Anismus

Summary

Anismus (MONDO:0000480) is a disease and 7 clinical trials. A subtype of focal dystonia — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 7

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	anismus
Mondo ID	MONDO:0000480
DOID	DOID:0050839
SNOMED CT	83605009
UMLS	C0267601
MedGen	540810
Anatomy (UBERON)	UBERON:0004832
Is cancer (heuristic)	no

Also known as: anal region skeletal muscle focal dystonia · dyskinetic puborectalis · dyssynergic defecation · focal dystonia of anal region skeletal muscle · puborectalis syndrome

Disease family

This is a subtype of focal dystonia. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › movement disorder › extrapyramidal and movement disease › dystonic disorder › focal dystonia › anismus

Related subtypes (11): cervical dystonia, focal hand dystonia, oculogyric crisis, spasmodic dystonia, craniofacial dystonia, X-linked dystonia-parkinsonism, torsion dystonia 7, benign essential blepharospasm, dystonia 23, oromandibular dystonia, dystonia, focal, task-specific

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 7.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	6
PHASE4	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00556283	PHASE4	COMPLETED	RCT: STARR vs Biofeedback
NCT05771597	Not specified	RECRUITING	Home Biofeedback Therapy for Dyssynergic Defecation, Fecal Incontinence and Urinary Incontinence
NCT07225803	Not specified	RECRUITING	Management of Dyssynergic Defecation
NCT00735605	Not specified	COMPLETED	Comparative Study Between Surgical and Non Surgical Treatment of Anismus in Patients
NCT02633592	Not specified	COMPLETED	Seated Evaluation of Anorectal funcTion by High Resolution Anorectal Manometry
NCT04155307	Not specified	COMPLETED	Is the Evaluation of Anal Distensibility by Endoflip® Technique Useful for the Diagnosis of Anismus?
NCT04879524	Not specified	COMPLETED	Infracoccygeal Botox for Dyssynergia