Ankle injury
diseaseOn this page
Also known as ankle sprainankle SprainsInjuries, ankleInjuries, syndesmoticinjury of ankleinjury of tarsal regioninjury, ankleinjury, syndesmoticsprain, ankleSprains, anklesyndesmotic Injuriessyndesmotic injurytarsal region injury
Summary
Ankle injury (MONDO:0043895) is a disease and 268 clinical trials. Top therapeutic interventions include diclofenac, ketoprofen, and celecoxib. A subtype of injury — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 268
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | ankle injury |
| Mondo ID | MONDO:0043895 |
| MeSH | D016512 |
| SNOMED CT | 125603006 |
| Anatomy (UBERON) | UBERON:0004454 |
| Is cancer (heuristic) | no |
Also known as: ankle injury · ankle sprain · ankle Sprains · Injuries, ankle · Injuries, syndesmotic · injury of ankle · injury of tarsal region · injury, ankle · injury, syndesmotic · sprain, ankle · Sprains, ankle · syndesmotic Injuries · syndesmotic injury · tarsal region injury
Disease family
This is a subtype of injury. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: injury › ankle injury
Related subtypes (9): ischemia reperfusion injury, bone fracture, acute lung injury, spinal injury, radiation injury, burn, nervous system injury, frostbite, head injury
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 268.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 232 |
| PHASE3 | 16 |
| PHASE4 | 9 |
| PHASE2 | 6 |
| PHASE1/PHASE2 | 2 |
| PHASE2/PHASE3 | 1 |
| PHASE1 | 1 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00446797 | PHASE4 | COMPLETED | Open Label Comparative Study On Celecoxib Efficacy And Safety Vs Non-Selective NSAID In Acute Pain Due To Ankle Sprain |
| NCT01037816 | PHASE4 | COMPLETED | FS-67 in the Treatment of Pediatric Patients With Ankle Sprain |
| NCT01666197 | PHASE4 | COMPLETED | Efficacy and Safety of Diclofenac Potassium 25 mg Tablet Taken Three Times Daily in Subjects With Acute Joint Pain |
| NCT01957215 | PHASE4 | COMPLETED | Efficacy of Topical Indomethacin Patch Over Placebo in Ankle Sprain Pain Relief |
| NCT02246361 | PHASE4 | COMPLETED | Impact of Six Patient Information Leaflets (PIL) on Doctor Patient Communication |
| NCT02393846 | PHASE4 | COMPLETED | Topical Ketoprofen Versus Placebo in Patients With Ankle Sprain |
| NCT02491736 | PHASE4 | UNKNOWN | Ketoprofen Gel vs Placebo in Children With Ankle Sprain |
| NCT06086418 | PHASE4 | COMPLETED | Perineural Dexamethasone on the Duration of Popliteal Nerve Block for Anesthesia After Pediatric Ankle Surgery |
| NCT06563271 | PHASE4 | COMPLETED | Approach to Ankle Sprains in the Emergency Department |
| NCT00640705 | PHASE2/PHASE3 | TERMINATED | Diclofenac Patch for Treatment of Mild to Moderate Ankle Sprain |
| NCT00680784 | PHASE3 | COMPLETED | HKT-500 in Adult Patients With Ankle Sprain |
| NCT00869180 | PHASE3 | COMPLETED | Diclofenac Patch for Treatment of Acute Pain Due to Mild to Moderate Ankle Sprain |
| NCT00906672 | PHASE3 | COMPLETED | Medico Economic Evaluation of Dermal Substitute Integra® for Coverage of Inferior Limb Traumatic Skin Loss |
| NCT00927641 | PHASE3 | COMPLETED | HKT-500 in the Treatment of Adult Patients With Ankle Sprain |
| NCT01198834 | PHASE3 | COMPLETED | MRX-7EAT Etodolac-Lidocaine Topical Patch in the Treatment of Ankle Sprains |
