Ankyloglossia

Summary

Ankyloglossia (MONDO:0007125) is a disease and 20 clinical trials. Top therapeutic interventions include alfentanil, rocuronium, and lavender oil. A subtype of tongue disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 20

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	ankyloglossia
Mondo ID	MONDO:0007125
MeSH	C562396, D000072676
OMIM	106280
DOID	DOID:0060604
ICD-10-CM	Q38.1
ICD-11	1838543063
NCIT	C124538
SNOMED CT	67787004
UMLS	C4759698
MedGen	1673143
Is cancer (heuristic)	no

Also known as: ankyloglossia · FUSED to floor of mouth

Disease family

This is a subtype of tongue disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › mouth disorder › tongue disorder › ankyloglossia

Related subtypes (8): hypertrophy of tongue papillae, glossitis, hairy tongue, fissured tongue, isolated congenital hypoglossia/aglossia, digestive duplication cyst of the tongue, tongue neoplasm, glossodynia

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 20.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	20

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06830148	Not specified	RECRUITING	Post-Procedural Manual Manipulation for Infant Ankyloglossia
NCT07110948	Not specified	ENROLLING_BY_INVITATION	Long-term Follow-up of Infant Frenotomy/Frenectomy Through Early Childhood
NCT07512765	Not specified	ACTIVE_NOT_RECRUITING	Ankyloglossia and Its Effects on Breastfeeding, Feeding and Speech Disorders. A Prospective Study From Birth to 4 Years of Age.
NCT07557875	Not specified	RECRUITING	Healing Efficacy of Diode Laser in Lingual Frenectomy
NCT00967915	Not specified	COMPLETED	Efficacy of Neonatal Release of Ankyloglossia
NCT01550354	Not specified	COMPLETED	Comparison Among Propofol, Alfentanil and Rocuronium as Adjunct to Sevoflurane Anesthesia for Endotracheal Intubation in Children With Frenectomy
NCT02141243	Not specified	COMPLETED	Prospective Evaluation of Lingual Frenotomy in Newborns With Simultaneous Lip Tie for the Relief of Breastfeeding Pain.
NCT02642133	Not specified	COMPLETED	Breastfeeding Improvement Following Tongue-tie and Lip-tie Release
NCT02936518	Not specified	COMPLETED	Anterior Lingual Frenectomy is Inadequate in Improving Breastfeeding Outcomes: a Prospective Cohort Study
NCT03793413	Not specified	COMPLETED	The Impact of Lingual Frenotomy on Bottle Feeding Mechanics
NCT04056936	Not specified	UNKNOWN	The Scope of Tongue-tie in Norway: Its Prevalence and Consequences for Child Health
NCT04703946	Not specified	COMPLETED	Incidence of Short Sublingual Frenulum in Newborns at the Hospital Nostra Senyora de Meritxell.
NCT04867824	Not specified	UNKNOWN	The Use of Lavender vs Vanilla Essential Oil as Complementary Analgesia for Frenotomy in Healthy Newborns
NCT04877392	Not specified	COMPLETED	Analgesic Effect of Inhaled Lavender Essential Oil for Clipping of Tongue-ties
NCT05135481	Not specified	WITHDRAWN	Dedicated Lactation Support in Infants With Tongue - Tie; a Randomised Control Trial
NCT05843279	Not specified	COMPLETED	Physiotherapy in the Treatment of Breastfeeding Difficulties
NCT05878262	Not specified	COMPLETED	The Effect of Pre-emptive Analgesia on the Postoperative Pain in Children Undergoing Pediatric Stomatology Day Surgeries
NCT06089629	Not specified	UNKNOWN	Frenuloplasty for Speech and Myofunctional Outcomes
NCT06856564	Not specified	COMPLETED	Tongue Mobility in Patients with Ankyloglossia Following Frenectomy
NCT06869902	Not specified	COMPLETED	Use of Inhaled Colostrum to Control Pain in Neonatal Frenotomy and Comparison to Inhaled Lavender Essential Oil

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
ALFENTANIL	4	1
ROCURONIUM	4	1
LAVENDER OIL	3	1
CHEMBL4067090	0	1