Aneurysmal bone cyst

Summary

Aneurysmal bone cyst (MONDO:0018815) is a disease and 2 clinical trials. Top therapeutic interventions include denosumab. A subtype of bone neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 2

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	aneurysmal bone cyst
Mondo ID	MONDO:0018815
EFO	EFO:1001760
MeSH	D017824
OMIM	606179
Orphanet	480553
ICD-10-CM	M85.5
ICD-11	1603788294
NCIT	C3516
SNOMED CT	203468000
UMLS	C0152244
MedGen	57758
GARD	0021982
Is cancer (heuristic)	no

Also known as: ABC · aneurysmal bone cyst · aneurysmal bone cyst (disease) · aneurysmal bone cysts · aneurysmal cyst of bone · aneurysmal cyst of the bone

Data availability: 1 HPO phenotype.

Disease family

This is a subtype of bone neoplasm. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › bone disorder › bone neoplasm › aneurysmal bone cyst

Related subtypes (19): bone benign neoplasm, bone cancer, notochordal tumor, hereditary multiple osteochondromas, diaphyseal medullary stenosis-bone malignancy syndrome, hyperparathyroidism 1, hyperparathyroidism 2 with jaw tumors, OSLAM syndrome, Ollier disease, neonatal severe primary hyperparathyroidism, hyperparathyroidism 3, juvenile hyaline fibromatosis, solitary bone cyst, Ewing sarcoma/peripheral primitive neuroectodermal tumor of bone, neoplasm of femur, vascular bone neoplasm, hyperparathyroidism 4, skull neoplasm, congenital progressive bone marrow failure-B-cell immunodeficiency-skeletal dysplasia syndrome

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 2.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE1/PHASE2	1
PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT03066245	PHASE1/PHASE2	UNKNOWN	Use of Stem Cells Cultured on a Scaffold for the Treatment of Aneurysmal Bone Cysts (ABC)
NCT03605199	PHASE2	UNKNOWN	Denosumab in Subjects With Giant Cell Rich Tumors of Bone

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
DENOSUMAB	4	1