13A	Other/Unknown	no		C2_dom, PKC_DAG/PE, MUN_dom
TROAP-AS1	Other/Unknown	no
SOD1-DT	Other/Unknown	no
NEFH	Other/Unknown	no		DUF1388, IF_conserved, IF_rod_dom
ATP5PO	Other/Unknown	no		ATPase_OSCP/dsu, ATPase_OSCP/d_CS, ATP_synth_OSCP/delta_N_sf

Expression context

Cohort genes with no expression data: 0.

7 cohort genes are a single-cell marker in ≥1 SCXA experiment.

Breadth distribution (Bgee present_calls)

Bucket	Genes
narrow (1-5 tissues)	0
moderate (6-20)	0
broad (>20)	9
unknown	0

Top tissues across cohort

Tissue	Cohort genes
dorsal root ganglion	3
pons	2
right hemisphere of cerebellum	2
sperm	2
buccal mucosa cell	2
substantia nigra pars compacta	1
prefrontal cortex	1
right frontal lobe	1
trigeminal ganglion	1
tendon of biceps brachii	1
cerebellar cortex	1
cerebellar hemisphere	1
fallopian tube	1
olfactory segment of nasal mucosa	1
right uterine tube	1
male germ line stem cell (sensu Vertebrata) in testis	1
primordial germ cell in gonad	1
lateral nuclear group of thalamus	1
apex of heart	1
heart left ventricle	1

Per-gene tissue summary (top 30)

Symbol	Bgee breadth	FANTOM5 breadth	SCXA	Top tissues
SOD1	304	ubiquitous	marker	pons, dorsal root ganglion, substantia nigra pars compacta
DCTN1	275	ubiquitous	marker	right frontal lobe, prefrontal cortex, right hemisphere of cerebellum
PRPH	178	broad	marker	dorsal root ganglion, trigeminal ganglion, sperm
SCAF4	267	ubiquitous	marker	tendon of biceps brachii, buccal mucosa cell, sperm
UNC13A	193	broad	marker	right hemisphere of cerebellum, cerebellar hemisphere, cerebellar cortex
TROAP-AS1	78		yes	right uterine tube, olfactory segment of nasal mucosa, fallopian tube
SOD1-DT	97		yes	male germ line stem cell (sensu Vertebrata) in testis, buccal mucosa cell, primordial germ cell in gonad
NEFH	222	broad	marker	dorsal root ganglion, pons, lateral nuclear group of thalamus
ATP5PO	149	ubiquitous	marker	heart left ventricle, apex of heart, right atrium auricular region

Protein interactions among cohort

Intra-cohort edges: 2.

Hub genes (top 10 by interactor count)

Symbol	Interactor count
SOD1	6,807
ATP5PO	3,811
DCTN1	3,654
NEFH	2,649
SCAF4	2,068
UNC13A	1,621
PRPH	784
TROAP-AS1	0
SOD1-DT	0

Intra-cohort edges

A	B	Sources
DCTN1	NEFH	string_interaction
NEFH	SOD1	string_interaction

Structural data

PDB: 4 · AlphaFold-only: 3 · No structure: 2

Cohort genes with PDB structures (top 30)

Symbol	UniProt	PDB entries
SOD1	P00441	156
DCTN1	Q14203	13
ATP5PO	P48047	9
SCAF4	O95104	1

AlphaFold-only cohort genes (top 30 by pLDDT)

Symbol	UniProt	pLDDT
PRPH	P41219	79.24
UNC13A	Q9UPW8	73.58
NEFH	P12036	54.28

Function

Pathway analysis

Distinct Reactome pathways touched by cohort: 35. Enrichment computed across 9 evidence-associated genes (3 with Reactome annotation).

Pathways by enrichment

Over-representation of cohort genes vs the genome-wide background (hypergeometric test, Benjamini-Hochberg FDR; fold = observed/expected over 3 annotated cohort genes). Counts and members are kept as ground-truth; sorted by enrichment.

