Annular pancreas

Summary

Annular pancreas (MONDO:0008183) is a disease. A subtype of pancreas disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: 1-9 / 100 000 (Worldwide) [Orphanet-validated]
• Phenotypes (HPO): 3

Clinical features

Epidemiology

Prevalence records

16 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Point prevalence	1-9 / 100 000	4.5	Worldwide	Validated
Prevalence at birth	1-9 / 100 000	1.8	Europe	Validated
Prevalence at birth	1-5 / 10 000	29.4	Austria	Validated
Prevalence at birth	1-9 / 100 000	2.9	Belgium	Validated
Prevalence at birth	1-5 / 10 000	21.3	Denmark	Validated
Prevalence at birth	1-9 / 100 000	7.9	France	Validated
Prevalence at birth	1-9 / 100 000	5.9	Germany	Validated
Prevalence at birth	1-9 / 100 000	1	Hungary	Validated
Prevalence at birth	1-9 / 100 000	3.6	Ireland	Validated
Prevalence at birth	1-9 / 100 000	5.7	Italy	Validated
Prevalence at birth	1-5 / 10 000	24.9	Malta	Validated
Prevalence at birth	1-5 / 10 000	17.1	Netherlands	Validated
Prevalence at birth	1-9 / 1 000 000	0.7	Poland	Validated
Prevalence at birth	1-9 / 100 000	3.1	Spain	Validated
Prevalence at birth	1-9 / 1 000 000	0.8	United Kingdom	Validated
Prevalence at birth	1-9 / 100 000	3.2	Ukraine	Validated

Signs & symptoms

Clinical features (HPO)

3 HPO clinical features (Orphanet curated; top 3 by frequency):

HPO ID	Term	Frequency
HP:0001734	Annular pancreas	Very frequent (80-99%)
HP:0100867	Duodenal stenosis	Very frequent (80-99%)
HP:0005250	High intestinal obstruction	Frequent (30-79%)

Identifiers

Disease identifiers

Field	Value
Canonical name	annular pancreas
Mondo ID	MONDO:0008183
MeSH	C536376
OMIM	167750
Orphanet	675
DOID	DOID:0060850
ICD-10-CM	Q45.1
ICD-11	1311285827
NCIT	C98813
SNOMED CT	40315008
UMLS	C0149955
MedGen	56211
GARD	0000705
MedDRA	10071757
Is cancer (heuristic)	no

Disease family

This is a subtype of pancreas disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › digestive system disorder › pancreas disorder › annular pancreas

Related subtypes (13): pancreatic steatorrhea, pancreatic mucinous ductal ectasia, exocrine pancreatic insufficiency, endocrine pancreas disorder, pancreatitis, pancreatic triacylglycerol lipase deficiency, follicular cholangitis and pancreatitis, congenital pancreatic cyst, recurrent acute pancreatitis, accessory pancreas, pancreatic neoplasm, acinar cystic transformation of the pancreas, lymphoepithelial cyst of the pancreas

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.