Anemia of prematurity

disease

On this page

Also known as AOP

Summary

Anemia of prematurity (MONDO:0001239) is a disease and 15 clinical trials. Top therapeutic interventions include ferrous sulfate. A subtype of neonatal anemia — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

Clinical trials: 15

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	anemia of prematurity
Mondo ID	MONDO:0001239
DOID	DOID:11243
ICD-10-CM	P61.2
NCIT	C97167
SNOMED CT	47100003
UMLS	C0158996
MedGen	472907
GARD	0022904
Is cancer (heuristic)	no

Also known as: AOP

Disease family

This is a subtype of neonatal anemia. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › hematologic disorder › anemia › neonatal anemia › anemia of prematurity

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 15.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	10
PHASE4	2
PHASE1	2
PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT01393496	PHASE4	COMPLETED	Effects of Transfusion Thresholds on Neurocognitive Outcome of Extremely Low Birth Weight Infants
NCT04497012	PHASE4	UNKNOWN	Iron Supplementation and Intestinal Health
NCT00182390	PHASE3	COMPLETED	Premature Infants in Need of Transfusion (PINT)
NCT00167388	PHASE1	COMPLETED	The Effect of Blood Transfusion on Blood Flow to the Intestines of Premature Infants
NCT01121328	PHASE1	WITHDRAWN	Autologous Umbilical Cord Blood Transfusion for Preterm Neonates
NCT06220461	Not specified	NOT_YET_RECRUITING	Folic Acid Supplementation to Reduce Anemia in Extremely Preterm Infants
NCT06555315	Not specified	RECRUITING	Pilot Trial Investigating Every Other Day Dosing of Oral Iron in Premature Infants (IQONic)
NCT00457990	Not specified	COMPLETED	Neurodevelopment After Early Iron Supplementation
NCT00458068	Not specified	COMPLETED	Early Versus Late Enteral Iron in Infants Less Than 1301 Grams
NCT01539356	Not specified	COMPLETED	Hepcidin Levels in Preterm Infants
NCT01735552	Not specified	TERMINATED	Transfusion-related Inflammatory Cytokine and Neutrophil Extracellular Trap Quantification in Neonates
NCT01735578	Not specified	COMPLETED	Splanchnic Tissue Oxygenation During Enteral Feedings in Anemic Premature Infants at Risk for Necrotizing Enterocolitis
NCT02101086	Not specified	COMPLETED	Autologous Cord Blood Transfusion in Preterm Infants
NCT02535208	Not specified	COMPLETED	Combining Restrictive Guidelines and a NIRS SCORE to Decrease RBC Transfusions
NCT04509375	Not specified	UNKNOWN	Near-Infrared Spectroscopy and Cranial Doppler in Premature Newborns With Anemia

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
FERROUS SULFATE	4	2

Drugs: Ferrous