Arterial occlusion

Summary

Arterial occlusion (MONDO:0020673) is a disease and 12 clinical trials. Top therapeutic interventions include minocycline. A subtype of arterial disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 12

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	arterial occlusion
Mondo ID	MONDO:0020673
NCIT	C35318
UMLS	C0264995
MedGen	78117
Anatomy (UBERON)	UBERON:0001637
Is cancer (heuristic)	no

Also known as: arterial obstruction · arterial occlusion

Disease family

This is a subtype of arterial disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › cardiovascular disorder › vascular disorder › arterial disorder › arterial occlusion

Related subtypes (29): vertebral artery insufficiency, splenic artery aneurysm, basilar artery insufficiency, arteriosclerosis disorder, subclavian artery aneurysm, pulmonary artery choriocarcinoma, pulmonary artery leiomyosarcoma, coronary artery disorder, hypertensive disorder, carotid artery disorder, pulmonary embolism, peripheral arterial disease, hypotensive disorder, large artery stroke, aortic disorder, cervical artery dissection, anterior spinal artery syndrome, fibromuscular dysplasia, retinal arterial tortuosity, Sneddon syndrome, celiac trunk compression syndrome, pediatric arterial ischemic stroke, absence of the pulmonary artery, aberrant subclavian artery, anterior spinal artery stroke, arteritis, pulmonary artery disease, fibromuscular dysplasia, multifocal, carotid web

Subtypes (4): cerebral artery occlusion, vertebral artery occlusion, central retinal artery occlusion, basilar artery occlusion

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 12.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	10
PHASE4	1
PHASE2/PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT04196309	PHASE4	COMPLETED	Effect of LOW-molecular-weight Heparin in Reducing Radial Artery Occlusion Rate After Transradial Coronary Catheterization
NCT07594301	PHASE2/PHASE3	RECRUITING	Minocycline After Successful Endovascular Thrombectomy Recanalization in Posterior Circulation Arterial Occlusion (ATTRACTION-MINOP)
NCT06095050	Not specified	RECRUITING	Embolization Treatment of Chronic Refractory Shoulder Tendinopathy
NCT02577796	Not specified	WITHDRAWN	Radial Artery Spasm Leading to Occlusion in Patients Undergoing Coronary Angiogram Via Radial Access
NCT03028025	Not specified	COMPLETED	Comparing TR Band to Statseal in Conjunction With TR Band
NCT03745391	Not specified	COMPLETED	Multimodal Neuroimaging in the Selection of Acute Ischemic Stroke (AIS) Patients to Endovascular Treatment (EVT)
NCT03970538	Not specified	UNKNOWN	PROMISE II: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia
NCT04046952	Not specified	TERMINATED	Comparing TR Band to Statseal in Conjunction With TR Band II
NCT04472091	Not specified	WITHDRAWN	Genicular Artery Embolization (GAE) for Osteoarthritic Knee Pain
NCT05248308	Not specified	WITHDRAWN	Genicular Artery Embolization (GAE) for the Treatment of Chronic Post Knee Arthroplasty Pain
NCT05468957	Not specified	WITHDRAWN	Comparing Perclose to Statseal in Conjunction With Perclose in Femoral 6 French Arteriotomy Closure
NCT05637970	Not specified	COMPLETED	Comparing Perclose to Statseal With Perclose in Transcatheter Aortic Valve Replacement Arteriotomy Closure

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
MINOCYCLINE	4	1