Arcus senilis

Summary

Arcus senilis (MONDO:0007150) is a disease and 1 clinical trial. A subtype of corneal degeneration — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 1

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	arcus senilis
Mondo ID	MONDO:0007150
EFO	EFO:1000818
MeSH	D001112
OMIM	107800
DOID	DOID:11342
ICD-10-CM	H18.41
ICD-11	2142011301
SNOMED CT	231924000
UMLS	C0003742
MedGen	8179
MedDRA	10003082
Is cancer (heuristic)	no

Also known as: arcus of cornea · arcus senilis · corneal arcus

Disease family

This is a subtype of corneal degeneration. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › disorder of orbital region › eye disorder › corneal disorder › corneal degeneration › arcus senilis

Related subtypes (4): phthisical cornea, peripheral degeneration of cornea, nodular degeneration of cornea, band keratopathy

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 1.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT03198897	Not specified	WITHDRAWN	Biomarker for Homozygous Familial Hypercholesterolemia (BioHoFH)