Pathway	Cohort genes	Fold	FDR	Sample cohort genes
Formation of ATP by chemiosmotic coupling	1	190.3×	0.043	ATP5PO
Interleukin-12 family signaling	1	158.6×	0.043	SOD1
Interleukin-12 signaling	1	135.9×	0.043	SOD1
Cristae formation	1	115.3×	0.043	ATP5PO
Detoxification of Reactive Oxygen Species	1	100.2×	0.043	SOD1
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	1	100.2×	0.043	SOD1
XBP1(S) activates chaperone genes	1	71.8×	0.043	DCTN1
COPI-independent Golgi-to-ER retrograde traffic	1	69.2×	0.043	DCTN1
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	1	64.5×	0.043	DCTN1
Mitochondrial biogenesis	1	56.0×	0.043	ATP5PO
Response to elevated platelet cytosolic Ca2+	1	54.4×	0.043	SOD1
Loss of Nlp from mitotic centrosomes	1	52.9×	0.043	DCTN1
Loss of proteins required for interphase microtubule organization from the centrosome	1	52.9×	0.043	DCTN1
AURKA Activation by TPX2	1	50.8×	0.043	DCTN1
Signaling by ALK fusions and activated point mutants	1	50.1×	0.043	DCTN1
Cellular response to chemical stress	1	47.6×	0.043	SOD1
Recruitment of mitotic centrosome proteins and complexes	1	45.3×	0.043	DCTN1
Regulation of PLK1 Activity at G2/M Transition	1	42.3×	0.043	DCTN1
Recruitment of NuMA to mitotic centrosomes	1	38.8×	0.043	DCTN1
Mitochondrial protein degradation	1	38.1×	0.043	ATP5PO
Anchoring of the basal body to the plasma membrane	1	37.7×	0.043	DCTN1
COPI-mediated anterograde transport	1	36.6×	0.043	DCTN1
Platelet activation, signaling and aggregation	1	35.2×	0.043	SOD1
MHC class II antigen presentation	1	29.7×	0.045	DCTN1
Aerobic respiration and respiratory electron transport	1	29.5×	0.045	ATP5PO
Platelet degranulation	1	29.3×	0.045	SOD1
Organelle biogenesis and maintenance	1	22.0×	0.058	ATP5PO
Signaling by Interleukins	1	21.4×	0.058	SOD1
Cytokine Signaling in Immune system	1	13.6×	0.087	SOD1
Cellular responses to stress	1	12.3×	0.091	SOD1

GO biological processes by enrichment

Over-representation of cohort genes vs the genome-wide background (hypergeometric test, Benjamini-Hochberg FDR; fold = observed/expected over 7 annotated cohort genes). Counts and members are kept as ground-truth; sorted by enrichment.

GO term	Cohort genes	Fold	FDR	Sample cohort genes
neurofilament cytoskeleton organization	2	481.5×	7e-04	SOD1, NEFH
response to antipsychotic drug	1	1203.7×	0.015	SOD1
neuronal dense core vesicle exocytosis	1	1203.7×	0.015	UNC13A
positive regulation of neuromuscular junction development	1	1203.7×	0.015	DCTN1
negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled	1	1203.7×	0.015	SCAF4
neurofilament bundle assembly	1	802.5×	0.015	NEFH
response to carbon monoxide	1	802.5×	0.015	SOD1
dense core granule priming	1	802.5×	0.015	UNC13A
action potential initiation	1	802.5×	0.015	SOD1
peripheral nervous system neuron axonogenesis	1	601.9×	0.017	NEFH
regulation of organelle transport along microtubule	1	601.9×	0.017	NEFH
response to superoxide	1	481.5×	0.018	SOD1
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	1	481.5×	0.018	SOD1
intermediate filament bundle assembly	1	401.2×	0.018	NEFH
relaxation of vascular associated smooth muscle	1	401.2×	0.018	SOD1
regulation of T cell differentiation in thymus	1	343.9×	0.019	SOD1
myeloid cell homeostasis	1	300.9×	0.019	SOD1
regulation of organ growth	1	300.9×	0.019	SOD1
positive regulation of microtubule nucleation	1	300.9×	0.019	DCTN1
mitotic nuclear membrane disassembly	1	267.5×	0.019	DCTN1
ventral spinal cord development	1	267.5×	0.019	DCTN1
negative regulation of developmental process	1	267.5×	0.019	SOD1
negative regulation of reproductive process	1	240.7×	0.019	SOD1
retrograde axonal transport	1	218.9×	0.019	SOD1
peripheral nervous system myelin maintenance	1	218.9×	0.019	SOD1
response to copper ion	1	218.9×	0.019	SOD1
maintenance of synapse structure	1	218.9×	0.019	DCTN1
microtubule anchoring at centrosome	1	200.6×	0.019	DCTN1
hydrogen peroxide biosynthetic process	1	200.6×	0.019	SOD1
centriole-centriole cohesion	1	185.2×	0.019	DCTN1

