Anovulation

Summary

Anovulation (MONDO:0002775) is a disease and 45 clinical trials. Top therapeutic interventions include clomiphene, follitropin alfa, and citric acid. A subtype of ovarian disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 45

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	anovulation
Mondo ID	MONDO:0002775
MeSH	D000858
DOID	DOID:3781
ICD-11	563648258
UMLS	C0003128
MedGen	1951
Is cancer (heuristic)	no

Disease family

This is a subtype of ovarian disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › reproductive system disorder › gonadal disorder › ovarian disorder › anovulation

Related subtypes (10): ovarian dysfunction, ovarian cyst, ovarian stromal hyperthecosis, luteoma of pregnancy, ovarian endometriosis, oophoritis, ovarian hyperstimulation syndrome, ovarian neoplasm, ovarian remnant syndrome, ovarian ectopic pregnancy

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

3 approved, 2 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Choriogonadotropin Alfa	Approved (phase 4)
Follitropin Alfa	Approved (phase 4)
Follitropin Delta	Approved (phase 4)
Follitropin	Phase 3 (in late-stage trials)
Urofollitropin	Phase 3 (in late-stage trials)

Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Anastrozole, Gonadotropin, Chorionic, Letrozole.

Clinical trials & evidence

Clinical trials

Clinical trials: 45.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	26
PHASE4	9
PHASE3	6
PHASE2	3
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00471523	PHASE4	COMPLETED	Treatment of Anovulatory Infertility in PCOS Patients
NCT00473538	PHASE4	COMPLETED	Structured Exercise Training Program Versus Hypocaloric Hyperproteic Diet in Obese Anovulatory Infertile Patients With PCOS
NCT00558077	PHASE4	COMPLETED	Second-Line Treatments for Anovulatory Infertility in PCOS Patients
NCT00953355	PHASE4	COMPLETED	Metformin and Folate Supplementation in Polycystic Ovary Syndrome (PCOS) Patients
NCT01004068	PHASE4	COMPLETED	Short-term Structured Exercise Training Program Plus Diet Intervention in Patients With Polycystic Ovary Syndrome (PCOS)
NCT01250821	PHASE4	COMPLETED	Gonadotrophin Dosage Using a Threshold Nomogram for Ovulation Induction in WHO Group II Anovulatory Infertility
NCT02186782	PHASE4	UNKNOWN	Concomitant CC and E2 Versus CC Alone in Ovulation Induction
NCT02703649	PHASE4	COMPLETED	Administration of Single High Dose Letrozole for Ovulation Induction
NCT03252223	PHASE4	COMPLETED	Ovarian Response to Recombinant Follicle Stimulating Hormone in Women With PCOS
NCT00413179	PHASE3	COMPLETED	The Effect of Metformin Added to Clomiphene Citrate on Pregnancy Rates in Hyperandrogenic, Chronic Oligoovulatory or Anovulatory Women
NCT01008319	PHASE3	COMPLETED	Traditional Clomiphene Citrate Administration vs. Stair-step Approach
NCT01653743	PHASE3	COMPLETED	Trial to Assess the Clinical Efficacy and Safety of MSJ-0011 in Inducing Ovulation in Anovulatory or Oligo-ovulatory Japanese Women
NCT01820728	PHASE3	COMPLETED	A Phase III Clinical Study to Compare the Efficacy and Safety of DA-3801 and That of Gonal-F®
NCT01923194	PHASE3	COMPLETED	Evaluation of Efficacy and Safety of Highly Purified Urofollitropin for Ovulation Induction in Chinese Females
NCT02335879	PHASE3	COMPLETED	Phase III Clinical Study of Domestic Recombinant Human Follitropin for Injection to Treat WHO Class II Anovulation
