Aphthous stomatitis
diseaseOn this page
Also known as oral aphthae
Summary
Aphthous stomatitis (MONDO:0004845) is a disease and 33 clinical trials. Top therapeutic interventions include apremilast, diphenhydramine, and zinc oxide. A subtype of stomatitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 33
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | aphthous stomatitis |
| Mondo ID | MONDO:0004845 |
| DOID | DOID:9663 |
| ICD-10-CM | K12.0 |
| UMLS | C0038363 |
| MedGen | 20959 |
| Is cancer (heuristic) | no |
Also known as: oral aphthae
Disease family
This is a subtype of stomatitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by developmental or physiological process › inflammatory disease › mucositis › stomatitis › aphthous stomatitis
Related subtypes (6): gingivitis, ulcerative stomatitis, canker sore, chemotherapy-induced oral mucositis, herpes simplex virus gingivostomatitis, denture stomatitis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 33.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 14 |
| PHASE2 | 10 |
| PHASE4 | 3 |
| PHASE3 | 3 |
| PHASE1/PHASE2 | 1 |
| PHASE1 | 1 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT03690544 | PHASE4 | COMPLETED | Apremilast for RAS |
| NCT06923605 | PHASE4 | COMPLETED | The Efficacy of Erythropoietin Oral Gel Versus Erythropoietin Mouthwash in the Management of Recurrent Aphthous Stomatitis |
| NCT07565181 | PHASE4 | COMPLETED | Effect of Zinc Oxide Ointment on Recurrent Aphthous Stomatitis |
| NCT00527306 | PHASE3 | COMPLETED | Prevention of Recurrent Aphthous Stomatitis Using Vitamins |
| NCT04265001 | PHASE3 | COMPLETED | Topical Hyaluronic Acid and Recurrent Aphthous Stomatitis. |
| NCT05542173 | PHASE3 | UNKNOWN | Efficacy and Safety of BALI Association in the Treatment of Aphthous Ulcerations |
| NCT06622213 | PHASE2 | NOT_YET_RECRUITING | Mucoadhesive Film With/without Acmella Oleracea & Triamcinolone Acetonide for Aphthous Ulcers |
| NCT06993337 | PHASE2 | NOT_YET_RECRUITING | Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Recurrent Aphthous Stomatitis |
| NCT00723268 | PHASE2 | UNKNOWN | Evaluation of Therapeutic Effect of 0.5 mg Colchicine and 5 mg Prednisolone on Oral Aphthae |
| NCT01210014 | PHASE2 | COMPLETED | Systemic Zinc Sulphate in Treatment of Recurrent Aphthous Ulcerations:A Doubleblind, Placebo Controled Study |
| NCT01293968 | PHASE2 | COMPLETED | Therapeutic Effects of Ibuprofen, Diphenhydramine and Aluminium MgS on Recurrent Aphthous Stomatitis |
| NCT01652625 | PHASE2 | COMPLETED | Efficacy and Safety Study of Yunnan Baiyao on Minor Recurrent Aphthous Stomatitis |
| NCT02535962 | PHASE2 | WITHDRAWN | Probiotics and Corticosteroids for Treating Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA) |
| NCT02789605 | PHASE2 | COMPLETED | Effectiveness and Safety of Lactobacillus Rhamnosus Lcr35® in the Treatment of Recurrent Aphthous Stomatitis |
| NCT02920658 | PHASE2 | COMPLETED | Topical Non-Aromatic Very Rich in Steranes (NAVS) Naphthalan for the Treatment of Oral Mucosal Diseases |
| NCT03469232 | PHASE1/PHASE2 | UNKNOWN | Effectiveness and Clinical Mechanism of Huanglian-Jiedu Decoction in Patients With Intense-exuberant Stomach Fire Syndrome |
| NCT06039774 | PHASE2 | UNKNOWN | α-Mangostin Hydrogel Film With Chitosan Alginate Base for Recurrent Aphthous Stomatitis (RAS) |
| NCT01122147 | PHASE1 | COMPLETED | Clinical Evaluation of Fluid Extract of Chamomilla Tincture for Oral Aphthae |
| NCT06960278 | EARLY_PHASE1 | COMPLETED | Effect of Alum Stone Containing Mucosal Adhesive Patches on Healing of Recurrent Aphthous Stomatitis |
| NCT06421038 | Not specified | NOT_YET_RECRUITING | Efficacy of Thyme Honey in The Management of Oral Aphthous Ulcers |
| NCT07141758 | Not specified | RECRUITING | Salivary E-cadherin, Calprotectin, and Matrix Metalloproteinase-9 Levels in Recurrent Aphthous Stomatitis |
| NCT00001601 | Not specified | COMPLETED | Evaluation and Treatment of Oral Soft Tissue Diseases |
| NCT00288769 | Not specified | COMPLETED | Oral Vitamin B12 as Potential Treatment of Recurrent Aphthous Stomatitis |
| NCT00315679 | Not specified | COMPLETED | A Trial of Pentoxifylline for the Treatment of Recurrent Aphthous Stomatitis |
| NCT01127724 | Not specified | TERMINATED | Influence of Different Doses of the Vitamin B12 on Recurrent Aphthous Stomatitis |
| NCT01501409 | Not specified | COMPLETED | Effect of Sodium Lauryl Sulfate on Recurrent Aphthous Stomatitis |
| NCT02890524 | Not specified | COMPLETED | Tokushima Night Guard for Recurrent Aphthous Stomatitis |
| NCT04385979 | Not specified | COMPLETED | Curcumin and Nanocurcumin in Oral Aphthous Ulcer |
| NCT04677062 | Not specified | COMPLETED | Safety, Galenic Acceptability and Efficacy of GV-328 Lozenges in Children With Oral Aphthosis |
| NCT04884464 | Not specified | COMPLETED | Hyaluronic Acid in Counteracting Aphthous Stomatitis |
| NCT05772338 | Not specified | UNKNOWN | Efficacy and Safety of BNP105 in the Treatment of Recurrent Aphthous Stomatitis |
| NCT07121361 | Not specified | COMPLETED | Effectiveness of Recurrent Aphthous Stomatitis Mouthwash System for the Treatment of Oral Ulcers |
| NCT07229469 | Not specified | COMPLETED | A Study on Sumac Mouth Rinse for Treating Recurrent Aphthous Stomatitis |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| APREMILAST | 4 | 1 |
| DIPHENHYDRAMINE | 4 | 1 |
| ZINC OXIDE | 4 | 1 |
| ZINC SULFATE | 4 | 1 |
| HONEY | 3 | 1 |
| LACTOBACILLUS ACIDOPHILUS | 3 | 1 |
| SODIUM LAURYL SULFATE | 3 | 1 |
| CHEMBL475165 | 0 | 1 |
| CHEMBL1204779 | 0 | 1 |
| CHEMBL1628 | 0 | 1 |