Therapeutics

Drug target analysis

Approved (phase 4): 0 · Phase ≥3: 0 · Phased (≥1): 0 · Undrugged: 9

Druggability breadth: 4 of 9 evidence-associated genes (44%) have a ChEMBL target (buckets above are over the deeply-mined display cohort).

Top cohort targets by molecule count

Symbol	Molecules	Max phase
SOD1	0	0
DCTN1	0	0
PRPH	0	0
SCAF4	0	0
UNC13A	0	0
TROAP-AS1	0	0
SOD1-DT	0	0
NEFH	0	0
ATP5PO	0	0

Bioactivity and enzyme data

Enzyme cohort genes (≥1 EC): 1.

Cohort genes with ChEMBL bioactivity (full, sorted by assay count)

Symbol	Assays	Type breakdown
SOD1	38	Binding:32, Functional:5, ADMET:1
DCTN1	1	Binding:1
PRPH	1	Binding:1
ATP5PO	1	Binding:1

Cohort enzymes (BRENDA EC)

Symbol	EC numbers	Names
SOD1	1.15.1.1	superoxide dismutase

Pharmacogenomics

Cohort genes with a PharmGKB record: 7; with CPIC/DPWG dosing guidelines: 0.

No cohort gene has a CPIC/DPWG genotype-guided dosing guideline (PharmGKB).

Chemical tractability of cohort targets

0 approved/phased compounds have measured bioactivity against a cohort gene (and aren’t yet in disease-level trials). This is a research / tractability signal, NOT a therapeutic recommendation — a bioactivity row often reflects off-target or screening binding (e.g. promiscuous kinase inhibitors against a cohort kinase), implying no disease mechanism.

Druggability pyramid

Cohort genes binned by druggability tier (high → low):

Tier	Definition	Genes	Symbols
A	Approved (phase 4 drug)	0
B	Phased (≥1) drug, not yet approved	0
C	Druggable family + PDB, no drug	1	SOD1
D	Druggable family + AlphaFold only, no drug	0
E	Difficult family or no structure, no drug	8	DCTN1, PRPH, SCAF4, UNC13A, TROAP-AS1, SOD1-DT, NEFH, ATP5PO

Undrugged target profiles

9 cohort genes are undrugged. Ranked by ‘starting-point quality’ (assay depth + drugged-partner adjacency).

Symbol	ChEMBL assays	Drugged partners (top 3)
SOD1	38	—
DCTN1	1	—
PRPH	1	—
SCAF4	0	—
UNC13A	0	—
TROAP-AS1	0	—
SOD1-DT	0	—
NEFH	0	—
ATP5PO	1	—

Clinical trials & evidence

Clinical trials

Clinical trials: 5.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	4
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT03204500	PHASE2	COMPLETED	Dual Treatment With Lithium and Valproate in ALS.
NCT05928416	Not specified	ACTIVE_NOT_RECRUITING	ALS Diagnosis From a Saliva Sample: a Non-coding RNA Analysis Approach
NCT01459302	Not specified	WITHDRAWN	Genetic Study of Familial and Sporadic ALS/Motor Neuron Disease, Miyoshi Myopathy and Other Neuromuscular Disorders
NCT03449212	Not specified	SUSPENDED	SOD1 Kinetics Measurements in ALS Patients
NCT07170501	Not specified	COMPLETED	Postural Control as a Predictor of Disability, Fall-Related Fear, and Social Participation in Elderly Women With Non-Specific Low Back Pain