Angle-closure glaucoma

Summary

Angle-closure glaucoma (MONDO:0001744) is a disease and 15 clinical trials. Top therapeutic interventions include pilocarpine and travoprost. A subtype of glaucoma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 15

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	angle-closure glaucoma
Mondo ID	MONDO:0001744
MeSH	D015812
DOID	DOID:13550
SNOMED CT	392291006
UMLS	C0017605
MedGen	6610
Is cancer (heuristic)	no

Also known as: angle closure glaucoma

Data availability: 1 cell line.

Disease family

This is a subtype of glaucoma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › disorder of orbital region › eye disorder › glaucoma › angle-closure glaucoma

Related subtypes (10): glaucomatous atrophy of optic disk, hypersecretion glaucoma, aqueous misdirection, phacogenic glaucoma, traumatic glaucoma, borderline glaucoma, steroid-induced glaucoma, open-angle glaucoma, hereditary glaucoma, secondary early-onset glaucoma

Subtypes (2): primary angle-closure glaucoma, neovascular glaucoma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

2 approved. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Acetazolamide	Approved (phase 4)
Pilocarpine	Approved (phase 4)

Clinical trials & evidence

Clinical trials

Clinical trials: 15.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	13
PHASE4	1
PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00762645	PHASE4	COMPLETED	Travoprost 0.004% Versus Pilocarpine 1% in Patients With Chronic Angle Closure Glaucoma (CACG)
NCT00524758	PHASE3	COMPLETED	Oculusgen (Ologen) Glaucoma MMC Control in Estonia
NCT05563623	Not specified	RECRUITING	The Beijing Angle Closure Progression Study
NCT06492538	Not specified	RECRUITING	Biometric Changes After Intervention of Anterior Chamber Angle : an Observational Study
NCT07195370	Not specified	ACTIVE_NOT_RECRUITING	Testing YAG Laser Iridotomy for Primary Angle-Closure Glaucoma
NCT00350428	Not specified	COMPLETED	Laser Iridotomy Versus Phacoemulsification in Acute Angle Closure
NCT01895686	Not specified	COMPLETED	Comparison of Gonioscopy With Cirrus and Visante
NCT02199158	Not specified	COMPLETED	Short-term Outcomes of Iridoplasty for Persistent Angle Closure Despite Patent Iridotomies
NCT02474238	Not specified	COMPLETED	Comparing Nd:YAG Laser and Sequential Double Frequency YAG-Nd:YAG Laser Iridotomy
NCT03626675	Not specified	UNKNOWN	Anterior Segment Changes by Optical Coherence Tomography (OCT) in Phaco- Trabeculectomy
NCT04242108	Not specified	UNKNOWN	Diagnostic Performance of Deep Learning for Angle Closure
NCT04476810	Not specified	COMPLETED	Long Term Outcome of Combined Phacoemulsification and Excisional Goniotomy With the Kahook Dual Blade
NCT05163093	Not specified	UNKNOWN	Research on the Diagnosis and Treatment of Angle Closure Glaucoma With Abnormal Lens Zonular
NCT05543889	Not specified	UNKNOWN	Evaluation of Clinical Decisions and Assessment of Those at Risk of Primary Angle Closure by Community Optometrists
NCT05576493	Not specified	UNKNOWN	Combined Phacoemulsification and Diode Laser Therapy in Chronic Angle Closure Glaucoma

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
PILOCARPINE	4	1
TRAVOPROST	4	1