Appendiceal neoplasm
disease diseaseOn this page
Also known as appendix neoplasmappendix tumorappendix tumourneoplasm of appendixneoplasm of the appendixneoplasm of vermiform appendixtumor of appendixtumor of the appendixtumor of vermiform appendixtumour of appendixtumour of the appendixtumour of vermiform appendixvermiform appendix neoplasmvermiform appendix neoplasm (disease)vermiform appendix tumorvermiform appendix tumour
Summary
Appendiceal neoplasm (MONDO:0001236) is a cancer and 13 clinical trials. Top therapeutic interventions include irinotecan. A subtype of cecal neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Clinical trials: 13
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | appendiceal neoplasm |
| Mondo ID | MONDO:0001236 |
| EFO | EFO:0003880 |
| MeSH | D001063 |
| DOID | DOID:11240 |
| NCIT | C4434 |
| SNOMED CT | 126846004 |
| UMLS | C0003614 |
| MedGen | 1629 |
| GARD | 0027340 |
| Anatomy (UBERON) | UBERON:0001154 |
| Is cancer (heuristic) | yes |
Also known as: appendix neoplasm · appendix tumor · appendix tumour · neoplasm of appendix · neoplasm of the appendix · neoplasm of vermiform appendix · tumor of appendix · tumor of the appendix · tumor of vermiform appendix · tumour of appendix · tumour of the appendix · tumour of vermiform appendix · vermiform appendix neoplasm · vermiform appendix neoplasm (disease) · vermiform appendix tumor · vermiform appendix tumour
Disease family
An umbrella term covering 4 Mondo subtypes.
Classification path: disease › human disease › disease by body system or component › digestive system disorder › intestinal disorder › large intestine disorder › colonic disorder › cecal disorder › cecal neoplasm › appendiceal neoplasm
Related subtypes (4): cecum villous adenoma, cecum cancer, cecum neuroendocrine tumor G1, benign neoplasm of cecum
Subtypes (4): appendix cancer, epithelial tumor of the appendix, benign neoplasm of appendix, appendix neuroendocrine neoplasm
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated or in trials for this disease
No drug has an approved disease-direct ChEMBL indication for this disease.
3 drugs in clinical trials for this disease (phase 2–3, investigational): efficacy not established — a trial record, not an indication.
| Drug | Highest phase |
|---|---|
| Mitomycin | Phase 2 |
| Nintedanib | Phase 2 |
| Thalidomide | Phase 2 |
Clinical trials & evidence
Clinical trials
Clinical trials: 13.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 8 |
| PHASE2 | 5 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT02387203 | PHASE2 | ACTIVE_NOT_RECRUITING | Antibiotic Treatment and Long-term Outcomes of Patients With Pseudomyxoma Peritonei of Appendiceal Origin |
| NCT05913674 | PHASE2 | RECRUITING | Technical Feasibility of Modified Early Post-Operative Intraperitoneal Chemotherapy (mEPIC) |
| NCT00180960 | PHASE2 | TERMINATED | Treatment of a Cancerous Disease of the Peritoneum With Complete Cytoreductive Surgery and Intraperitoneal Chemohyperthermia |
| NCT03246321 | PHASE2 | COMPLETED | PIPAC for Peritoneal Metastases of Colorectal Cancer |
| NCT05185947 | PHASE2 | COMPLETED | Intravenous and Intraperitoneal Paclitaxel and Oral Nilotinib for Peritoneal Carcinomatosis |
| NCT04634448 | Not specified | NOT_YET_RECRUITING | The Prevalence of Appendiceal Tumours in Periappendicular Abscess |
| NCT05623787 | Not specified | ACTIVE_NOT_RECRUITING | Diagnostic Value of Diffusion-weighted Magnetic Resonance in High-risk Colorectal and Appendiceal Neoplasms |
| NCT05734430 | Not specified | RECRUITING | Genetics of Appendix Cancer Study |
| NCT02374411 | Not specified | COMPLETED | Knowledge, Attitudes, and Practice of Surgeons Toward Nutrition Support in HIPEC Patients |
| NCT02599116 | Not specified | UNKNOWN | Gastrointestinal Microbiome Study of Appendiceal Cancer |
| NCT03510923 | Not specified | COMPLETED | Selective Rather Than Routine Histopathological Examination Following Appendectomy and Cholecystectomy |
| NCT05202600 | Not specified | UNKNOWN | Justification of Incidental Appendectomy With Respect to Pathohistological Findings |
| NCT05513183 | Not specified | COMPLETED | Severe Neutropenia After HIPEC Using Mitomycin-C |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| IRINOTECAN | 4 | 1 |
| CHEMBL454299 | 0 | 1 |
Related Atlas pages
- Drugs: Irinotecan