NCT00213148	PHASE2	COMPLETED	Comparison of Anastrozole Verses Clomiphene Citrate in Stimulating Follicular Growth and Ovulation in Infertile Women With Ovulatory Dysfunction
NCT02551367	PHASE2	UNKNOWN	Letrozole Versus Clomiphene Citrate for Ovulation Induction in Women With Poly Cystic Ovary Syndrome ( PCOS )
NCT03864068	PHASE2	COMPLETED	Inositol Supplementation to Treat PCOS (INSUPP-PCOS)
NCT01289756	PHASE1	COMPLETED	Influence of Pharmacogenetic Factors, Paroxetine and Clarithromycin on Pharmacokinetics of Clomiphene
NCT04650880	Not specified	RECRUITING	Effect of Vitamin D on Ovulation Rate in Women With Polycystic Ovary Syndrome
NCT07159880	Not specified	RECRUITING	Letrozole Extended vs Traditional Therapy for Ovulation Induction in Women With PCOS (PROLEx-PCOS)
NCT00011388	Not specified	COMPLETED	Reproductive Effects of Pesticide, PCB and Mercury Exposure in Laotian Immigrants
NCT00239603	Not specified	COMPLETED	Efficacy Study of the OV-Watch™ Personal Fertility Monitor for Women Using Clomiphene Citrate.
NCT00260286	Not specified	COMPLETED	Effects of Gynecological Age on LH Sensitivity to Energy Availability
NCT00292773	Not specified	COMPLETED	Weight Reduction Surgery and Ovarian Function
NCT00292799	Not specified	COMPLETED	An RCT of Metformin Vs Orlistat in Obese Anovulatory Women
NCT00327366	Not specified	COMPLETED	Effect of Bright Light on Sex Hormones and Ovulation in Humans
NCT00453219	Not specified	WITHDRAWN	FHA: Characterization of Metabolic Status, Brain Circuitry, and Stress-Reactivity
NCT00492882	Not specified	COMPLETED	Study of Mechanisms of Anovulation in Polycystic Ovary Syndrome
NCT00643708	Not specified	COMPLETED	Ovarian Laser Treatment in Women With Polycystic Ovarian Syndrome: A Randomized Study on the Laser Dose
NCT00665171	Not specified	UNKNOWN	Whole Genome Analysis for the Detection of Key Genes in the Polycystic Ovary Syndrome
NCT00920634	Not specified	COMPLETED	Protocol for Drug Use Investigation of Follistim Injection (Study P06132)(COMPLETED)
NCT01785719	Not specified	COMPLETED	Evaluation of Ovarian Morphology and Function in Overweight Women During Weight Loss
NCT02269306	Not specified	COMPLETED	Predictors of Ovarian Response During Clomiphene Citrate Ovulation Induction in Patients With Polycystic Ovary Syndrome
NCT02309047	Not specified	UNKNOWN	The Cycle Disturbances, OLigomenorrhea and Amenorrhea (COLA) Study & Biobank
NCT02710981	Not specified	COMPLETED	Sildenafil Vaginal Gel Co-treatment With Clomiphene Citrate in Infertile Women With Thin Endometrium
NCT03018314	Not specified	COMPLETED	Serum Kisspeptin Levels in Infertile Women
NCT03088046	Not specified	COMPLETED	Circulating Androgen Levels Are Not Affected by the Administration of Vaginal Micronized Progesterone for Withdrawal Bleeding in Patients With Polycystic Ovarian Syndrome
NCT03155828	Not specified	WITHDRAWN	Using CPAP to Improve Menstruation in Women With Polycystic Ovarian Syndrome and Obstructive Sleep Apnea
NCT03545945	Not specified	WITHDRAWN	Hysteroscopy in Chronic Anovulation

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
CLOMIPHENE	4	16
FOLLITROPIN ALFA	4	2
CITRIC ACID	4	1
ESTRADIOL	4	1
FOLLITROPIN BETA	4	1
LETROZOLE	4	1
MENOTROPINS	4	1
METFORMIN	4	1
ENCLOMIPHENE	3	10
INOSITOL	3	1