| NCT01255423 | PHASE3 | COMPLETED | Efficacy and Safety of Diclofenac Sodium Topical Gel 1% Applied 4 Times Daily in Subjects With Acute Ankle Sprain |
| NCT01259752 | PHASE3 | COMPLETED | Compression Stockings in Ankle Sprain |
| NCT01272934 | PHASE3 | COMPLETED | Efficacy and Safety of Diclofenac Sodium Topical Gel 1% Applied Four Times Daily in Subjects With Acute Ankle Sprain |
| NCT01824095 | PHASE3 | TERMINATED | Chiropractic Care and a Specific Regimen of Nutritional Supplementation for Patients With Acute Ankle Sprain |
| NCT01874626 | PHASE3 | COMPLETED | Efficacy and Safety of SST 0225, a Topical Ibuprofen Cream, in the Treatment of Pain Associated With Acute Ankle Sprain |
| NCT01945034 | PHASE3 | COMPLETED | 5% Topical Ibuprofen (IBU) for Ankle Sprain |
| NCT02324270 | PHASE3 | COMPLETED | Safety and Efficacy of Generic Diclofenac Epolamine Acute Pain Due to Minor Ankle Sprain |
| NCT03507803 | PHASE3 | UNKNOWN | Effects of Gait Biofeedback and Impairment-based Rehabilitation in Individuals With Chronic Ankle Instability |
| NCT06192420 | PHASE3 | COMPLETED | TRAUMED - a Clinical Trial in Acute Ankle Sprain |
| NCT06866613 | PHASE3 | COMPLETED | Phase III Trial to Evaluate the Efficacy and Safety in Patients With Ankle Sprains. |
| NCT07475663 | PHASE3 | COMPLETED | Counterpain PXM Versus Diclofenac Versus Piroxicam |
| NCT00573768 | PHASE2 | COMPLETED | Efficacy and Safety of Diclofenac Diethylamine 2.32% Gel in Patients With Acute Ankle Sprain |
| NCT00847769 | PHASE1/PHASE2 | COMPLETED | Ankle Sprains and Corticospinal Excitability |
| NCT00884988 | PHASE2 | SUSPENDED | Lymphomyosot for Ankle Edema Following Fracture |
| NCT01586390 | PHASE2 | COMPLETED | Functional Treatment for Acute Ankle Sprains: Softcast Wrap Versus MOKcast |
| NCT02091674 | PHASE2 | COMPLETED | Management of Acute Ankle Sprain With Sodium Hyaluronate |
| NCT02729207 | PHASE2 | TERMINATED | Proof-of-concept Study of NSAID Hydrogel Patch in Treatment of Acute Pain |
| NCT02810002 | PHASE1/PHASE2 | COMPLETED | Assessing Foot Injuries in Infantry Recruits Wearing Different Boots |
| NCT02892500 | PHASE2 | TERMINATED | Investigation of Corticosteroid Versus Placebo Injection in Patients With Syndesmotic Ligament Injury or High Ankle Sprain |
| NCT00432705 | PHASE1 | COMPLETED | Changes in Unstable Ankles After Balance Training |
| NCT04302961 | EARLY_PHASE1 | COMPLETED | Effects of Gait Retraining With Auditory Feedback |
| NCT03643926 | Not specified | RECRUITING | Arthroscopic Versus Open Brostrom for Ankle Instability |
| NCT03663361 | Not specified | RECRUITING | Addressing Neuromuscular Deficits for Improved Outcomes in Ankle Rehabilitation |
| NCT04095598 | Not specified | RECRUITING | Computed Tomography with Stress Maneuvers for Evaluation of Distal Tibiofibular Syndesmosis Instability (CTMETS) |
| NCT04493645 | Not specified | ACTIVE_NOT_RECRUITING | Ankle Instability Using Foot Intensive Rehabilitation |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| DICLOFENAC | 4 | 8 |
| KETOPROFEN | 4 | 2 |
| CELECOXIB | 4 | 1 |
| ETODOLAC | 4 | 1 |
| HYALURONIC ACID | 4 | 1 |
| INDOMETHACIN | 4 | 1 |
| PIROXICAM | 4 | 1 |
| POWDERED CELLULOSE | 3 | 1 |
| ISOXAFLUTOLE | 2 | 2 |